Results 81 to 90 of about 11,463 (183)

Using a stable protein scaffold to display peptides that bind to alpha‐synuclein fibrils

Protein Science, Volume 34, Issue 6, June 2025.
Abstract Amyloid fibrils are ordered aggregates that are a pathological hallmark of many neurodegenerative disorders including Alzheimer's disease and Parkinson's disease. The process of amyloid formation involves a complex cascade by which soluble monomeric protein converts to insoluble, ordered aggregates (amyloid fibrils).
Samuel Bismut, Matthias M. Schneider, Masashi Miyasaki, Yuqing Feng, Ellis J. Wilde, M. Dylan Gunawardena, Tuomas P. J. Knowles, Gabrielle S. Kaminski Schierle, Laura S. Itzhaki, Janet R. Kumita   +9 more
wiley   +1 more source

Cytotoxicity of psammaplin A from a two-sponge association may correlate with the inhibition of DNA replication

BMC Cancer, 2004
Background SV40 DNA replication system is a very useful tool to understand the mechanism of replication, which is a tightly regulated process. Many environmental and cellular factors can induce cell cycle arrest or apoptosis by inhibiting DNA replication.
You Song, Yoon Hyun, Park Jang-Su, Kim Dong-Kyoo, Ryu Seung, Ahn Eun-Young, Jiang Yahong, Lee Burm-Jong, Lee Dong, Jung Jee H   +9 more
doaj   +1 more source

Theoretical study of cruciform states in superhelical DNAs [PDF]

FEBS Letters, 1982
The most probable sites for the attack of singlestrand specific endonucleases in some superhelical DNAs are the centers of the longest palindromic sequences [1,2]. These findings accord with the earlier theoretical prediction that the probability of cruciform states for large palindromes should increase with superhelix density 131.
Vologodskii, A.V., Frank-Kamenetskii, M.D.   +1 more
openaire   +2 more sources

Structural Basis and Mechanism of a Unique Haemophore in the Haem‐Iron Acquisition by Riemerella anatipestifer

Advanced Science, Volume 12, Issue 13, April 3, 2025.
This study reveals the structural basis and mechanism of RhuH as a haemophore in Riemerella anatipestifer. Secreted by outer membrane vesicles (OMVs), RhuH captures haem with high affinity from host hemoglobin in two forms: a) released from OMVs, binding and transferring haem to outer membrane receptor, and b) haem‐bound on the OMVs surface, returning ...
Mengying Wang, Dandan Zhang, Xiu Tian, Jiangyang Tong, Yizhou Yao, Mingshu Wang, Dekang Zhu, Renyong Jia, Shun Chen, Xinxin Zhao, Shaqiu Zhang, Juan Huang, Xumin Ou, Bin Tian, Di Sun, Yu He, Zhen Wu, Songying Ouyang, Mafeng Liu, Anchun Cheng   +19 more
wiley   +1 more source

Promoter prediction and annotation of microbial genomes based on DNA sequence and structural responses to superhelical stress

BMC Bioinformatics, 2006
Background In our previous studies, we found that the sites in prokaryotic genomes which are most susceptible to duplex destabilization under the negative superhelical stresses that occur in vivo are statistically highly significantly associated with ...
Benham Craig J, Wang Huiquan
doaj   +1 more source

Identification, characterization and classification of prokaryotic nucleoid‐associated proteins

Molecular Microbiology, Volume 123, Issue 3, Page 206-217, March 2025.
Nucleoid‐associated proteins (NAPs) structure DNA by either bending, wrapping, bridging, or forming protein filaments on the DNA. We review newly identified NAPs and provide a list of simple biochemical assays to study the DNA‐structuring properties of novel NAPs. Abstract Common throughout life is the need to compact and organize the genome.
Samuel Schwab, Remus T. Dame
wiley   +1 more source

HIV chromatin is a preferred target for drugs that bind in the DNA minor groove.

PLoS ONE, 2019
The HIV genome is rich in A but not G or U and deficient in C. This nucleotide bias controls HIV phenotype by determining the highly unusual composition of all major HIV proteins.
Clayton K Collings, Donald W Little, Samuel J Schafer, John N Anderson   +3 more
doaj   +1 more source

Functional Reciprocity of Amyloids and Antimicrobial Peptides: Rethinking the Role of Supramolecular Assembly in Host Defense, Immune Activation, and Inflammation

Frontiers in Immunology, 2020
Pathological self-assembly is a concept that is classically associated with amyloids, such as amyloid-β (Aβ) in Alzheimer's disease and α-synuclein in Parkinson's disease.
Ernest Y. Lee, Ernest Y. Lee, Yashes Srinivasan, Jaime de Anda, Lauren K. Nicastro, Çagla Tükel, Gerard C. L. Wong, Gerard C. L. Wong, Gerard C. L. Wong   +8 more
doaj   +1 more source

Regulation of DNA Topology in Archaea: State of the Art and Perspectives

Molecular Microbiology, Volume 123, Issue 3, Page 245-264, March 2025.
DNA topoisomerases are ubiquitous enzymes that play a crucial role in regulating DNA supercoiling which affects fundamental biological processes involving DNA. In this review, we summarize the current understanding of regulation of supercoiling by DNA topoisomerases in the third domain of life, the Archaea, with a particular focus on three key model ...
Paul Villain, Tamara Basta
wiley   +1 more source

Transcriptional Silencing by TsrA in the Evolution of Pathogenic Vibrio cholerae Biotypes

mBio, 2020
Vibrio cholerae is a globally important pathogen responsible for the severe epidemic diarrheal disease called cholera. The current and ongoing seventh pandemic of cholera is caused by El Tor strains, which have completely replaced the sixth-pandemic ...
Florence Caro, José A. Caro, Nicole M. Place, John J. Mekalanos   +3 more
doaj   +1 more source