TALEs from a spring--superelasticity of Tal effector protein structures. [PDF]
PLoS ONE, 2014 Transcription activator-like effectors (TALEs) are DNA-related proteins that recognise and bind specific target sequences to manipulate gene expression.
Holger Flechsig
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Single‐Molecule Characterization of Bacterial Factor‐Dependent Transcription Activation by Rob
Advanced Science, EarlyView.Factor‐dependent transcription activation is crucial and involves complex interactions between transcription factors, RNA polymerase, and promoter DNA. Using single‐molecule assays, we show that Rob prebinds RNAP to facilitate promoter search and enhances DNA unwinding and promoter escape.
Yuqiong Zhang +7 more
wiley +1 more source
Topoisomerase II. Its role in conformation changes in superhelical nuclear DNA of lymphocytes after γ-irradiation [PDF]
, 1985 Исследовано действие ингибиторов топоизомеразной ферментативной системы (новобиоцина, налидиксовой кислоты) на восстановление нарушенной облучением (8 Гр) суперспиральной структуры ядерной ДНК лимфоцитов крысы.
Комар, В.Е. +2 more
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Role of the Discriminator Sequence in the Supercoiling Sensitivity of Bacterial Promoters
mSystems, 2021 DNA supercoiling acts as a global transcriptional regulator that contributes to the rapid transcriptional response of bacteria to many environmental changes.
Raphaël Forquet +4 more
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Chromatin Remodelling Complexes in Plant Adaptation to Abiotic Stress: Mechanisms and Perspectives
Plant, Cell &Environment, EarlyView.ABSTRACT As sessile organisms, plants have evolved elaborate epigenetic regulatory networks to adapt to a wide range of abiotic stress. Chromatin remodelling is a core epigenetic regulatory mechanism that refers to the process by which chromatin remodelling complexes mediate dynamic changes in chromatin spatial conformation and DNA accessibility ...
Xiuxiu Zhang, Yueran Zhang, Jiang Li
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Cleavage of circular, superhelical simian virus 40 DNA to a linear duplex by S1 nuclease [PDF]
S(1) nuclease, the single-strand specific nuclease from Aspergillus oryzae can cleave both strands of circular covalently closed, superhelical simian virus 40 (SV40) DNA to generate unit length linear duplex molecules with intact single strands.
Berg, P., Beard, P., Morrow, J. F.
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Architectural Organization of Dinoflagellate Liquid Crystalline Chromosomes
Microorganisms, 2019 Dinoflagellates have some of the largest genome sizes, but lack architectural nucleosomes. Their liquid crystalline chromosomes (LCCs) are the only non-architectural protein-mediated chromosome packaging systems, having high degrees of DNA superhelicity,
Joseph Tin Yum Wong
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Stress-induced duplex destabilization (SIDD) profiles for T7 bacteriophage promoters [PDF]
Компьютерные исследования и моделирование, 2018 The functioning of DNA regulatory regions rely primarily on their physicochemical and structural properties but not on nucleotide sequences, i.e. genetic text.
Mikhail Anatolievich Orlov +4 more
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Molecular Acrobats: How CHD Remodelers Shape the Genetic Playground to License Cell Identity
BioEssays, Volume 48, Issue 7, July 2026.ABSTRACT In eukaryotes, DNA is not a naked repository of genetic information but is tightly wound around histone octamers to form nucleosomes. While this packaging solves the spatial problem of fitting 2 meters of DNA into a microscopic nucleus, it creates a massive accessibility problem for DNA‐templated events, including transcription, replication ...
İsa Özdemir, Sarah J. Hainer
wiley +1 more source
Determination of the number of superhelical turns in simian virus 40 DNA by gel electrophoresis [PDF]
, 1975 Closed-circular, superhelical DNA from simian virus 40 (SV40 DNA I) was treated with an excess of DNA-relaxing enzyme in the presence of increasing amounts of ethidium bromide (EtdBr).
Keller, W.
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