Results 11 to 20 of about 416,069 (337)

DNA-Directed RNA Polymerase II Subunit RPB1 [PDF]

, 2020
National Cancer Institute
openalex   +2 more sources

Polymerase Mu Is a DNA-Directed DNA/RNA Polymerase [PDF]

Molecular and Cellular Biology, 2020
DNA polymerases are defined as such because they use deoxynucleotides instead of ribonucleotides with high specificity. We show here that polymerase mu (pol μ), implicated in the nonhomologous end-joining pathway for repair of DNA double-strand breaks, incorporates both ribonucleotides and deoxynucleotides in a template-directed manner.
S. A. Nick McElhinny, D. A. Ramsden
openalex   +3 more sources

DNA-directed termination of RNA polymerase II transcription [PDF]

Molecular Cell, 2023
RNA polymerase II (RNAPII) transcription involves initiation from a promoter, transcriptional elongation through the gene, and termination in the terminator region. In bacteria, terminators often contain specific DNA elements provoking polymerase dissociation, but RNAPII transcription termination is thought to be driven entirely by protein co-factors ...
Zhong Han, George A. Moore, Richard Mitter, David Lopez Martinez, Li Wan, A. Barbara Dirac Svejstrup, David S. Rueda, Jesper Q. Svejstrup   +7 more
openaire   +3 more sources

Mode of inhibition of HIV reverse transcriptase by 2-hexaprenylhydroquinone, a novel general inhibitor of RNA-and DNA-directed DNA polymerases [PDF]

Biochemical Journal, 1997
A natural compound from the Red Sea sponge Ircinia sp., 2-hexaprenylhydroquinone (HPH), has been shown to be a general inhibitor of retroviral reverse transcriptases (from HIV-1, HIV-2 and murine leukaemia virus) as well as of cellular DNA polymerases (Escherichia coli DNA polymerase I, and DNA polymerases α and β).
Shoshana Loya, Amira Rudi, Yoel Kashman, Amnon Hizi   +3 more
openalex   +4 more sources

DNA-Directed RNA Polymerase I Subunit RPA34

, 2020
National Cancer Institute
openalex   +2 more sources

POLH (polymerase (DNA direct), eta) [PDF]

Atlas of Genetics and Cytogenetics in Oncology and Haematology, 2011
Review on POLH (polymerase (DNA direct), eta), with data on DNA, on the protein encoded, and where the gene is implicated.
A Stary, A Sarasin
openaire   +1 more source

DNA-directed DNA Polymerase Activity in Oncogenic RNA Viruses

Nature, 1970
Besides having RNA-dependent DNA polymerase activity, oncogenic RNA viruses possess a DNA-directed DNA polymerase which is distinguished from previously described enzymes of this type in preferring double-stranded DNA as template and yielding a principally double-stranded product.
S. Spiegelman, Arsène Burny, M.R. Das, J. Keydar, Jeffrey Schlom, Martin Trávníček, Kenneth F. Watson   +6 more
openalex   +4 more sources

The Nuclear Proteins TP73 and CUL4A Confer Resistance to Cytarabine by Induction of Translesion DNA Synthesis via Mono-ubiquitination of PCNA

HemaSphere, 2022
Resistance to cytarabine is a key problem in the treatment of acute myeloid leukemia (AML). To understand the molecular biology of resistance to cytarabine, a viability-based chemosensitizer screen was utilized. We screened synthetic lethal targets using
Miriam Rehberger, Jonas A. Schäfer, Anna-Maria Krampitz, Anne Catherine Bretz, Lukas Jost, Torsten Haferlach, Thorsten Stiewe, Andreas Neubauer   +7 more
doaj   +1 more source

The trans-activation domain of the sporulation response regulator Spo0A revealed by X-ray crystallography [PDF]

, 2000
Sporulation in Bacillus involves the induction of scores of genes in a temporally and spatially co-ordinated programme of cell development. Its initiation is under the control of an expanded two-component signal transduction system termed a phosphorelay.
Baldus J.M., Brown D.P., Buckner C.M., Buckner C.M., Busby S., Chung J.D., Cowtan K., Ferrari F.A., Fogh R.H., Green B.D., Grimsley J.K., Hatt J.K., Igarashi K., Ireton K., Kenney T.J., Kondo H., Kuldell N., Makino K., Martinez-Hackert E., Muchova K., Murshudov G.N., Olmedo G., Perego M., Satola S.W., Schyns G., Spiegelman G.B., Spiegelman G.B., Strauch M.A., Strauch M.A., Terwilliger T.C., Weir J., Wu H.-M., York K.   +32 more
core   +1 more source

Dual role of φ29 DNA polymerase Lys529 in stabilisation of the DNA priming-terminus and the terminal protein-priming residue at the polymerisation site.

PLoS ONE, 2013
Resolution of the crystallographic structure of φ29 DNA polymerase binary and ternary complexes showed that residue Lys529, located at the C-terminus of the palm subdomain, establishes contacts with the 3' terminal phosphodiester bond.
Alicia del Prado, José M Lázaro, Laurentino Villar, Margarita Salas, Miguel de Vega   +4 more
doaj   +1 more source