Results 101 to 110 of about 11,225 (206)

DNA Topoisomerases maintain promoters in a state competent for transcriptional activation in Saccharomyces cerevisiae.

PLoS Genetics, 2012
To investigate the role of DNA topoisomerases in transcription, we have studied global gene expression in Saccharomyces cerevisiae cells deficient for topoisomerases I and II and performed single-gene analyses to support our findings.
Jakob Madsen Pedersen, Jacob Fredsoe, Morten Roedgaard, Lotte Andreasen, Kamilla Mundbjerg, Mogens Kruhøffer, Marie Brinch, Mikkel Heide Schierup, Lotte Bjergbaek, Anni Hangaard Andersen   +9 more
doaj   +1 more source

Clinical Features of Seven COL2A1 Variations in Chinese Children With Type II Collagen Disorders

Acta Paediatrica, Volume 114, Issue 7, Page 1720-1730, July 2025.
ABSTRACT Aim Type II collagen, encoded by the collagen type II alpha 1 (COL2A1) gene, is crucial for the structure of cartilage. This study aims to improve our understanding of Spondyloepiphyseal Dysplasia Congenita (SEDC) caused by mutations in COL2A1. We also aim to evaluate the safety and efficacy of growth hormone (GH) therapy in two SEDC patients.
Shumin Zhan, Qin He, Jinna Yuan, Xiaoqin Xu, Ke Huang, Guanping Dong, Junfen Fu, Dingwen Wu, Wei Wu   +8 more
wiley   +1 more source

Histones and histone variant families in prokaryotes

Nature Communications
Histones are important chromatin-organizing proteins in eukaryotes and archaea. They form superhelical structures around which DNA is wrapped. Recent studies have shown that some archaea and bacteria contain alternative histones that exhibit different ...
Samuel Schwab, Yimin Hu, Bert van Erp, Marc K. M. Cajili, Marcus D. Hartmann, Birte Hernandez Alvarez, Vikram Alva, Aimee L. Boyle, Remus T. Dame   +8 more
doaj   +1 more source

Strand separation in negatively supercoiled DNA [PDF]

, 2018
.: We consider Benham's model for strand separation in negatively supercoiled circular DNA, and study denaturation as function of the linking difference density ...
Mazza, Christian
core  

Multiple structures of RNA polymerase II isolated from human nuclei by ChIP-CryoEM analysis

Nature Communications
RNA polymerase II (RNAPII) is a central transcription enzyme that exists as multiple forms with or without accessory factors, and transcribes the genomic DNA packaged in chromatin.
Tomoya Kujirai, Junko Kato, Kyoka Yamamoto, Seiya Hirai, Takeru Fujii, Kazumitsu Maehara, Akihito Harada, Lumi Negishi, Mitsuo Ogasawara, Yuki Yamaguchi, Yasuyuki Ohkawa, Yoshimasa Takizawa, Hitoshi Kurumizaka   +12 more
doaj   +1 more source

Premelting of superhelical DNA: an expression for superhelical energy [PDF]

FEBS Letters, 1981
Vologodskii, A.V., Frank-Kamenetskii, M.D.   +1 more
openaire   +2 more sources

Gene expression and superhelical structure of DNA.

Seibutsu Butsuri, 1984
The intracellular DNA of bacteria, bacteriophage and plasmids is subject to topological constraints that function to maintain it in a superhelical conformation. For the last several years, accumulating evidence has indicated that supercoiling of DNA duplex is required for effective transcription, as well as for the replication and recombination of ...
Ken-ichi YAMAZAKI, Kazuyuki KUROKI, Yasunobu KANO, Fumio IMAMOTO   +3 more
openaire   +2 more sources

Interplay between DNA sequence and negative superhelicity drives R-loop structures. [PDF]

, 2019
R-loops are abundant three-stranded nucleic-acid structures that form in cis during transcription. Experimental evidence suggests that R-loop formation is affected by DNA sequence and topology. However, the exact manner by which these factors interact to
Benham, Craig J, Chedin, Frederic, Hartono, Stella R, Malig, Maika, Stolz, Robert, Sulthana, Shaheen   +5 more
core  

Supercoiled DNA: Structure [PDF]

, 2005
Bowater, RP
core   +1 more source

Chromatin assembly extracts from Drosophila embryos. [PDF]

, 1994
Becker, Peter B., Tsukiyama, Toshio, Wu, Carl   +2 more
core   +1 more source