Results 31 to 40 of about 11,225 (206)
Unpaired bases in superhelical DNA: kinetic evidence [PDF]
Nucleic Acids Research, 1974 Kinetic analysis of the early, fast reaction of superhelical DNA with formaldehyde reveals that this region or regions is 56% "single strand like" in character. Hydrogen-tritium exchange studies coupled with other considerations show that this reaction is not due to a difference in conformational motility between form I and form II molecules, but is ...
R J, Jacob, J, Lebowitz, M P, Printz
openaire +2 more sources
Nucleosome-CHD4 chromatin remodeler structure maps human disease mutations
eLife, 2020 Chromatin remodeling plays important roles in gene regulation during development, differentiation and in disease. The chromatin remodeling enzyme CHD4 is a component of the NuRD and ChAHP complexes that are involved in gene repression.
Lucas Farnung +2 more
doaj +1 more source
Molecular dynamics simulations of DNA-free and DNA-bound TAL effectors. [PDF]
PLoS ONE, 2013 TAL (transcriptional activator-like) effectors (TALEs) are DNA-binding proteins, containing a modular central domain that recognizes specific DNA sequences. Recently, the crystallographic studies of TALEs revealed the structure of DNA-recognition domain.
Hua Wan +4 more
doaj +1 more source
Promoter unwinding and promoter clearance by RNA polymerase: Detection by single-molecule DNA nanomanipulation [PDF]
, 2004 By monitoring the end-to-end extension of a mechanically stretched, supercoiled, single DNA molecule, we have been able directly to observe the change in extension associated with unwinding of approximately one turn of promoter DNA by RNA polymerase ...
Revyakin, A. +2 more
core +1 more source
A Biophysical Model of CRISPR/Cas9 Activity for Rational Design of Genome Editing and Gene Regulation. [PDF]
PLoS Computational Biology, 2016 The ability to precisely modify genomes and regulate specific genes will greatly accelerate several medical and engineering applications. The CRISPR/Cas9 (Type II) system binds and cuts DNA using guide RNAs, though the variables that control its on ...
Iman Farasat, Howard M Salis
doaj +1 more source
The size of the nucleosome [PDF]
, 2011 The structural origin of the size of the 11 nm nucleosomal disc is addressed. On the nanometer length-scale the organization of DNA as chromatin in the chromosomes involves a coiling of DNA around the histone core of the nucleosome.
A. Travers +3 more
core +2 more sources
Transcription of Superhelical DNA from Cell Nuclei [PDF]
European Journal of Biochemistry, 1977 Structures resembling nuclei may be released by gently lysing human or frog cells in solutions containing non‐ionic detergents and 1.95 M NaCl. These structures, or nucleoids, sediment in sucrose gradients containing intercalating agents in the manner characteristic of DNA that is intact, supercoiled and circular.
Colman, A, Cook, P
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Long-range correlations in the mechanics of small DNA circles under topological stress revealed by multi-scale simulation [PDF]
, 2016 It is well established that gene regulation can be achieved through activator and repressor proteins that bind to DNA and switch particular genes on or off, and that complex metabolic networks deter- mine the levels of transcription of a given gene at a ...
Agnes Noy +9 more
core +3 more sources
Preferentially quantized linker DNA lengths in Saccharomyces cerevisiae.
PLoS Computational Biology, 2008 The exact lengths of linker DNAs connecting adjacent nucleosomes specify the intrinsic three-dimensional structures of eukaryotic chromatin fibers. Some studies suggest that linker DNA lengths preferentially occur at certain quantized values, differing ...
Ji-Ping Wang +5 more
doaj +1 more source
Interactions of Cisplatin and Daunorubicin at the chromatin level [PDF]
, 2020 Unexpectedly, the widely used anticancer agents Cisplatin (Cis-Pt) and Daunorubicin (Dauno) exhibited cell type- and concentration-dependent synergy or antagonism in vitro.
Bacsó, Zsolt +7 more
core +2 more sources