Results 71 to 80 of about 11,225 (206)
Supercoiled DNA: Structure [PDF]
, 2015 Supercoiling is introduced into DNA molecules when the double helix is twisted around its own axis in three‐dimensional space. Experimental techniques that are sensitive to molecular shape can be used to analyse the topological states of DNA, but the ...
Bowater, Richard
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Theoretical study of cruciform states in superhelical DNAs [PDF]
FEBS Letters, 1982 The most probable sites for the attack of singlestrand specific endonucleases in some superhelical DNAs are the centers of the longest palindromic sequences [1,2]. These findings accord with the earlier theoretical prediction that the probability of cruciform states for large palindromes should increase with superhelix density 131.
Vologodskii, A.V. +1 more
openaire +2 more sources
Journal of Chemistry, Volume 2026, Issue 1, 2026.Four ergostanes—ergosta‐7,22,24(28)‐trien‐3β‐ol (1), ergosta‐7,24(28)‐dien‐3‐one (2), ergosta‐7,22,24(28)‐trien‐3‐one (3), and ergosta‐4,6,8(14),22‐tetraen‐3‐one (4)—and one cytochalasin, zygosporin D (5), were isolated from Xylaria longipes. Two compounds, 2 and 3, are novel but have a similar structure to Compound (1), except for the keto group at ...
Alice W. Njue +5 more
wiley +1 more source
Hopping into a hot seat: Role of DNA structural features on IS5-mediated gene activation and inactivation under stress. [PDF]
PLoS ONE, 2017 Insertion sequence elements (IS elements) are proposed to play major roles in shaping the genetic and phenotypic landscapes of prokaryotic cells. Recent evidence has raised the possibility that environmental stress conditions increase IS hopping into new
M Zafri Humayun +4 more
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Structural ultrafast dynamics of macromolecules: diffraction of free DNA and effect of hydration [PDF]
, 2009 Of special interest in molecular biology is the study of structural and conformational changes which are free of the additional effects of the environment.
Lin, Milo M. +2 more
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ChemBioChem, Volume 26, Issue 24, December 11, 2025.Mercury (Hg) is a possible risk factor for Alzheimer's disease, where neuronal death is related to amyloid brain plaques containing aggregated amyloid‐β (Aβ) peptides. We show that equimolar Hg(I) or Hg(II) ions inhibit normal Aβ aggregation. Hg(II) binds Aβ(1–40) with an apparent binding affinity 28 ± 8 μM.
Elina Berntsson +7 more
wiley +1 more source
Molecules, 2013 ADAM-15, with known zymogen, secretase, and disintegrin activities, is a catalytically active member of the ADAM family normally expressed in early embryonic development and aberrantly expressed in various cancers, including breast, prostate and lung ...
Robert V. Brown +3 more
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Conformational change-induced repeat domain expansion regulates Rap phosphatase quorum-sensing signal receptors. [PDF]
PLoS Biology, 2013 The large family of Gram-positive quorum-sensing receptors known as the RNPP proteins consists of receptors homologous to the Rap, NprR, PlcR, and PrgX proteins that are regulated by imported oligopeptide autoinducers.
Vijay Parashar +2 more
doaj +1 more source
A cell engineering strategy to enhance supercoiled plasmid DNA production for gene therapy [PDF]
, 2016 With the recent revival of the promise of plasmid DNA vectors in gene therapy, a novel synthetic biology approach was used to enhance the quantity, (yield), and quality of the plasmid DNA.
Hassan, S, Keshavarz-Moore, E, Ward, J
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The B – A transition in superhelical DNA
Nucleic Acids Research, 1990 Relaxation of a DNA superhelical stress due to the B to A transition induced by trifluoroethanol has been studied by assessing the change of DNA orientation in a flow gradient. Using DNAs of different superhelical densities, a decrease in the winding angle during the B----A shift of DNA was found to be 1.5 degrees per base pair in solution.
, Krylov DYu, V L, Makarov, V I, Ivanov
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