Results 61 to 70 of about 11,225 (206)

Structural diversity of supercoiled DNA [PDF]

, 2015
By regulating access to the genetic code, DNA supercoiling strongly affects DNA metabolism. Despite its importance, however, much about supercoiled DNA (positively supercoiled DNA, in particular) remains unknown.
A Amzallag, A Landy, A Pérez, AA Vetcher, C Bi, CH Laundon, CJ Benham, CJ Benham, D Demurtas, DE Depew, DI Cherny, DJ Price, DN Mastronarde, EF Pettersen, ER Hildebrandt, F Kouzine, F Kouzine, F Lankas, G Tang, GL Randall, HVR Annapureddy, J Bednar, J Dubochet, J Shao, JB Bliska, JD Watson, JF Allemand, JM Fogg, JM Fogg, JP Peters, JR Kremer, JS Mitchell, JW Pavlicek, K Sandman, L Baranello, LM Bond, M Adrian, M Krepl, MW Kilpatrick, PP Lau, PR Kramer, Q Du, S Chong, S Pronk, SA Harris, SD Levene, TA Lionberger, TC Boles, TE Cloutier, TE Cloutier, V Levchenko, V Tsui, VV Rybenkov, W Ross, X Dai, Y Shibata   +55 more
core   +1 more source

SIST: stress-induced structural transitions in superhelical DNA [PDF]

Bioinformatics, 2014
Abstract Summary : Supercoiling imposes stress on a DNA molecule that can drive susceptible sequences into alternative non-B form structures. This phenomenon occurs frequently in vivo and has been implicated in biological processes, such as replication, transcription, recombination and translocation.
Dina, Zhabinskaya, Sally, Madden, Craig J, Benham   +2 more
openaire   +2 more sources

Genome‐wide Identification and expression analysis of TOR signaling pathway components in apple in response to low nitrogen

The Plant Genome, Volume 19, Issue 1, March 2026.
Abstract Target of rapamycin (TOR) is an evolutionarily conserved serine/threonine kinase that plays a central role in regulating biological growth, development, and stress responses in eukaryotes. However, the TOR signaling pathway has not been thoroughly studied in apple (Malus domestica).
Dehai Liu, Siyuan Cheng, Yanghao Long, Qinyao Jin, Yujie Zhou, Fengwang Ma, Xuan Liu, Xiaoqing Gong   +7 more
wiley   +1 more source

Free energy profile for unwrapping outer superhelical turn of CENP-A nucleosome

Biophysics and Physicobiology, 2019
Eukaryotic genome is packaged in a nucleus in the form of chromatin. The fundamental structural unit of the chromatin is the protein-DNA complex, nucleosome, where DNA of about 150 bp is wrapped around a histone core almost twice.
Hidetoshi Kono, Shun Sakuraba, Hisashi Ishida   +2 more
doaj   +1 more source

A novel Porphyromonas gingivalis enzyme: An atypical dipeptidyl peptidase III with an ARM repeat domain. [PDF]

PLoS ONE, 2017
Porphyromonas gingivalis, an asaccharolytic Gram-negative oral anaerobe, is a major pathogen associated with adult periodontitis, a chronic infective disease that a significant percentage of the human population suffers from.
Altijana Hromić-Jahjefendić, Nina Jajčanin Jozić, Saša Kazazić, Marina Grabar Branilović, Zrinka Karačić, Jörg H Schrittwieser, Krishna Mohan Padmanabha Das, Marko Tomin, Monika Oberer, Karl Gruber, Marija Abramić, Sanja Tomić   +11 more
doaj   +1 more source

DNA Spools under Tension

, 2003
DNA-spools, structures in which DNA is wrapped and helically coiled onto itself or onto a protein core are ubiquitous in nature. We develop a general theory describing the non-equilibrium behavior of DNA-spools under linear tension.
C. G. Baumann, E. Evans, E. Evans, H. Schiessel, H. Yin, I. M. Kulić, J. F. Marko, K. B. Thurmond, R. Bruinsma   +8 more
core   +1 more source

Divergent RNA transcription:A role in promoter unwinding? [PDF]

, 2013
New approaches using biotinylated-psoralen as a probe for investigating DNA structure have revealed new insights into the relationship between DNA supercoiling, transcription and chromatin compaction.
Corless, Samuel, Gilbert, Nick, Naughton, Catherine   +2 more
core   +1 more source

Coumarin‐Augmented Thiazole Hybrids as Dual Anticancer and Antibacterial Agents

Chemical Biology &Drug Design, Volume 107, Issue 2, February 2026.
Compound 13, a coumarin‐thiazole hybrid, is shown engaging the ATP‐binding site of S. aureus GyrB through a novel hydrogen bond with residue SER129. The molecule exhibits dual antibacterial and anticancer activity, supporting its potential as a dual‐target topoisomerase inhibitor.
Islam K. Matar, Magdi E. A. Zaki, Zeinab A. Muhammad, Dahlia A. Awwad, Sami A. Al‐Hussain, Chérif F. Matta, Refaie M. Kassab   +6 more
wiley   +1 more source

DNA denaturation bubbles: free-energy landscape and nucleation/closure rates

, 2015
The issue of the nucleation and slow closure mechanisms of non superhelical stress-induced denaturation bubbles in DNA is tackled using coarse-grained MetaDynamics and Brownian simulations.
Destainville, Nicolas, Manghi, Manoel, Sicard, François   +2 more
core   +1 more source

In silico Analysis of CHD4 Mutations Reveals Domain‐Specific Impacts on Cardiovascular Disorders Among Patients With Rare Diseases

Human Mutation, Volume 2026, Issue 1, 2026.
Chromodomain‐helicase‐DNA‐binding protein 4 (CHD4) is a critical ATP‐dependent chromatin remodeler that plays fundamental roles in transcriptional repression, DNA damage repair, and lineage specification, making it indispensable for cardiovascular development and function.
Apolonia Novillo, Marta Ysbert, Rocío Brea, Alicia María Hidalgo-Estévez, Fadoua El Abdellaoui-Soussi, Pablo Gómez-del Arco, Hannah Wesley   +6 more
wiley   +1 more source