Results 11 to 20 of about 666,524 (370)

The Pseudorabies Virus DNA Polymerase Accessory Subunit UL42 Directs Nuclear Transport of the Holoenzyme [PDF]

open access: yesFrontiers in Microbiology, 2016
Pseudorabies virus (PRV) DNA replication occurs in the nuclei of infected cells and requires the viral DNA polymerase. The PRV DNA polymerase comprises a catalytic subunit, UL30, and an accessory subunit, UL42, that confers processivity to the enzyme ...
Yi-Ping eWang   +6 more
doaj   +3 more sources

Semi-rational evolution of a recombinant DNA polymerase for modified nucleotide incorporation efficiency. [PDF]

open access: yesPLoS ONE
Engineering improved B-family DNA polymerases to catalyze 3'-O-modified nucleotide reversible terminators is limited by an insufficient understanding of the structural determinants that define polymerization efficiency.
Lili Zhai   +10 more
doaj   +2 more sources

DNA-directed termination of RNA polymerase II transcription [PDF]

open access: yesMolecular Cell, 2023
RNA polymerase II (RNAPII) transcription involves initiation from a promoter, transcriptional elongation through the gene, and termination in the terminator region. In bacteria, terminators often contain specific DNA elements provoking polymerase dissociation, but RNAPII transcription termination is thought to be driven entirely by protein co-factors ...
Zhong Han   +7 more
openaire   +3 more sources

Visualizing DNA polymerase ι catalyze Hoogsteen-directed DNA synthesis. [PDF]

open access: goldNat Commun
Frevert Z   +6 more
europepmc   +2 more sources

Human p53 interacts with the elongating RNAPII complex and is required for the release of actinomycin D induced transcription blockage [PDF]

open access: yes, 2017
The p53 tumour suppressor regulates the transcription initiation of selected genes by binding to specific DNA sequences at their promoters. Here we report a novel role of p53 in transcription elongation in human cells.
Boros, I.M. (Imre M.)   +7 more
core   +11 more sources

Polymerase IV occupancy at RNA-directed DNA methylation sites requires SHH1

open access: greenNature, 2013
Julie A. Law   +8 more
openalex   +3 more sources

Single-molecule view of coordination in a multi-functional DNA polymerase

open access: yeseLife, 2021
Replication and repair of genomic DNA requires the actions of multiple enzymatic functions that must be coordinated in order to ensure efficient and accurate product formation.
Raymond F Pauszek III   +3 more
doaj   +1 more source

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