Results 51 to 60 of about 11,225 (206)
An organometallic compound which exhibits a DNA topology-dependent one-stranded intercalation mode [PDF]
, 2016 Understanding how small molecules interact with DNA is essential since it underlies a multitude of pathological conditions and therapeutic interventions.
Adhireksan +16 more
core +3 more sources
Advanced Science, Volume 13, Issue 20, 9 April 2026.Prenatal dexamethasone exposure (PDE) programs persistent podocyte developmental injury and adult glomerulosclerosis. Mechanistically, glucocorticoid receptor (GR) binds the miR‐135a‐5p promoter and recruits the histone acetyltransferase p300, increasing promoter histone acetylation and sustaining miR‐135a‐5p expression. Elevated miR‐135a‐5p suppresses
Xiaoqi Zhao +8 more
wiley +1 more source
Architectural Organization of Dinoflagellate Liquid Crystalline Chromosomes
Microorganisms, 2019 Dinoflagellates have some of the largest genome sizes, but lack architectural nucleosomes. Their liquid crystalline chromosomes (LCCs) are the only non-architectural protein-mediated chromosome packaging systems, having high degrees of DNA superhelicity,
Joseph Tin Yum Wong
doaj +1 more source
A new family of intrinsically disordered proteins: structural characterization of the major phasin PhaF from Pseudomonas putida KT2440. [PDF]
PLoS ONE, 2013 Phasins are intracellular polyhydroxyalkanoat4e (PHA)-associated proteins involved in the stabilization of these bacterial carbon storage granules. Despite its importance in PHA metabolism and regulation, only few reports have focused so far on the ...
Beatriz Maestro +5 more
doaj +1 more source
Accessing New Phenanthroline–Oxazine Scaffolds as Copper‐Dependent DNA Damaging Probes
ChemBioChem, Volume 27, Issue 8, April 2026.New phenanthroline–oxazine ligands derived from natural amino acids are synthesized through an optimized, predictive strategy. When coordinated to copper, these scaffolds display tunable DNA binding, groove selectivity, and oxidative cleavage activity, revealing clear structure activity relationships and expanding the toolbox of copper‐dependent ...
Rebecca Lynn +10 more
wiley +1 more source
Evidence for a Solenoid Phase of Supercoiled DNA
, 2018 In mechanical manipulation experiments, a single DNA molecule overwound at constant force undergoes a discontinuous drop in extension as it buckles and forms a superhelical loop (a plectoneme).
Dittmore, Andrew, Neuman, Keir C.
core +1 more source
Competition between B-Z and B-L transitions in a single DNA molecule: Computational studies [PDF]
, 2016 Under negative torsion, DNA adopts left-handed helical forms, such as Z-DNA and L-DNA. Using the random copolymer model developed for a wormlike chain, we represent a single DNA molecule with structural heterogeneity as a helical chain consisting of ...
Hong, Seok Cheol +5 more
core +1 more source
Brain‐X, Volume 4, Issue 1, March 2026.Electroacupuncture (EA) reduces H3K18ac enrichment at the Ubp1 promoter in the hippocampus in chronic cerebral hypoperfusion (CCH) rats by upregulating SIRT7‐mediated deacetylation, thereby suppressing the expression of UBP1. This EA‐dependent epigenetic regulation increases dendritic spine density and enhances long‐term potentiation, leading to ...
Wenju Wang +17 more
wiley +1 more source
PLoS ONE, 2019 The restricted access of regulatory factors to their binding sites on DNA wrapped around the nucleosomes is generally interpreted in terms of molecular shielding exerted by nucleosomal structure and internucleosomal interactions.
Rosevalentine Bosire +9 more
doaj +1 more source
Superhelical destabilization in regulatory regions of stress response genes. [PDF]
PLoS Computational Biology, 2008 Stress-induced DNA duplex destabilization (SIDD) analysis exploits the known structural and energetic properties of DNA to predict sites that are susceptible to strand separation under negative superhelical stress.
Huiquan Wang, Craig J Benham
doaj +1 more source