Results 71 to 80 of about 2,039,836 (177)

Conformational change-induced repeat domain expansion regulates Rap phosphatase quorum-sensing signal receptors. [PDF]

PLoS Biology, 2013
The large family of Gram-positive quorum-sensing receptors known as the RNPP proteins consists of receptors homologous to the Rap, NprR, PlcR, and PrgX proteins that are regulated by imported oligopeptide autoinducers.
Vijay Parashar, Philip D Jeffrey, Matthew B Neiditch   +2 more
doaj   +1 more source

Clinical Features of Seven COL2A1 Variations in Chinese Children With Type II Collagen Disorders

Acta Paediatrica, Volume 114, Issue 7, Page 1720-1730, July 2025.
ABSTRACT Aim Type II collagen, encoded by the collagen type II alpha 1 (COL2A1) gene, is crucial for the structure of cartilage. This study aims to improve our understanding of Spondyloepiphyseal Dysplasia Congenita (SEDC) caused by mutations in COL2A1. We also aim to evaluate the safety and efficacy of growth hormone (GH) therapy in two SEDC patients.
Shumin Zhan, Qin He, Jinna Yuan, Xiaoqin Xu, Ke Huang, Guanping Dong, Junfen Fu, Dingwen Wu, Wei Wu   +8 more
wiley   +1 more source

A cellular system to study responses to a collision between the transcription complex and a protein‐bound nick in the DNA template

FEBS Letters, Volume 599, Issue 12, Page 1749-1759, June 2025.
We present the cellular transcription‐coupled Flp‐nick system allowing the introduction of a Top1‐mimicking cleavage complex (Flpcc) at a Flp recognition target site within a controllable LacZ gene. LacZ transcription leads to the collision of RNA polymerase II (RNAPII) with Flpcc, and this causes RNAPII stalling, ubiquitination, and degradation.
Petra Herring, Morten Roedgaard, Camilla Myrup Holst, Helene Christensen, Birgitta R. Knudsen, Lotte Bjergbaek, Anni Hangaard Andersen   +6 more
wiley   +1 more source

Dimensional Coupling in Synergistic Bio‐Nano Growth Systems

MedComm – Biomaterials and Applications, Volume 4, Issue 2, June 2025.
Dimensional Evolution in Bio‐Nano Synergistic Systems: Proteins shrink into fibrils while gold ions expand into nanoparticles, minimizing bio‐nano interface interactions for enhanced hybrid functionality. This study highlights a competitive yet synergistic growth mechanism, offering insights for the rational design of bio‐nano materials with clinical ...
Ming Yuan, Xinmin Zhao, Jun Guo, Feng Zhang   +3 more
wiley   +1 more source

Cytotoxicity of psammaplin A from a two-sponge association may correlate with the inhibition of DNA replication

BMC Cancer, 2004
Background SV40 DNA replication system is a very useful tool to understand the mechanism of replication, which is a tightly regulated process. Many environmental and cellular factors can induce cell cycle arrest or apoptosis by inhibiting DNA replication.
You Song, Yoon Hyun, Park Jang-Su, Kim Dong-Kyoo, Ryu Seung, Ahn Eun-Young, Jiang Yahong, Lee Burm-Jong, Lee Dong, Jung Jee H   +9 more
doaj   +1 more source

Interplay between DNA sequence and negative superhelicity drives R-loop structures. [PDF]

, 2019
R-loops are abundant three-stranded nucleic-acid structures that form in cis during transcription. Experimental evidence suggests that R-loop formation is affected by DNA sequence and topology. However, the exact manner by which these factors interact to
Benham, Craig J, Chedin, Frederic, Hartono, Stella R, Malig, Maika, Stolz, Robert, Sulthana, Shaheen   +5 more
core  

Using a stable protein scaffold to display peptides that bind to alpha‐synuclein fibrils

Protein Science, Volume 34, Issue 6, June 2025.
Abstract Amyloid fibrils are ordered aggregates that are a pathological hallmark of many neurodegenerative disorders including Alzheimer's disease and Parkinson's disease. The process of amyloid formation involves a complex cascade by which soluble monomeric protein converts to insoluble, ordered aggregates (amyloid fibrils).
Samuel Bismut, Matthias M. Schneider, Masashi Miyasaki, Yuqing Feng, Ellis J. Wilde, M. Dylan Gunawardena, Tuomas P. J. Knowles, Gabrielle S. Kaminski Schierle, Laura S. Itzhaki, Janet R. Kumita   +9 more
wiley   +1 more source

Structural Basis and Mechanism of a Unique Haemophore in the Haem‐Iron Acquisition by Riemerella anatipestifer

Advanced Science, Volume 12, Issue 13, April 3, 2025.
This study reveals the structural basis and mechanism of RhuH as a haemophore in Riemerella anatipestifer. Secreted by outer membrane vesicles (OMVs), RhuH captures haem with high affinity from host hemoglobin in two forms: a) released from OMVs, binding and transferring haem to outer membrane receptor, and b) haem‐bound on the OMVs surface, returning ...
Mengying Wang, Dandan Zhang, Xiu Tian, Jiangyang Tong, Yizhou Yao, Mingshu Wang, Dekang Zhu, Renyong Jia, Shun Chen, Xinxin Zhao, Shaqiu Zhang, Juan Huang, Xumin Ou, Bin Tian, Di Sun, Yu He, Zhen Wu, Songying Ouyang, Mafeng Liu, Anchun Cheng   +19 more
wiley   +1 more source

HIV chromatin is a preferred target for drugs that bind in the DNA minor groove.

PLoS ONE, 2019
The HIV genome is rich in A but not G or U and deficient in C. This nucleotide bias controls HIV phenotype by determining the highly unusual composition of all major HIV proteins.
Clayton K Collings, Donald W Little, Samuel J Schafer, John N Anderson   +3 more
doaj   +1 more source

Functional Reciprocity of Amyloids and Antimicrobial Peptides: Rethinking the Role of Supramolecular Assembly in Host Defense, Immune Activation, and Inflammation

Frontiers in Immunology, 2020
Pathological self-assembly is a concept that is classically associated with amyloids, such as amyloid-β (Aβ) in Alzheimer's disease and α-synuclein in Parkinson's disease.
Ernest Y. Lee, Ernest Y. Lee, Yashes Srinivasan, Jaime de Anda, Lauren K. Nicastro, Çagla Tükel, Gerard C. L. Wong, Gerard C. L. Wong, Gerard C. L. Wong   +8 more
doaj   +1 more source