Results 21 to 30 of about 11,225 (206)

A helicoidal transfer matrix model for inhomogeneous DNA melting [PDF]

, 2006
An inhomogeneous helicoidal nearest-neighbor model with continuous degrees of freedom is shown to predict the same DNA melting properties as traditional long-range Ising models, for free DNA molecules in solution, as well as superhelically stressed DNA ...
D. Poland, Tom Michoel, W. Press, Yves Van de Peer   +3 more
core   +2 more sources

Helical antimicrobial peptides assemble into protofibril scaffolds that present ordered dsDNA to TLR9

Nature Communications, 2019
Amphihelical antimicrobial peptides (AMPs) are bactericidal host defense factors, but their function as immunomodulators is emerging. Here the authors show that several AMPs organize DNA into periodic nanocrystals by self-assembling into superhelical ...
Ernest Y. Lee, Changsheng Zhang, Jeremy Di Domizio, Fan Jin, Will Connell, Mandy Hung, Nicolas Malkoff, Veronica Veksler, Michel Gilliet, Pengyu Ren, Gerard C. L. Wong   +10 more
doaj   +1 more source

Non-canonical DNA structures: Diversity and disease association

Frontiers in Genetics, 2022
A complete understanding of DNA double-helical structure discovered by James Watson and Francis Crick in 1953, unveil the importance and significance of DNA.
Aparna Bansal, Aparna Bansal, Shikha Kaushik, Shikha Kaushik, Shrikant Kukreti   +4 more
doaj   +1 more source

Chromatin remodeller SMARCA4 recruits topoisomerase 1 and suppresses transcription-associated genomic instability

Nature Communications, 2016
Topoisomerase 1 (TOP1) relieves superhelical tension when DNA strands are unwound during transcription. Here, Husain et al. report that SMARCA4, an ATP-dependent chromatin remodeller, is associated with TOP1 and suppresses transcription-associated ...
Afzal Husain, Nasim A. Begum, Takako Taniguchi, Hisaaki Taniguchi, Maki Kobayashi, Tasuku Honjo   +5 more
doaj   +1 more source

Application of Plasmid Engineering to Enhance Yield and Quality of Plasmid for Vaccine and Gene Therapy

Bioengineering, 2019
There is an increased interest in plasmid DNA as therapeutics. This is evident in the number of ongoing clinical trials involving the use of plasmid DNA.
Olusegun Folarin, Darren Nesbeth, John M. Ward, Eli Keshavarz-Moore   +3 more
doaj   +1 more source

Free energy profiles for unwrapping the outer superhelical turn of nucleosomal DNA.

PLoS Computational Biology, 2018
The eukaryotic genome is packaged into a nucleus in the form of chromatin. The fundamental structural unit of chromatin is a protein-DNA complex, the nucleosome, where 146 or 147 base pairs of DNA wrap 1.75 times around a histone core.
Hidetoshi Kono, Shun Sakuraba, Hisashi Ishida   +2 more
doaj   +1 more source

Structural Coupling between RNA Polymerase Composition and DNA Supercoiling in Coordinating Transcription: a Global Role for the Omega Subunit?

mBio, 2011
In growing bacterial cells, the global reorganization of transcription is associated with alterations of RNA polymerase composition and the superhelical density of the DNA.
Marcel Geertz, Andrew Travers, Sanja Mehandziska, Patrick Sobetzko, Sarath Chandra Janga, Nobuo Shimamoto, Georgi Muskhelishvili   +6 more
doaj   +1 more source

Correction: Free energy profiles for unwrapping the outer superhelical turn of nucleosomal DNA. [PDF]

PLoS Computational Biology, 2019
[This corrects the article DOI: 10.1371/journal.pcbi.1006024.].
Hidetoshi Kono, Shun Sakuraba, Hisashi Ishida   +2 more
doaj   +1 more source

Interaction of the Escherichia coli HU Protein with Various Topological Forms of DNA

Biomolecules, 2021
E. coli histone-like protein HU has been shown to interact with different topological forms of DNA. Using radiolabeled HU, we examine the effects of DNA supercoiling on HU–DNA interactions.
Li Huang, Zhenfeng Zhang, Roger McMacken
doaj   +1 more source

Functional instability allows access to DNA in longer transcription Activator-Like effector (TALE) arrays

eLife, 2019
Transcription activator-like effectors (TALEs) bind DNA through an array of tandem 34-residue repeats. How TALE repeat domains wrap around DNA, often extending more than 1.5 helical turns, without using external energy is not well understood.
Kathryn Geiger-Schuller, Jaba Mitra, Taekjip Ha, Doug Barrick   +3 more
doaj   +1 more source