Results 71 to 80 of about 7,352 (214)
Free energy profile for unwrapping outer superhelical turn of CENP-A nucleosome
Biophysics and Physicobiology, 2019 Eukaryotic genome is packaged in a nucleus in the form of chromatin. The fundamental structural unit of the chromatin is the protein-DNA complex, nucleosome, where DNA of about 150 bp is wrapped around a histone core almost twice.
Hidetoshi Kono +2 more
doaj +1 more source
Coumarin‐Augmented Thiazole Hybrids as Dual Anticancer and Antibacterial Agents
Chemical Biology &Drug Design, Volume 107, Issue 2, February 2026.Compound 13, a coumarin‐thiazole hybrid, is shown engaging the ATP‐binding site of S. aureus GyrB through a novel hydrogen bond with residue SER129. The molecule exhibits dual antibacterial and anticancer activity, supporting its potential as a dual‐target topoisomerase inhibitor.
Islam K. Matar +6 more
wiley +1 more source
Analytical Cellular Pathology, Volume 2026, Issue 1, 2026.Colorectal cancer (CRC) remains a formidable global health challenge, characterized by uncontrolled cell proliferation and significant socioeconomic burden. Projections anticipate a substantial increase in new cases, straining healthcare systems worldwide.
Birhanemaskal Malkamu +1 more
wiley +1 more source
H-NS forms a superhelical protein scaffold for DNA condensation
, 2010 The histone-like nucleoid structuring (H-NS) protein plays a fundamental role in DNA condensation and is a key regulator of enterobacterial gene expression in response to changes in osmolarity, pH, and temperature.
Stefan T. Arold +3 more
core +1 more source
Hopping into a hot seat: Role of DNA structural features on IS5-mediated gene activation and inactivation under stress. [PDF]
PLoS ONE, 2017 Insertion sequence elements (IS elements) are proposed to play major roles in shaping the genetic and phenotypic landscapes of prokaryotic cells. Recent evidence has raised the possibility that environmental stress conditions increase IS hopping into new
M Zafri Humayun +4 more
doaj +1 more source
Human Mutation, Volume 2026, Issue 1, 2026.Chromodomain‐helicase‐DNA‐binding protein 4 (CHD4) is a critical ATP‐dependent chromatin remodeler that plays fundamental roles in transcriptional repression, DNA damage repair, and lineage specification, making it indispensable for cardiovascular development and function.
Apolonia Novillo +6 more
wiley +1 more source
Molecules, 2013 ADAM-15, with known zymogen, secretase, and disintegrin activities, is a catalytically active member of the ADAM family normally expressed in early embryonic development and aberrantly expressed in various cancers, including breast, prostate and lung ...
Robert V. Brown +3 more
doaj +1 more source
Conformational change-induced repeat domain expansion regulates Rap phosphatase quorum-sensing signal receptors. [PDF]
PLoS Biology, 2013 The large family of Gram-positive quorum-sensing receptors known as the RNPP proteins consists of receptors homologous to the Rap, NprR, PlcR, and PrgX proteins that are regulated by imported oligopeptide autoinducers.
Vijay Parashar +2 more
doaj +1 more source
Journal of Chemistry, Volume 2026, Issue 1, 2026.Four ergostanes—ergosta‐7,22,24(28)‐trien‐3β‐ol (1), ergosta‐7,24(28)‐dien‐3‐one (2), ergosta‐7,22,24(28)‐trien‐3‐one (3), and ergosta‐4,6,8(14),22‐tetraen‐3‐one (4)—and one cytochalasin, zygosporin D (5), were isolated from Xylaria longipes. Two compounds, 2 and 3, are novel but have a similar structure to Compound (1), except for the keto group at ...
Alice W. Njue +5 more
wiley +1 more source
, 2013 (A) The cartoon representation of 11.5 TAL repeats and the DNA. The superhelical pitch of dHax3 is assessed by the distance between the Cα atoms of G303 (Gly303) and G675 (Gly675) (left), and the pitch of DNA by the distance between the C3′ atoms of 1dC ...
Hua Wan (213526) +4 more
core +1 more source