Results 51 to 60 of about 7,352 (214)

TALEs from a spring--superelasticity of Tal effector protein structures. [PDF]

open access: yesPLoS ONE, 2014
Transcription activator-like effectors (TALEs) are DNA-related proteins that recognise and bind specific target sequences to manipulate gene expression.
Holger Flechsig
doaj   +1 more source

Specific DNA-RNA Hybrid Recognition by TAL Effectors

open access: yesCell Reports, 2012
The transcription activator-like (TAL) effector targets specific host promoter through its central DNA-binding domain, which comprises multiple tandem repeats (TALE repeats).
Ping Yin   +6 more
doaj   +1 more source

Role of the Discriminator Sequence in the Supercoiling Sensitivity of Bacterial Promoters

open access: yesmSystems, 2021
DNA supercoiling acts as a global transcriptional regulator that contributes to the rapid transcriptional response of bacteria to many environmental changes.
Raphaël Forquet   +4 more
doaj   +1 more source

Stress-induced duplex destabilization (SIDD) profiles for T7 bacteriophage promoters [PDF]

open access: yesКомпьютерные исследования и моделирование, 2018
The functioning of DNA regulatory regions rely primarily on their physicochemical and structural properties but not on nucleotide sequences, i.e. genetic text.
Mikhail Anatolievich Orlov   +4 more
doaj   +1 more source

Pentatricopeptide repeat proteins in crops: Advances in functional mechanisms and breeding applications

open access: yesJournal of Integrative Plant Biology, EarlyView.
Pentatricopeptide repeat proteins coordinate nucleus‐organelle communication by modulating RNA metabolism within chloroplasts and mitochondria. This review highlights how they control critical processes like photosynthesis, seed development, fertility restoration, and stress survival in crops, and explores their potential as programmable tools for RNA ...
Mingming Wu   +7 more
wiley   +1 more source

Light‐Controlled Peptide Self‐Assembly: From Physicochemical Principles to Emerging Biomedical Applications

open access: yesAggregate, Volume 7, Issue 6, June 2026.
This review surveys recent advances in light‐controlled peptide self‐assembly for the design of smart soft matter. It summarizes the underlying physicochemical principles, including thermodynamic control for reshaping free‐energy landscapes, and nonequilibrium control to produce kinetically trapped states and dissipative structures.
Lidong Chen   +7 more
wiley   +1 more source

Architectural Organization of Dinoflagellate Liquid Crystalline Chromosomes

open access: yesMicroorganisms, 2019
Dinoflagellates have some of the largest genome sizes, but lack architectural nucleosomes. Their liquid crystalline chromosomes (LCCs) are the only non-architectural protein-mediated chromosome packaging systems, having high degrees of DNA superhelicity,
Joseph Tin Yum Wong
doaj   +1 more source

A new family of intrinsically disordered proteins: structural characterization of the major phasin PhaF from Pseudomonas putida KT2440. [PDF]

open access: yesPLoS ONE, 2013
Phasins are intracellular polyhydroxyalkanoat4e (PHA)-associated proteins involved in the stabilization of these bacterial carbon storage granules. Despite its importance in PHA metabolism and regulation, only few reports have focused so far on the ...
Beatriz Maestro   +5 more
doaj   +1 more source

miR‐135a‐5p Is a Promising Target to Prevent the Glomerulosclerosis Associated with Podocyte Developmental Toxicity in Offspring Induced by Prenatal Dexamethasone Exposure

open access: yesAdvanced Science, Volume 13, Issue 20, 9 April 2026.
Prenatal dexamethasone exposure (PDE) programs persistent podocyte developmental injury and adult glomerulosclerosis. Mechanistically, glucocorticoid receptor (GR) binds the miR‐135a‐5p promoter and recruits the histone acetyltransferase p300, increasing promoter histone acetylation and sustaining miR‐135a‐5p expression. Elevated miR‐135a‐5p suppresses
Xiaoqi Zhao   +8 more
wiley   +1 more source

X-ray scattering from randomly oriented superhelices. Circular superhelical DNA

open access: yes, 1980
The scattering functions of randomly oriented filaments of finite length exhibiting two orders of helicity have been calculated. It is shown to a good approximation that each order scatters as if present alone as a first order helix of the same contour ...
Brady, G.W., Fein, D.B., Benham, C.J.
core   +1 more source

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