Results 41 to 50 of about 7,436 (214)
DNAIntroduction: Does DNA superhelicity effect nucleic acid interactions with drugs? To test such a possibility, the interactions of the linear and superhelical forms of the pGEX-4T-2 plasmid have been investigated with a newly synthesized compound, 4 ...
Dominika Janiszek +7 more
doaj +1 more source
Molecular dynamics simulations of DNA-free and DNA-bound TAL effectors. [PDF]
PLoS ONE, 2013 TAL (transcriptional activator-like) effectors (TALEs) are DNA-binding proteins, containing a modular central domain that recognizes specific DNA sequences. Recently, the crystallographic studies of TALEs revealed the structure of DNA-recognition domain.
Hua Wan +4 more
doaj +1 more source
Circadian rhythms of superhelical status of DNA in cyanobacteria [PDF]
Proceedings of the National Academy of Sciences, 2007 The cyanobacterium Synechococcus elongatus expresses robust circadian (daily) rhythms under the control of the KaiABC-based core clockwork. Unlike eukaryotic circadian systems characterized thus far, the cyanobacterial clockwork modulates gene expression patterns globally and specific clock ...
Mark A, Woelfle +3 more
openaire +2 more sources
Representation of the superhelical pitches and changes of the distances in the DNA-free and DNA-bound systems. [PDF]
, 2013 (A) The cartoon representation of 11.5 TAL repeats and the DNA. The superhelical pitch of dHax3 is assessed by the distance between the Cα atoms of G303 (Gly303) and G675 (Gly675) (left), and the pitch of DNA by the distance between the C3′ atoms of 1dC ...
Hua Wan (213526) +4 more
core +1 more source
A Biophysical Model of CRISPR/Cas9 Activity for Rational Design of Genome Editing and Gene Regulation. [PDF]
PLoS Computational Biology, 2016 The ability to precisely modify genomes and regulate specific genes will greatly accelerate several medical and engineering applications. The CRISPR/Cas9 (Type II) system binds and cuts DNA using guide RNAs, though the variables that control its on ...
Iman Farasat, Howard M Salis
doaj +1 more source
Transcription of Superhelical DNA from Cell Nuclei [PDF]
European Journal of Biochemistry, 1977 Structures resembling nuclei may be released by gently lysing human or frog cells in solutions containing non‐ionic detergents and 1.95 M NaCl. These structures, or nucleoids, sediment in sucrose gradients containing intercalating agents in the manner characteristic of DNA that is intact, supercoiled and circular.
Colman, A, Cook, P
openaire +3 more sources
A theoretical study of the B-A transition in superhelical DNA [PDF]
, 1986 Теоретически рассмотрено влияние сверхспирализации ДНК на В–А-переход, индуцированный увеличением концентрации спирта в растворе. Все предсказываемые теорией эффекты радикальным образом зависят от параметра, характеризующего изменение угла спирального ...
Пахомов, Д.В. +1 more
core +1 more source
Preferentially quantized linker DNA lengths in Saccharomyces cerevisiae.
PLoS Computational Biology, 2008 The exact lengths of linker DNAs connecting adjacent nucleosomes specify the intrinsic three-dimensional structures of eukaryotic chromatin fibers. Some studies suggest that linker DNA lengths preferentially occur at certain quantized values, differing ...
Ji-Ping Wang +5 more
doaj +1 more source
Specific DNA-RNA Hybrid Recognition by TAL Effectors
Cell Reports, 2012 The transcription activator-like (TAL) effector targets specific host promoter through its central DNA-binding domain, which comprises multiple tandem repeats (TALE repeats).
Ping Yin +6 more
doaj +1 more source
The Structure of the Oligomerization Domain of Lsr2 from Mycobacterium tuberculosis Reveals a Mechanism for Chromosome Organization and Protection [PDF]
, 2012 Lsr2 is a small DNA-binding protein present in mycobacteria and related actinobacteria that regulates gene expression and influences the organization of bacterial chromatin.
Isabel Usón (319527) +32 more
core +1 more source