Results 81 to 90 of about 7,352 (214)

Unpaired bases in superhelical DNA: kinetic evidence [PDF]

Nucleic Acids Research, 1974
Kinetic analysis of the early, fast reaction of superhelical DNA with formaldehyde reveals that this region or regions is 56% "single strand like" in character. Hydrogen-tritium exchange studies coupled with other considerations show that this reaction is not due to a difference in conformational motility between form I and form II molecules, but is ...
R J, Jacob, J, Lebowitz, M P, Printz
openaire   +2 more sources

Binding of Hg(I) and Hg(II) Ions to Amyloid‐Beta (Aβ) Peptide Variants Affect their Structure and Aggregation

ChemBioChem, Volume 26, Issue 24, December 11, 2025.
Mercury (Hg) is a possible risk factor for Alzheimer's disease, where neuronal death is related to amyloid brain plaques containing aggregated amyloid‐β (Aβ) peptides. We show that equimolar Hg(I) or Hg(II) ions inhibit normal Aβ aggregation. Hg(II) binds Aβ(1–40) with an apparent binding affinity 28 ± 8 μM.
Elina Berntsson, Andra Noormägi, Kärt Padari, Jüri Jarvet, Astrid Gräslund, Margus Pooga, Peep Palumaa, Sebastian K. T. S. Wärmländer   +7 more
wiley   +1 more source

A theoretical study of the B-A transition in superhelical DNA

, 1986
Теоретически рассмотрено влияние сверхспирализации ДНК на В–А-переход, индуцированный увеличением концентрации спирта в растворе. Все предсказываемые теорией эффекты радикальным образом зависят от параметра, характеризующего изменение угла спирального ...
Пахомов, Д.В., Вологодский, А.В.   +1 more
core   +1 more source

The Concise Guide to PHARMACOLOGY 2025/26: Ion channels

British Journal of Pharmacology, Volume 182, Issue S1, Page S152-S241, December 2025.
The Concise Guide to Pharmacology 2025/26 marks the seventh edition in this series of biennial publications in the British Journal of Pharmacology. Presented in landscape format, the guide provides a comparative overview of the pharmacology of drug target families. The concise nature of the Concise Guide refers to the style of presentation, being clear,
Stephen P. H. Alexander, Jörg Striessnig, Alasdair J. Gibb, Alistair A. Mathie, Emma L. Veale, Eamonn Kelly, Chloe J. Peach, Jane F. Armstrong, Elena Faccenda, Simon D. Harding, Christopher Southan, Jamie A. Davies, Richard W. Aldrich, Bernard Attali, Austin M. Baggetta, Elvir Becirovic, David J. Beech, Martin Biel, Roslyn M. Bill, Ana I. Caceres, William A. Catterall, Han Chow Chua, Alex C. Conner, Henry Danahay, Paul Davies, Katrien De Clerq, Markus Delling, Francesco Di Virgilio, Simonetta Falzoni, Wei Fang, Stefanie Fenske, Anna Fortuny‐Gomez, Samuel Fountain, George K. Chandy, Mohammad‐Reza Ghovanloo, Steve A. N. Goldstein, Martin Gosling, Christian Grimm, Stephan Grissmer, Kotdaji Ha, Tim G. Hales, Verena Hammelmann, Israel Hanukoglu, Meiqin Hu, Ad P. Ijzerman, Sairam V. Jabba, Mike Jarvis, Anders A. Jensen, Sven E. Jordt, Leonard K. Kaczmarek, Stephan Kellenberger, Charles Kennedy, Brian King, Philip Kitchen, Qiang Liu, Joseph W. Lynch, Rian W. Manville, Jessica Meades, Verena Mehlfeld, Annette Nicke, Stefan Offermanns, Edward Pérez‐Reyes, Leigh D. Plant, Stephan A. Pless, Lachlan D. Rash, Dejian Ren, Hussein N. Rubaiy, Mootaz M. Salman, Werner Sieghart, Lucia G. Sivilotti, Trevor G. Smart, Terrance P. Snutch, Paolo Tammaro, Jinbin Tian, James S. Trimmer, Charlotte Van den Eynde, Paola Vergani, Joris Vriens, Stephen G. Waxman, Aguan D. Wei, Brenda T. Winn, Heike Wulff, Haoxing Xu, Fan Yang, Lixia Yue, Xiaoli Zhang, Michael Zhu   +86 more
wiley   +1 more source

