Results 81 to 90 of about 2,039,836 (177)
Identification, characterization and classification of prokaryotic nucleoid‐associated proteins
Molecular Microbiology, Volume 123, Issue 3, Page 206-217, March 2025.Nucleoid‐associated proteins (NAPs) structure DNA by either bending, wrapping, bridging, or forming protein filaments on the DNA. We review newly identified NAPs and provide a list of simple biochemical assays to study the DNA‐structuring properties of novel NAPs. Abstract Common throughout life is the need to compact and organize the genome.
Samuel Schwab, Remus T. Dame
wiley +1 more source
Transcriptional Silencing by TsrA in the Evolution of Pathogenic
mBio, 2020 Vibrio cholerae is a globally important pathogen responsible for the severe epidemic diarrheal disease called cholera. The current and ongoing seventh pandemic of cholera is caused by El Tor strains, which have completely replaced the sixth-pandemic ...
Florence Caro +3 more
doaj +1 more source
Regulation of DNA Topology in Archaea: State of the Art and Perspectives
Molecular Microbiology, Volume 123, Issue 3, Page 245-264, March 2025.DNA topoisomerases are ubiquitous enzymes that play a crucial role in regulating DNA supercoiling which affects fundamental biological processes involving DNA. In this review, we summarize the current understanding of regulation of supercoiling by DNA topoisomerases in the third domain of life, the Archaea, with a particular focus on three key model ...
Paul Villain, Tamara Basta
wiley +1 more source
Efficient Cleavage of pUC19 DNA by Tetraaminonaphthols
ChemistryOpen, Volume 14, Issue 2, February 2025.Anion receptor 4 was shown previously to cleave phosphodiesters by nucleophilic substitution. It also nicks plasmid DNA to some extent. We have now replaced the guanidines by ethylene diamine side chains. By this modification, the resulting tetraamine 13 becomes an effective DNA cleaver (R=H).
Catharina Kost +3 more
wiley +1 more source
Histones and histone variant families in prokaryotes
Nature CommunicationsHistones are important chromatin-organizing proteins in eukaryotes and archaea. They form superhelical structures around which DNA is wrapped. Recent studies have shown that some archaea and bacteria contain alternative histones that exhibit different ...
Samuel Schwab +8 more
doaj +1 more source
PLoS Genetics, 2012 To investigate the role of DNA topoisomerases in transcription, we have studied global gene expression in Saccharomyces cerevisiae cells deficient for topoisomerases I and II and performed single-gene analyses to support our findings.
Jakob Madsen Pedersen +9 more
doaj +1 more source
Salerno's model of DNA reanalysed: could solitons have biological significance?
, 2006 We investigate the sequence-dependent behaviour of localised excitations in a toy, nonlinear model of DNA base-pair opening originally proposed by Salerno. Specifically we ask whether ``breather'' solitons could play a role in the facilitated location of
A. Bolshoy +61 more
core +1 more source
Evidence for a Solenoid Phase of Supercoiled DNA
, 2018 In mechanical manipulation experiments, a single DNA molecule overwound at constant force undergoes a discontinuous drop in extension as it buckles and forms a superhelical loop (a plectoneme).
Dittmore, Andrew, Neuman, Keir C.
core +1 more source
Strand separation in negatively supercoiled DNA [PDF]
, 2018 .: We consider Benham's model for strand separation in negatively supercoiled circular DNA, and study denaturation as function of the linking difference density ...
Mazza, Christian
core
DNA denaturation bubbles: free-energy landscape and nucleation/closure rates
, 2015 The issue of the nucleation and slow closure mechanisms of non superhelical stress-induced denaturation bubbles in DNA is tackled using coarse-grained MetaDynamics and Brownian simulations.
Destainville, Nicolas +2 more
core +1 more source