Results 61 to 70 of about 7,352 (214)

Torsional stress can regulate the unwrapping of two outer half superhelical turns of nucleosomal DNA

, 2021
Torsional stress has a significant impact on the structure and stability of the nucleosome. RNA polymerase imposes torsional stress on the DNA in chromatin and unwraps the DNA from the nucleosome to access the genetic information encoded in the DNA. To
1008054, 1008055, Kono, Hidetoshi, 1008056, 1008057, Ishida, Hisashi, Hidetoshi, Kono, Hisashi, Ishida   +7 more
core   +1 more source

Bubble statistics and positioning in superhelically stressed DNA [PDF]

Physical Review E, 2011
We present a general framework to study the thermodynamic denaturation of double-stranded DNA under superhelical stress. We report calculations of position- and size-dependent opening probabilities for bubbles along the sequence. Our results are obtained from transfer-matrix solutions of the Zimm-Bragg model for unconstrained DNA and of a self ...
Jost, Daniel, Zubair, Asif, Everaers, Ralf   +2 more
openaire   +4 more sources

Accessing New Phenanthroline–Oxazine Scaffolds as Copper‐Dependent DNA Damaging Probes

ChemBioChem, Volume 27, Issue 8, April 2026.
New phenanthroline–oxazine ligands derived from natural amino acids are synthesized through an optimized, predictive strategy. When coordinated to copper, these scaffolds display tunable DNA binding, groove selectivity, and oxidative cleavage activity, revealing clear structure activity relationships and expanding the toolbox of copper‐dependent ...
Rebecca Lynn, Alex Gibney, Eva Delahunt, Stephen MacDonald‐Brown, Carlos Lence, Miles Kenny, Matt Allen, Ravil Khaybullin, Iva Lukac, Andrew Jordan, Andrew Kellett   +10 more
wiley   +1 more source

The superhelical density of nuclear DNA from human cells.

, 1977
Structures resembling nuclei may be released by gently lysing human cells in solutions containing non-ionic detergents and high concentrations of salt. These structures, which we call nucleoids, sediment in sucrose gradients containing the intercalating ...
Cook, Peter, Brazell, IA, Cook, PR
core   +1 more source

Electroacupuncture ameliorates vascular cognitive impairment through SIRT7‐mediated downregulation of H3K18 acetylation‐UBP1 in the hippocampus

Brain‐X, Volume 4, Issue 1, March 2026.
Electroacupuncture (EA) reduces H3K18ac enrichment at the Ubp1 promoter in the hippocampus in chronic cerebral hypoperfusion (CCH) rats by upregulating SIRT7‐mediated deacetylation, thereby suppressing the expression of UBP1. This EA‐dependent epigenetic regulation increases dendritic spine density and enhances long‐term potentiation, leading to ...
Wenju Wang, Sinuo Wang, Zhuoming Zheng, Yajun Cao, Mengquan Tan, Junzi Wang, Jiawei Jian, Yanyi Ding, Liming Chen, Zhongyi Hu, Yuxi Qiu, Changmei Lu, Yuwei Ye, Yangling Zheng, Yaling Dai, Siyuan Song, Minguang Yang, Weilin Liu   +17 more
wiley   +1 more source

Superhelical destabilization in regulatory regions of stress response genes. [PDF]

PLoS Computational Biology, 2008
Stress-induced DNA duplex destabilization (SIDD) analysis exploits the known structural and energetic properties of DNA to predict sites that are susceptible to strand separation under negative superhelical stress.
Huiquan Wang, Craig J Benham
doaj   +1 more source

A novel Porphyromonas gingivalis enzyme: An atypical dipeptidyl peptidase III with an ARM repeat domain. [PDF]

PLoS ONE, 2017
Porphyromonas gingivalis, an asaccharolytic Gram-negative oral anaerobe, is a major pathogen associated with adult periodontitis, a chronic infective disease that a significant percentage of the human population suffers from.
Altijana Hromić-Jahjefendić, Nina Jajčanin Jozić, Saša Kazazić, Marina Grabar Branilović, Zrinka Karačić, Jörg H Schrittwieser, Krishna Mohan Padmanabha Das, Marko Tomin, Monika Oberer, Karl Gruber, Marija Abramić, Sanja Tomić   +11 more
doaj   +1 more source

Genome‐wide Identification and expression analysis of TOR signaling pathway components in apple in response to low nitrogen

The Plant Genome, Volume 19, Issue 1, March 2026.
Abstract Target of rapamycin (TOR) is an evolutionarily conserved serine/threonine kinase that plays a central role in regulating biological growth, development, and stress responses in eukaryotes. However, the TOR signaling pathway has not been thoroughly studied in apple (Malus domestica).
Dehai Liu, Siyuan Cheng, Yanghao Long, Qinyao Jin, Yujie Zhou, Fengwang Ma, Xuan Liu, Xiaoqing Gong   +7 more
wiley   +1 more source

Theoretical study of cruciform states in superhelical DNAs [PDF]

FEBS Letters, 1982
The most probable sites for the attack of singlestrand specific endonucleases in some superhelical DNAs are the centers of the longest palindromic sequences [1,2]. These findings accord with the earlier theoretical prediction that the probability of cruciform states for large palindromes should increase with superhelix density 131.
Vologodskii, A.V., Frank-Kamenetskii, M.D.   +1 more
openaire   +2 more sources

Superhelical DNA of polytene chromosomes Chironomus thummi

, 1988
Предложен микровариант флюоресцентного метода измерения степени суперспиральности 0 ДНК в растворе, гелях и хромосомах. Измерения а ДНК депротеинизированных политенных хромосом свидетельствуют, что на один нуклеосомный повтор приходится 1,84÷1,88 витка ...
Груздев, А.Д., Шурдов, М.А.   +1 more
core   +1 more source