DNA-directed DNA Polymerase and Strand Displacement Activity of the Reverse Transcriptase Encoded by the R2 Retrotransposon [PDF]
Journal of Molecular Biology, 2007 R2 elements are non-long terminal repeat (non-LTR) retrotransposons with a single open reading-frame encoding reverse transcriptase, DNA endonuclease and nucleic acid-binding domains. The elements are specialized for insertion into the 28 S rRNA genes of many animal phyla.
Anna Kurzyńska‐Kokorniak +3 more
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Mode of inhibition of HIV-1 reverse transcriptase by polyacetylenetriol, a novel inhibitor of RNA- and DNA-directed DNA polymerases [PDF]
Biochemical Journal, 2002 Polyacetylenetriol (PAT), a natural marine product from the Mediterranean sea sponge Petrosia sp., was found to be a novel general potent inhibitor of DNA polymerases.
Shoshana Loya +3 more
semanticscholar +5 more sources
Polymerase Mu Is a DNA-Directed DNA/RNA Polymerase [PDF]
Molecular and Cellular Biology, 2003 DNA polymerases are defined as such because they use deoxynucleotides instead of ribonucleotides with high specificity. We show here that polymerase mu (pol μ), implicated in the nonhomologous end-joining pathway for repair of DNA double-strand breaks, incorporates both ribonucleotides and deoxynucleotides in a template-directed manner.
S. A. Nick McElhinny, D. Ramsden
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DNA-directed DNA Polymerase Activity in Oncogenic RNA Viruses
Nature, 1970 Besides having RNA-dependent DNA polymerase activity, oncogenic RNA viruses possess a DNA-directed DNA polymerase which is distinguished from previously described enzymes of this type in preferring double-stranded DNA as template and yielding a principally double-stranded product.
Sol Spiegelman +6 more
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The Pseudorabies Virus DNA Polymerase Accessory Subunit UL42 Directs Nuclear Transport of the Holoenzyme [PDF]
Frontiers in Microbiology, 2016 Pseudorabies virus (PRV) DNA replication occurs in the nuclei of infected cells and requires the viral DNA polymerase. The PRV DNA polymerase comprises a catalytic subunit, UL30, and an accessory subunit, UL42, that confers processivity to the enzyme ...
Yi-Ping eWang +6 more
doaj +3 more sources
On the Binding of Rifampicin to the DNA‐Directed RNA Polymerase from Escherichia coli [PDF]
European Journal of Biochemistry, 1973 The capacity of RNA polymerase to bind the antibiotic rifampicin is rather sensitive to conditions which lead to conformational changes in the enzyme. Repeated freezing and thawing in 1 M LiCl as well as treatment with guanidinium chloride destroys the binding affinity of the enzyme for the inhibitor. Similarly rifampicin does not associate with any of
Ute LILL, Guido R. Hartmann
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Data from DNA-Directed Polymerase Subunits Play a Vital Role in Human Telomeric Overhang Processing [PDF]
Molecular Cancer Research, 2023 Abstract Telomeres consist of TTAGGG repeats bound by the shelterin complex and end with a 3′ overhang. In humans, telomeres shorten at each cell division, unless telomerase (TERT) is expressed and able to add telomeric repeats.
Raffaella Diotti +3 more
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Animals, 2023 The genus Capripoxvirus belongs to the Poxviridae family. The sheeppox, goatpox, and lumpy skin disease viruses are three species of this genus with 96% identity in their genomes.
Ghulam Mustafa +6 more
doaj +3 more sources
Normal human placentas contain RNA-directed DNA polymerase activity like that in viruses. [PDF]
Proceedings of the National Academy of Sciences of the United States of America, 1978 Extracts from over 100 normal human placentas have been examined for RNA-directed DNA polymerase (DNA nucleotidyltransferase, EC 2.7.7.7) activity. More than 80% of these placentas contained this enzyme activity, which banded at a density of 1.15-1.17 g ...
Jay A. Nelson, J A Leong, Jay A. Levy
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DNA-directed DNA Polymerase [PDF]
Definitions, 2020 D. Schomburg, Dörte Stephan
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