Results 81 to 90 of about 7,436 (214)
The Plant Genome, Volume 19, Issue 1, March 2026.Abstract Target of rapamycin (TOR) is an evolutionarily conserved serine/threonine kinase that plays a central role in regulating biological growth, development, and stress responses in eukaryotes. However, the TOR signaling pathway has not been thoroughly studied in apple (Malus domestica).
Dehai Liu +7 more
wiley +1 more source
Modulation of intramolecular interactions in superhelical DNA by curved sequences: a Monte Carlo simulation study [PDF]
, 1995 A Monte Carlo model for the generation of superhelical DNA structures at thermodynamic equilibrium (Klenin et al., 1991; Vologodskii et al., 1992) was modified to account for the presence of local curvature.
Klenin, K.V. +2 more
core +1 more source
Molecules, 2013 ADAM-15, with known zymogen, secretase, and disintegrin activities, is a catalytically active member of the ADAM family normally expressed in early embryonic development and aberrantly expressed in various cancers, including breast, prostate and lung ...
Robert V. Brown +3 more
doaj +1 more source
Conformational change-induced repeat domain expansion regulates Rap phosphatase quorum-sensing signal receptors. [PDF]
PLoS Biology, 2013 The large family of Gram-positive quorum-sensing receptors known as the RNPP proteins consists of receptors homologous to the Rap, NprR, PlcR, and PrgX proteins that are regulated by imported oligopeptide autoinducers.
Vijay Parashar +2 more
doaj +1 more source
Coumarin‐Augmented Thiazole Hybrids as Dual Anticancer and Antibacterial Agents
Chemical Biology &Drug Design, Volume 107, Issue 2, February 2026.Compound 13, a coumarin‐thiazole hybrid, is shown engaging the ATP‐binding site of S. aureus GyrB through a novel hydrogen bond with residue SER129. The molecule exhibits dual antibacterial and anticancer activity, supporting its potential as a dual‐target topoisomerase inhibitor.
Islam K. Matar +6 more
wiley +1 more source
Analytical Cellular Pathology, Volume 2026, Issue 1, 2026.Colorectal cancer (CRC) remains a formidable global health challenge, characterized by uncontrolled cell proliferation and significant socioeconomic burden. Projections anticipate a substantial increase in new cases, straining healthcare systems worldwide.
Birhanemaskal Malkamu +1 more
wiley +1 more source
Human Mutation, Volume 2026, Issue 1, 2026.Chromodomain‐helicase‐DNA‐binding protein 4 (CHD4) is a critical ATP‐dependent chromatin remodeler that plays fundamental roles in transcriptional repression, DNA damage repair, and lineage specification, making it indispensable for cardiovascular development and function.
Apolonia Novillo +6 more
wiley +1 more source
Selective binding of specific mouse genomic DNA fragments by mouse vimentin filaments in vitro [PDF]
, 1996 Mouse vimentin intermediate filaments (IFs) reconstituted in vitro were analyzed for their capacity to select certain DNA sequences from a mixture of about 500−bp−long fragments of total mouse genomic DNA.
Shoeman, R. +7 more
core +1 more source
BMC Cancer, 2004 Background SV40 DNA replication system is a very useful tool to understand the mechanism of replication, which is a tightly regulated process. Many environmental and cellular factors can induce cell cycle arrest or apoptosis by inhibiting DNA replication.
You Song +9 more
doaj +1 more source
Journal of Chemistry, Volume 2026, Issue 1, 2026.Four ergostanes—ergosta‐7,22,24(28)‐trien‐3β‐ol (1), ergosta‐7,24(28)‐dien‐3‐one (2), ergosta‐7,22,24(28)‐trien‐3‐one (3), and ergosta‐4,6,8(14),22‐tetraen‐3‐one (4)—and one cytochalasin, zygosporin D (5), were isolated from Xylaria longipes. Two compounds, 2 and 3, are novel but have a similar structure to Compound (1), except for the keto group at ...
Alice W. Njue +5 more
wiley +1 more source