Results 61 to 70 of about 2,039,836 (177)

Free energy profile for unwrapping outer superhelical turn of CENP-A nucleosome

open access: yesBiophysics and Physicobiology, 2019
Eukaryotic genome is packaged in a nucleus in the form of chromatin. The fundamental structural unit of the chromatin is the protein-DNA complex, nucleosome, where DNA of about 150 bp is wrapped around a histone core almost twice.
Hidetoshi Kono   +2 more
doaj   +1 more source

Structural ultrafast dynamics of macromolecules: diffraction of free DNA and effect of hydration [PDF]

open access: yes, 2009
Of special interest in molecular biology is the study of structural and conformational changes which are free of the additional effects of the environment.
Lin, Milo M.   +2 more
core   +1 more source

A Superhelical Spiral in the Escherichia coli DNA Gyrase A C-terminal Domain Imparts Unidirectional Supercoiling Bias*

open access: yesJournal of Biological Chemistry, 2005
DNA gyrase is unique among type II topoisomerases in that its DNA supercoiling activity is unidirectional. The C-terminal domain of the gyrase A subunit (GyrA-CTD) is required for this supercoiling bias.
A. Ruthenburg   +3 more
semanticscholar   +1 more source

3D Printing of Conducting Polymer Hydrogels for Electrostimulation‐Assisted Tissue Engineering

open access: yesAdvanced Materials, Volume 37, Issue 36, September 11, 2025.
This review highlights nanosized inherently conducting polymers (ICPs) as promising ink constituents for 3D printing of conducting hydrogel (CH)‐based electrostimulation (ES) devices. ICP‐based ink formulation, 3D printing, and solidification strategies are discussed, along with the application of 3D‐printed ICP‐based CHs as ES platforms for regulating
Chien Minh Tran   +6 more
wiley   +1 more source

Insights Into the Conformational Dynamics of the Cytoplasmic Domain of Metal‐Sensing Sensor Histidine Kinase ZraS

open access: yesProteins: Structure, Function, and Bioinformatics, Volume 93, Issue 9, Page 1465-1480, September 2025.
ABSTRACT ZraS is a metal sensor integral to ZraPSR, a two‐component signaling system found in enterobacters. It belongs to a family of bifunctional sensor histidine kinases (SHKs) and is speculated to sense zinc‐induced stress on the bacterial envelope.
Nilima Mahapatra   +3 more
wiley   +1 more source

Hopping into a hot seat: Role of DNA structural features on IS5-mediated gene activation and inactivation under stress. [PDF]

open access: yesPLoS ONE, 2017
Insertion sequence elements (IS elements) are proposed to play major roles in shaping the genetic and phenotypic landscapes of prokaryotic cells. Recent evidence has raised the possibility that environmental stress conditions increase IS hopping into new
M Zafri Humayun   +4 more
doaj   +1 more source

Divergent RNA transcription:A role in promoter unwinding? [PDF]

open access: yes, 2013
New approaches using biotinylated-psoralen as a probe for investigating DNA structure have revealed new insights into the relationship between DNA supercoiling, transcription and chromatin compaction.
Corless, Samuel   +2 more
core   +1 more source

A pH-dependent structural transition in the homopurine-homopyrimidine tract in superhelical DNA.

open access: yesJournal of Biomolecular Structure and Dynamics, 1985
We have inserted the 509-bp-long fragment of sea urchin P. miliaris histone gene spacer region into plasmid pUC19. The fragment contains the 60-bp-long homopurine-homopyrimidine tract that is known to be hypersensitive to the S1 endonuclease.
V. Lyamichev   +2 more
semanticscholar   +1 more source

Circularly polarized luminescence from supramolecular assemblies based on small molecules

open access: yesSmart Molecules, Volume 3, Issue 3, September 2025.
This minireview outlines the recent advances of circularly polarized luminescence (CPL)‐active supramolecular assemblies based on small molecules. It covers fundamental concepts of CPL, typical design strategies of CPL‐active materials—including the assembly of chiral luminophores, the assembly of chiral components and achiral luminophores, and the ...
Xinyu Liu   +5 more
wiley   +1 more source

Helping Eve Overcome ADAM: G-Quadruplexes in the ADAM-15 Promoter as New Molecular Targets for Breast Cancer Therapeutics

open access: yesMolecules, 2013
ADAM-15, with known zymogen, secretase, and disintegrin activities, is a catalytically active member of the ADAM family normally expressed in early embryonic development and aberrantly expressed in various cancers, including breast, prostate and lung ...
Robert V. Brown   +3 more
doaj   +1 more source

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