Results 91 to 100 of about 7,436 (214)
A pH-dependent structural transition in the homopurine-homopyrimidine tract in superhelical DNA [PDF]
, 1986 С помощью двумерного электрофореза обнаружен структурный переход нового типа в гомопурин-гомопиримидиновом участке в сверхспиральной ДНК. В отличие от других исследованных переходов, этот переход сильно зависит от рН, что проявляется в уменьшении ...
Миркин, С.М. +2 more
core +3 more sources
ChemBioChem, Volume 26, Issue 24, December 11, 2025.Mercury (Hg) is a possible risk factor for Alzheimer's disease, where neuronal death is related to amyloid brain plaques containing aggregated amyloid‐β (Aβ) peptides. We show that equimolar Hg(I) or Hg(II) ions inhibit normal Aβ aggregation. Hg(II) binds Aβ(1–40) with an apparent binding affinity 28 ± 8 μM.
Elina Berntsson +7 more
wiley +1 more source
Spectrofluorometric measurement of the binding of ethidium to superhelical DNA from cell nuclei. [PDF]
, 1978 Structures retaining many of the morphological features of nuclei may be released by lysing HeLa cells in solutions containing non-ionic detergents and high concentrations of salt. These nucleoids contain few chromatin proteins.
Cook, Peter, Brazell, IA, Cook, PR
core +1 more source
BMC Bioinformatics, 2006 Background In our previous studies, we found that the sites in prokaryotic genomes which are most susceptible to duplex destabilization under the negative superhelical stresses that occur in vivo are statistically highly significantly associated with ...
Benham Craig J, Wang Huiquan
doaj +1 more source
Characterization of nuclear structures containing superhelical DNA
Journal of Cell Science, 1976 ABSTRACT Structures resembling nuclei but depleted of protein may be released by gently lysing cells in solutions containing non-ionic detergents and high concentrations of salt. These nucleoids sediment in gradients containing intercalating agents in a manner characteristic of DNA that is intact, supercoiled and circular.
Cook, P, Brazell, I, Jost, E
openaire +3 more sources
The Concise Guide to PHARMACOLOGY 2025/26: Ion channels
British Journal of Pharmacology, Volume 182, Issue S1, Page S152-S241, December 2025.The Concise Guide to Pharmacology 2025/26 marks the seventh edition in this series of biennial publications in the British Journal of Pharmacology. Presented in landscape format, the guide provides a comparative overview of the pharmacology of drug target families. The concise nature of the Concise Guide refers to the style of presentation, being clear,
Stephen P. H. Alexander +86 more
wiley +1 more source
HIV chromatin is a preferred target for drugs that bind in the DNA minor groove.
PLoS ONE, 2019 The HIV genome is rich in A but not G or U and deficient in C. This nucleotide bias controls HIV phenotype by determining the highly unusual composition of all major HIV proteins.
Clayton K Collings +3 more
doaj +1 more source
Frontiers in Immunology, 2020 Pathological self-assembly is a concept that is classically associated with amyloids, such as amyloid-β (Aβ) in Alzheimer's disease and α-synuclein in Parkinson's disease.
Ernest Y. Lee +8 more
doaj +1 more source
Histones and histone variant families in prokaryotes
Nature CommunicationsHistones are important chromatin-organizing proteins in eukaryotes and archaea. They form superhelical structures around which DNA is wrapped. Recent studies have shown that some archaea and bacteria contain alternative histones that exhibit different ...
Samuel Schwab +8 more
doaj +1 more source
Ultraviolet light irradiation of PM2 superhelical DNA
Nucleic Acids Research, 1977 Superhelical PM2 DNA can be photochemically modified by u.v. irradiation. The variation of S20,w with dose shows the following characteristics. There is a linear increase from 28 to 31s produced by a low dose of u.v. irradiation (4,000 ergs/mm2). A plateau in S20,w occurs between 4,000 and 10,000 ergs/mm2.
M, Woodworth-Gutai +3 more
openaire +3 more sources