Results 31 to 40 of about 7,352 (214)

S1-Type Endonuclease 2 in Dedifferentiating Arabidopsis Protoplasts: Translocation to the Nucleus in Senescing Protoplasts Is Associated with De-Glycosylation. [PDF]

open access: yesPLoS ONE, 2017
Cell dedifferentiation characterizes the transition of leaf cells to protoplasts and is accompanied by global chromatin decondensation. Here we show that in Arabidopsis, chromocentric chromatin undergoes prompt and gradual decondensation upon ...
Yemima Givaty-Rapp   +3 more
doaj   +1 more source

Helical antimicrobial peptides assemble into protofibril scaffolds that present ordered dsDNA to TLR9

open access: yesNature Communications, 2019
Amphihelical antimicrobial peptides (AMPs) are bactericidal host defense factors, but their function as immunomodulators is emerging. Here the authors show that several AMPs organize DNA into periodic nanocrystals by self-assembling into superhelical ...
Ernest Y. Lee   +10 more
doaj   +1 more source

Non-canonical DNA structures: Diversity and disease association

open access: yesFrontiers in Genetics, 2022
A complete understanding of DNA double-helical structure discovered by James Watson and Francis Crick in 1953, unveil the importance and significance of DNA.
Aparna Bansal   +4 more
doaj   +1 more source

Stochastic Simulation of the Kinetics of Multiple Interacting Nucleic Acid Strands [PDF]

open access: yes, 2013
DNA nanotechnology is an emerging field which utilizes the unique structural properties of nucleic acids in order to build nanoscale devices, such as logic gates, motors, walkers, and algorithmic structures. Predicting the structure and interactions of a
Schaeffer, Joseph Malcolm
core   +1 more source

Chromatin remodeller SMARCA4 recruits topoisomerase 1 and suppresses transcription-associated genomic instability

open access: yesNature Communications, 2016
Topoisomerase 1 (TOP1) relieves superhelical tension when DNA strands are unwound during transcription. Here, Husain et al. report that SMARCA4, an ATP-dependent chromatin remodeller, is associated with TOP1 and suppresses transcription-associated ...
Afzal Husain   +5 more
doaj   +1 more source

Application of Plasmid Engineering to Enhance Yield and Quality of Plasmid for Vaccine and Gene Therapy

open access: yesBioengineering, 2019
There is an increased interest in plasmid DNA as therapeutics. This is evident in the number of ongoing clinical trials involving the use of plasmid DNA.
Olusegun Folarin   +3 more
doaj   +1 more source

The B – A transition in superhelical DNA

open access: yesNucleic Acids Research, 1990
Relaxation of a DNA superhelical stress due to the B to A transition induced by trifluoroethanol has been studied by assessing the change of DNA orientation in a flow gradient. Using DNAs of different superhelical densities, a decrease in the winding angle during the B----A shift of DNA was found to be 1.5 degrees per base pair in solution.
, Krylov DYu, V L, Makarov, V I, Ivanov
openaire   +3 more sources

Structural Coupling between RNA Polymerase Composition and DNA Supercoiling in Coordinating Transcription: a Global Role for the Omega Subunit?

open access: yesmBio, 2011
In growing bacterial cells, the global reorganization of transcription is associated with alterations of RNA polymerase composition and the superhelical density of the DNA.
Marcel Geertz   +6 more
doaj   +1 more source

Interaction of the Escherichia coli HU Protein with Various Topological Forms of DNA

open access: yesBiomolecules, 2021
E. coli histone-like protein HU has been shown to interact with different topological forms of DNA. Using radiolabeled HU, we examine the effects of DNA supercoiling on HU–DNA interactions.
Li Huang, Zhenfeng Zhang, Roger McMacken
doaj   +1 more source

Functional instability allows access to DNA in longer transcription Activator-Like effector (TALE) arrays

open access: yeseLife, 2019
Transcription activator-like effectors (TALEs) bind DNA through an array of tandem 34-residue repeats. How TALE repeat domains wrap around DNA, often extending more than 1.5 helical turns, without using external energy is not well understood.
Kathryn Geiger-Schuller   +3 more
doaj   +1 more source

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