Cytotoxicity of psammaplin A from a two-sponge association may correlate with the inhibition of DNA replication

BMC Cancer, 2004
Background SV40 DNA replication system is a very useful tool to understand the mechanism of replication, which is a tightly regulated process. Many environmental and cellular factors can induce cell cycle arrest or apoptosis by inhibiting DNA replication.
You Song, Yoon Hyun, Park Jang-Su, Kim Dong-Kyoo, Ryu Seung, Ahn Eun-Young, Jiang Yahong, Lee Burm-Jong, Lee Dong, Jung Jee H   +9 more
doaj   +1 more source

Transferability and Reproducibility of the HepaRG CometChip Assay

Environmental and Molecular Mutagenesis, Volume 66, Issue 9, Page 478-491, November 2025.
ABSTRACT This interlaboratory evaluation of HepaRG CometChip was conducted to assess transferability and reproducibility of this new approach methodology (NAM) across four laboratories. Concentrations inducing up to ~70% relative cytotoxicity were determined by the organizing laboratory, and frozen chemical formulation blocks were sent to each ...
Leslie Recio, Carol Swartz, Lincoln Martin, Emily Rottinger, Stefan Pfuhler, Erica Pinkus, Daniel J. Roberts, Leon F. Stankowski, Simran Kaushal, Norah A. Owiti, Bevin P. Engelward   +10 more
wiley   +1 more source

The Structure of the Oligomerization Domain of Lsr2 from Mycobacterium tuberculosis Reveals a Mechanism for Chromosome Organization and Protection

, 2012
Lsr2 is a small DNA-binding protein present in mycobacteria and related actinobacteria that regulates gene expression and influences the organization of bacterial chromatin.
Isabel Usón (319527), Kathrin Meindl, Isabel Usón, Usón Isabel, Arcus Vickery L., David Alland, Radjainia Mazdak, David Alland (31640), Alland, David, Radjainia, Mazdak, Summers, Emma Louise, Vickery L. Arcus (319529), Roberto Colangeli, Alland David, Mazdak Radjainia, Mitra Alok K., Kathrin Meindl (319526), Emma L. Summers (319525), Alok K. Mitra (206395), Roberto Colangeli (31628), Colangeli Roberto, Colangeli, Roberto, Emma L Summers, Meindl, Kathrin, Vickery L Arcus, Summers Emma L., Mazdak Radjainia (319528), Alok K Mitra, Summers, Emma L., Mitra, Alok K., Meindl Kathrin, Arcus, Vickery L., Usón, Isabel   +32 more
core   +1 more source

Extracellular Vesicle‐Mediated Regulation of H3C14 Contributes to Gemcitabine Resistance in Bladder Cancer

Journal of Extracellular Vesicles, Volume 14, Issue 11, November 2025.
H3C14 modulates gemcitabine metabolism and is selectively excluded via extracellular vesicles (EVs) in gemcitabine (GCB)‐resistant bladder cancer. CD9⁺/CD63⁺/CD81⁺ EVs (Transport‐EVs) transmit resistance, whereas CD147⁺/LAMB1⁺ EVs (Excretion‐EVs) excrete tumour‐suppressive cargos, highlighting the functional divergence of EV subtypes in GCB resistance.
Cheng‐Shuo Huang, Dah‐Shyong Yu, Shih Sheng Jiang, Ying‐Si Wu, Jar‐Yi Ho, Cheng‐Ping Yu   +5 more
wiley   +1 more source

Topoisomerase II. Its role in conformation changes in superhelical nuclear DNA of lymphocytes after γ-irradiation

, 1985
Исследовано действие ингибиторов топоизомеразной ферментативной системы (новобиоцина, налидиксовой кислоты) на восстановление нарушенной облучением (8 Гр) суперспиральной структуры ядерной ДНК лимфоцитов крысы.
Комар, В.Е., Щедрина, Л.В., Ващенко, В.И.   +2 more
core   +1 more source

Promoter prediction and annotation of microbial genomes based on DNA sequence and structural responses to superhelical stress

BMC Bioinformatics, 2006
Background In our previous studies, we found that the sites in prokaryotic genomes which are most susceptible to duplex destabilization under the negative superhelical stresses that occur in vivo are statistically highly significantly associated with ...
Benham Craig J, Wang Huiquan
doaj   +1 more source