Results 251 to 260 of about 2,258,474 (352)

MiR‐513a promotes human erythroid differentiation by modulating c‐Jun

FEBS Open Bio, EarlyView.
During early human erythropoiesis, miR‐513a promoted erythroid differentiation in primary human CD34+ hematopoietic stem‐progenitor cells and human TF‐1 erythroleukemic cells by indirectly decreasing c‐Jun and phospho‐c‐Jun expression, which are associated with increased GATA1 expression.
MinJung Kim, Brittany Taylor, Shannon Bolten, Christian L. Eberly, Mahliya Abdurahman, T. Michael Creed, Acong Yang, Taylor L. Hatchet, Tristan Dyson, Shuo Gu, Curt I. Civin, Tami J. Kingsbury   +11 more
wiley   +1 more source

PLM-DBPs: enhancing plant DNA-binding protein prediction by integrating sequence-based and structure-aware protein language models. [PDF]

Brief Bioinform
Pokharel S, Barasa K, Pratyush P, Kc DB.
europepmc   +1 more source

Digital twins to accelerate target identification and drug development for immune‐mediated disorders

FEBS Open Bio, EarlyView.
Digital twins integrate patient‐derived molecular and clinical data into personalised computational models that simulate disease mechanisms. They enable rapid identification and validation of therapeutic targets, prediction of drug responses, and prioritisation of candidate interventions.
Anna Niarakis, Philippe Moingeon
wiley   +1 more source

Tar DNA binding protein 43, a proteinopathy with preference for olfactory structures in COVID-19 subjects. [PDF]

J Alzheimers Dis Rep
Libard S, Alafuzoff I.
europepmc   +1 more source

Intein-based fluorescence labeling of the DNA binding domain of ultraspiracle protein

, 2006
Sz. Pakula, Marek Orłowski, Andrzej Ożyhar, Piotr Dobryszycki   +3 more
openalex   +1 more source

In vivo expression of a single viral DNA-binding protein generates systemic lupus erythematosus-related autoimmunity to double-stranded DNA and histones.

, 1995
Ugo Moens, Ole Morten Seternes, Ariann Hey, Yngve Silsand, Terje Traavik, Bjarne Johansen, OP Rekvig   +6 more
openalex   +1 more source

Rapid screening of staphylokinase protein variants using an unpurified cell‐free expression system

FEBS Open Bio, EarlyView.
An unpurified cell‐free protein synthesis (CFPS) platform enables rapid functional screening of staphylokinase variants. Direct plasminogen‐activation assays performed in microplate format provide real‐time activity readouts, allowing rapid identification and ranking of variants with improved or reduced fibrinolytic activity without protein ...
Maria Tomková, Veronika Hovanová, Jiri Damborsky, Erik Sedlák   +3 more
wiley   +1 more source

Evolutionarily divergent DUF4465 domains have a common vitamin B12‐binding function

FEBS Open Bio, EarlyView.
We show that DUF4465 family proteins, widespread across bacteria from gut microbiomes, hydrothermal vents, and soil, share a common vitamin B12‐binding function. These augmented β‐jellyroll proteins bind vitamin B12 via extended loops. Our findings establish sequence‐diverse DUF4465 proteins as a widespread class of B12‐binding proteins, highlighting ...
Charlea Clarke, Michal Banasik, Rokas Juodeikis, Martin J. Warren, Richard W. Pickersgill   +4 more
wiley   +1 more source

Molecular Sexing in Owls (Aves, Strigiformes) and the Unique Genetic Structure of the Chromodomain Helicase DNA-Binding Protein 1 (CHD1) Gene on Chromosome W. [PDF]

Genes (Basel)
Esaki M, Momohara K, Haga A, Narahashi M, Aung MM, Tokorozaki K, Haraguchi Y, Okuya K, Nishiumi I, Onuma M, Ozawa M.   +10 more
europepmc   +1 more source

Characterization of a DNA binding protein of bacteriophage PRD1 involved in DNA replication

, 1990
Tiina Pakula, Javier Caldentey, Manuel Serrano, Crisanto Gutiérrez, José M. Hermoso, Margarita Salas, Dennis H. Bamford   +6 more
openalex   +2 more sources