Results 41 to 50 of about 1,985,752 (333)

Preferential binding of hot spot mutant p53 proteins to supercoiled DNA in vitro and in cells. [PDF]

PLoS ONE, 2013
Hot spot mutant p53 (mutp53) proteins exert oncogenic gain-of-function activities. Binding of mutp53 to DNA is assumed to be involved in mutp53-mediated repression or activation of several mutp53 target genes.
Marie Brázdová, Lucie Navrátilová, Vlastimil Tichý, Kateřina Němcová, Matej Lexa, Roman Hrstka, Petr Pečinka, Matej Adámik, Borivoj Vojtesek, Emil Paleček, Wolfgang Deppert, Miroslav Fojta   +11 more
doaj   +1 more source

Urea Denaturation, Zinc Binding, and DNA Binding Assays of Mutant p53 DNA-binding Domains and Full-length Proteins

Bio-Protocol, 2021
In the cell, the thermodynamic stability of a protein – and hence its biological activity – can change dramatically as a result of perturbations in its amino acid sequence and the concentration of stabilizing ligands.
Jeung- Ha, Xin Yu, Darren Carpizo, Stewart Loh   +3 more
doaj   +1 more source

Interaction of the 89K murine cytomegalovirus immediate-early protein with core histones [PDF]

, 1988
The conditions that permit the interaction of immediate-early proteins of murine cytornegalovirus (MCMV) with DNA were studied. Chromatography of extracts from infected cells on MCMV DNA cellulose and calf thymus DNA cellulose showed that pp89, the ...
Alberts, Bookout, Ebeling, Einck, Everett, Faber, Freeman, Green, Günther M. Keil, Hay, Hermiston, Isenberg, Kedes, Keil, Keil, Keil, Keil, Konrad Munch, Koszinowski, Koszinowski, Koszinowski, Kristie, Kristie, Martin Messerle, O'Hare, Ohlenbusch, Purifoy, Reddehase, Rigby, Stein, Tevethia, Ulrich H. Koszinowski, Weissbach   +32 more
core   +1 more source

Pasteurellaceae ComE1 proteins combine the properties of fibronectin adhesins and DNA binding competence proteins.

PLoS ONE, 2008
A novel fibronectin-binding protein from Pasteurella multocida (PM1665) that binds to the fibronectin type III(9-10) modules via two helix-hairpin-helix motifs has recently been described [1].
Lisa M Mullen, Janine T Bossé, Sean P Nair, John M Ward, Andrew N Rycroft, Giles Robertson, Paul R Langford, Brian Henderson   +7 more
doaj   +1 more source

Comparison of histone-like HU protein DNA-binding properties and HU/IHF protein sequence alignment. [PDF]

PLoS ONE, 2017
The structure and function of bacterial nucleoid are controlled by histone-like proteins of HU/IHF family, omnipresent in bacteria and also founding archaea and some eukaryotes.HU protein binds dsDNA without sequence specificity and avidly binds DNA ...
Dmitri Kamashev, Yulia Agapova, Sergey Rastorguev, Anna A Talyzina, Konstantin M Boyko, Dmitry A Korzhenevskiy, Anna Vlaskina, Raif Vasilov, Vladimir I Timofeev, Tatiana V Rakitina   +9 more
doaj   +1 more source

Structural insights into the autoregulation and cooperativity of the human transcription factor Ets-2 [PDF]

, 2015
Ets-2, like its closely related homologue Ets-1, is a member of the Ets family of DNA binding transcription factors. Both proteins are subject to multiple levels of regulation of their DNA binding and transactivation properties.
Adams, Babayeva, Babayeva, Baillat, Baillat, Christopher D.O. Cooper, Cowley, Degnan, Desjardins, Emsley, Garvie, Goetz, Guen, Hagman, Hazel Aitkenhead, Hollenhorst, Jonsen, Joseph A Newman, Kabsch, Lamber, Lee, Lee, Lim, Opher Gileadi, Petersen, Pufall, Savitsky, Shaikhibrahim, Vagin, Venanzoni, Wang, Wang, Wasylyk, Wei   +33 more
core   +1 more source

DNA-binding activity of papillomavirus proteins [PDF]

Journal of Virology, 1987
We demonstrate DNA binding by papillomavirus (PV) open reading frame (ORF) proteins that correspond to the early transforming and trans-activating (E6 and E2) and late structural regions (L2 and L1) from bovine PV type 1 and human PV types 6b and 16.
R G, Mallon, D, Wojciechowicz, V, Defendi   +2 more
openaire   +2 more sources

Gadd45a is an RNA binding protein and is localized in nuclear speckles. [PDF]

PLoS ONE, 2011
The Gadd45 proteins play important roles in growth control, maintenance of genomic stability, DNA repair, and apoptosis. Recently, Gadd45 proteins have also been implicated in epigenetic gene regulation by promoting active DNA demethylation.
Yuliya A Sytnikova, Andriy V Kubarenko, Andrea Schäfer, Alexander N R Weber, Christof Niehrs   +4 more
doaj   +1 more source

Calling cards for DNA-binding proteins [PDF]

Genome Research, 2007
Identifying genomic targets of transcription factors is fundamental for understanding transcriptional regulatory networks. Current technology enables identification of all targets of a single transcription factor, but there is no realistic way to achieve the converse: identification of all proteins that bind to a promoter of interest. We have developed
Wang, Haoyi, Johnston, Mark, Mitra, Robi David   +2 more
openaire   +3 more sources

PredPSD: A Gradient Tree Boosting Approach for Single-Stranded and Double-Stranded DNA Binding Protein Prediction

Molecules, 2019
Interactions between proteins and DNAs play essential roles in many biological processes. DNA binding proteins can be classified into two categories. Double-stranded DNA-binding proteins (DSBs) bind to double-stranded DNA and are involved in a series of ...
Changgeng Tan, Tong Wang, Wenyi Yang, Lei Deng   +3 more
doaj   +1 more source