Results 51 to 60 of about 11,463 (183)
The Concise Guide to PHARMACOLOGY 2025/26: Ion channels
British Journal of Pharmacology, Volume 182, Issue S1, Page S152-S241, December 2025.The Concise Guide to Pharmacology 2025/26 marks the seventh edition in this series of biennial publications in the British Journal of Pharmacology. Presented in landscape format, the guide provides a comparative overview of the pharmacology of drug target families. The concise nature of the Concise Guide refers to the style of presentation, being clear,
Stephen P. H. Alexander +86 more
wiley +1 more source
Architectural Organization of Dinoflagellate Liquid Crystalline Chromosomes
Microorganisms, 2019 Dinoflagellates have some of the largest genome sizes, but lack architectural nucleosomes. Their liquid crystalline chromosomes (LCCs) are the only non-architectural protein-mediated chromosome packaging systems, having high degrees of DNA superhelicity,
Joseph Tin Yum Wong
doaj +1 more source
A new family of intrinsically disordered proteins: structural characterization of the major phasin PhaF from Pseudomonas putida KT2440. [PDF]
PLoS ONE, 2013 Phasins are intracellular polyhydroxyalkanoat4e (PHA)-associated proteins involved in the stabilization of these bacterial carbon storage granules. Despite its importance in PHA metabolism and regulation, only few reports have focused so far on the ...
Beatriz Maestro +5 more
doaj +1 more source
, 2003 DNA-spools, structures in which DNA is wrapped and helically coiled onto itself or onto a protein core are ubiquitous in nature. We develop a general theory describing the non-equilibrium behavior of DNA-spools under linear tension.
C. G. Baumann +8 more
core +1 more source
Structural ultrafast dynamics of macromolecules: diffraction of free DNA and effect of hydration [PDF]
, 2009 Of special interest in molecular biology is the study of structural and conformational changes which are free of the additional effects of the environment.
Lin, Milo M. +2 more
core +1 more source
Transferability and Reproducibility of the HepaRG CometChip Assay
Environmental and Molecular Mutagenesis, Volume 66, Issue 9, Page 478-491, November 2025.ABSTRACT This interlaboratory evaluation of HepaRG CometChip was conducted to assess transferability and reproducibility of this new approach methodology (NAM) across four laboratories. Concentrations inducing up to ~70% relative cytotoxicity were determined by the organizing laboratory, and frozen chemical formulation blocks were sent to each ...
Leslie Recio +10 more
wiley +1 more source
Probing the (H3-H4)(2) histone tetramer structure using pulsed EPR spectroscopy combined with site-directed spin labelling [PDF]
, 2009 The (H3-H4)2 histone tetramer forms the central core of nucleosomes and, as such, plays a prominent role in assembly, disassembly and positioning of nucleosomes.
Bowman, A. +4 more
core +5 more sources
Journal of Extracellular Vesicles, Volume 14, Issue 11, November 2025.H3C14 modulates gemcitabine metabolism and is selectively excluded via extracellular vesicles (EVs) in gemcitabine (GCB)‐resistant bladder cancer. CD9⁺/CD63⁺/CD81⁺ EVs (Transport‐EVs) transmit resistance, whereas CD147⁺/LAMB1⁺ EVs (Excretion‐EVs) excrete tumour‐suppressive cargos, highlighting the functional divergence of EV subtypes in GCB resistance.
Cheng‐Shuo Huang +5 more
wiley +1 more source
PLoS ONE, 2019 The restricted access of regulatory factors to their binding sites on DNA wrapped around the nucleosomes is generally interpreted in terms of molecular shielding exerted by nucleosomal structure and internucleosomal interactions.
Rosevalentine Bosire +9 more
doaj +1 more source
Superhelical destabilization in regulatory regions of stress response genes. [PDF]
PLoS Computational Biology, 2008 Stress-induced DNA duplex destabilization (SIDD) analysis exploits the known structural and energetic properties of DNA to predict sites that are susceptible to strand separation under negative superhelical stress.
Huiquan Wang, Craig J Benham
doaj +1 more source