Results 191 to 200 of about 1,985,752 (333)

Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin

Molecular Oncology, EarlyView.
The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla, Jan Kosla, Magdalena Prechova, Lukas Frick, Patricia Bortel, Yasmin Borutzki, Andrea Bileck, Christopher Gerner, Samuel M. Meier‐Menches, Selma Osmanagic‐Myers, Martin Gregor   +10 more
wiley   +1 more source

Multiple RNA- and DNA-binding proteins exhibit direct transfer of polynucleotides with implications for target-site search. [PDF]

Proc Natl Acad Sci U S A, 2023
Hemphill WO, Voong CK, Fenske R, Goodrich JA, Cech TR.   +4 more
europepmc   +1 more source

Cyclic AMP Responsive Element- and Activator Protein 1 DNA-Binding Activities in Epilepsy Model Mice

, 1999
Kumiko Ishige, Yoshihisa Ito, Hideomi Fukuda   +2 more
openalex   +2 more sources

Therapeutic strategies for MMAE‐resistant bladder cancer through DPP4 inhibition

Molecular Oncology, EarlyView.
We established monomethyl auristatin E (MMAE)‐resistant bladder cancer (BC) cell lines by exposure to progressively increasing concentrations of MMAE in vitro. RNA sequencing showed DPP4 expression was increased in MMAE‐resistant BC cells. Both si‐DPP4 and the DPP4 inhibitor sitagliptin suppressed the viability of MMAE‐resistant BC cells.
Gang Li, Shuichi Tatarano, Hirofumi Yoshino, Saeki Saito, Mitsuhiko Tominaga, Junya Arima, Ikumi Fukuda, Takashi Sakaguchi, Ryosuke Matsushita, Yasutoshi Yamada, Hideki Enokida   +10 more
wiley   +1 more source

Base-resolution UV footprinting by sequencing reveals distinctive damage signatures for DNA-binding proteins. [PDF]

Nat Commun, 2023
Elliott K, Singh VK, Boström M, Larsson E.   +3 more
europepmc   +1 more source

Genomewide and biochemical analyses of DNA-binding activity of Cdc6/Orc1 and Mcm proteins in Pyrococcus sp. [PDF]

, 2007
Fujihiko Matsunaga, Annie Glatigny, Marie-Hélène Mucchielli-Giorgi, Nicolas Agier, Hervé Delacroix, Laëtitia Marisa, Patrice Durosay, Yoshizumi Ishino, Lawrence P. Aggerbeck, Patrick Forterre   +9 more
openalex   +1 more source

Recurrent cancer‐associated ERBB4 mutations are transforming and confer resistance to targeted therapies

Molecular Oncology, EarlyView.
We show that the majority of the 18 analyzed recurrent cancer‐associated ERBB4 mutations are transforming. The most potent mutations are activating, co‐operate with other ERBB receptors, and are sensitive to pan‐ERBB inhibitors. Activating ERBB4 mutations also promote therapy resistance in EGFR‐mutant lung cancer.
Veera K. Ojala, Sini Ahonen, Sara Peltola, Aura Tuohisto‐Kokko, Olaya Esparta, Peppi Suominen, Anne Jokilammi, Iman Farahani, Deepankar Chakroborty, Nikol Dibus, Steffen Boettcher, Tomi T. Airenne, Mark S. Johnson, Lisa D. Eli, Klaus Elenius, Kari J. Kurppa   +15 more
wiley   +1 more source

TransBind allows precise detection of DNA-binding proteins and residues using language models and deep learning. [PDF]

Commun Biol
Tahmid MT, Hasan AKMM, Bayzid MS.
europepmc   +1 more source

Hybrid_DBP: Prediction of DNA-binding proteins using hybrid features and convolutional neural networks. [PDF]

Front Pharmacol, 2022
Yu S, Peng D, Zhu W, Liao B, Wang P, Yang D, Wu F.   +6 more
europepmc   +1 more source

DNA-Binding Protein Ikaros [PDF]

, 2020
openaire   +1 more source