Results 71 to 80 of about 7,436 (214)
Free energy profile for unwrapping outer superhelical turn of CENP-A nucleosome
Biophysics and Physicobiology, 2019 Eukaryotic genome is packaged in a nucleus in the form of chromatin. The fundamental structural unit of the chromatin is the protein-DNA complex, nucleosome, where DNA of about 150 bp is wrapped around a histone core almost twice.
Hidetoshi Kono +2 more
doaj +1 more source
Superhelical destabilization in regulatory regions of stress response genes. [PDF]
PLoS Computational Biology, 2008 Stress-induced DNA duplex destabilization (SIDD) analysis exploits the known structural and energetic properties of DNA to predict sites that are susceptible to strand separation under negative superhelical stress.
Huiquan Wang, Craig J Benham
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Theoretical study of cruciform states in superhelical DNAs [PDF]
FEBS Letters, 1982 The most probable sites for the attack of singlestrand specific endonucleases in some superhelical DNAs are the centers of the longest palindromic sequences [1,2]. These findings accord with the earlier theoretical prediction that the probability of cruciform states for large palindromes should increase with superhelix density 131.
Vologodskii, A.V. +1 more
openaire +2 more sources
Advanced Science, Volume 13, Issue 20, 9 April 2026.Prenatal dexamethasone exposure (PDE) programs persistent podocyte developmental injury and adult glomerulosclerosis. Mechanistically, glucocorticoid receptor (GR) binds the miR‐135a‐5p promoter and recruits the histone acetyltransferase p300, increasing promoter histone acetylation and sustaining miR‐135a‐5p expression. Elevated miR‐135a‐5p suppresses
Xiaoqi Zhao +8 more
wiley +1 more source
A novel Porphyromonas gingivalis enzyme: An atypical dipeptidyl peptidase III with an ARM repeat domain. [PDF]
PLoS ONE, 2017 Porphyromonas gingivalis, an asaccharolytic Gram-negative oral anaerobe, is a major pathogen associated with adult periodontitis, a chronic infective disease that a significant percentage of the human population suffers from.
Altijana Hromić-Jahjefendić +11 more
doaj +1 more source
Unpaired bases in superhelical DNA: kinetic evidence [PDF]
Nucleic Acids Research, 1974 Kinetic analysis of the early, fast reaction of superhelical DNA with formaldehyde reveals that this region or regions is 56% "single strand like" in character. Hydrogen-tritium exchange studies coupled with other considerations show that this reaction is not due to a difference in conformational motility between form I and form II molecules, but is ...
R J, Jacob, J, Lebowitz, M P, Printz
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Accessing New Phenanthroline–Oxazine Scaffolds as Copper‐Dependent DNA Damaging Probes
ChemBioChem, Volume 27, Issue 8, April 2026.New phenanthroline–oxazine ligands derived from natural amino acids are synthesized through an optimized, predictive strategy. When coordinated to copper, these scaffolds display tunable DNA binding, groove selectivity, and oxidative cleavage activity, revealing clear structure activity relationships and expanding the toolbox of copper‐dependent ...
Rebecca Lynn +10 more
wiley +1 more source
Brain‐X, Volume 4, Issue 1, March 2026.Electroacupuncture (EA) reduces H3K18ac enrichment at the Ubp1 promoter in the hippocampus in chronic cerebral hypoperfusion (CCH) rats by upregulating SIRT7‐mediated deacetylation, thereby suppressing the expression of UBP1. This EA‐dependent epigenetic regulation increases dendritic spine density and enhances long‐term potentiation, leading to ...
Wenju Wang +17 more
wiley +1 more source
Variola Type IB DNA Topoisomerase: DNA Binding and Supercoil Unwinding Using Engineered DNA Minicircles [PDF]
, 2015 Type IB topoisomerases unwind positive and negative DNA supercoils and play a key role in removing supercoils that would otherwise accumulate at replication and transcription forks.
Breeana G. Anderson (1325925) +1 more
core +1 more source
Hopping into a hot seat: Role of DNA structural features on IS5-mediated gene activation and inactivation under stress. [PDF]
PLoS ONE, 2017 Insertion sequence elements (IS elements) are proposed to play major roles in shaping the genetic and phenotypic landscapes of prokaryotic cells. Recent evidence has raised the possibility that environmental stress conditions increase IS hopping into new
M Zafri Humayun +4 more
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