Results 11 to 20 of about 47,098 (282)

Structural dynamic investigation of the mutation-induced resistance mechanisms of Mycobacterium tuberculosis DNA-directed RNA polymerase against Rifampicin

Emerging resistant strains of Mycobacterium tuberculosis (Mtb), the causative agent of tuberculosis (TB) disease, continue to plague mankind and reduce the efficacies of antitubercular therapies that have been an effective defence against TB for decades.
Mokgerwa Zacharia Monama
openalex   +3 more sources

RNase-like domain in DNA-directed RNA polymerase II. [PDF]

Proceedings of the National Academy of Sciences, 1991
DNA-directed RNA polymerase is responsible for gene expression. Despite its importance, many details of its function and higher-order structure still remain unknown. We report here a local sequence similarity between the second largest subunit of RNA polymerase II and bacterial RNases Ba (barnase), Bi, and St. The most remarkable similarity is that the
Mitiko Go, Tsuyoshi Shirai
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In Silico Analysis of Honey Bee Peptides as Potential Inhibitors of Capripoxvirus DNA-Directed RNA Polymerase

Animals, 2023
The genus Capripoxvirus belongs to the Poxviridae family. The sheeppox, goatpox, and lumpy skin disease viruses are three species of this genus with 96% identity in their genomes. These are financially devastating viral infections among cattle, which cause a reduction in animal products and lead to a loss in livestock industries.
Ghulam Mustafa, Hafiza Salaha Mahrosh, Mahwish Salman, Muhammad Ali, Rawaba Arif, Sibtain Ahmed, Hossam Ebaid   +6 more
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Investigation of Multi-Subunit Mycobacterium tuberculosis DNA-Directed RNA Polymerase and Its Rifampicin Resistant Mutants

International Journal of Molecular Sciences, 2023
Emerging Mycobacterium tuberculosis (Mtb) resistant strains have continued to limit the efficacies of existing antitubercular therapies. More specifically, mutations in the RNA replicative machinery of Mtb, RNA polymerase (RNAP), have been widely linked to rifampicin (RIF) resistance, which has led to therapeutic failures in many clinical cases ...
Mokgerwa Zacharia Monama, Fisayo Olotu, Özlem Tastan Bishop   +2 more
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Kinetic analysis of an efficient DNA-dependent TNA polymerase. [PDF]

, 2005
alpha-l-Threofuranosyl nucleoside triphosphates (tNTPs) are tetrafuranose nucleoside derivatives and potential progenitors of present-day beta-d-2'-deoxyribofuranosyl nucleoside triphosphates (dNTPs).
Chaput, John C, Horhota, Allen, Ichida, Justin K, McLaughlin, Larry W, Szostak, Jack W, Yu, Biao, Zou, Keyong   +6 more
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Isolation and physical properties of the DNA‐directed RNA polymerase from Thermus thermophilus HB8 [PDF]

European Journal of Biochemistry, 1990
The DNA‐directed RNA polymerase from the extremely thermophilic eubacterium Thermus thermophilus HB8 was purified employing a new and rapid method. The subunit pattern of the enzyme, analyzed by SDS gel electrophoresis, was interpreted as: 140 kDa and 170 kDa for β and β′, 40 kDa for α and 92 kDa for ó.
Stephan Wnendt, Roland K. Hartmann, Norbert Ulbrich, Volker A. Erdmann   +3 more
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Structure and Function of a Mycobacterial NHEJ DNA Repair Polymerase [PDF]

, 2006
Non homologous end-joining (NHEJ)-mediated repair of DNA double-strand breaks in prokaryotes requires Ku and a specific multidomain DNA ligase (LigD).
Aidan J. Doherty, Angel J. Picher, Arezi, Augustin, Bowater, Chen, Chen, Critchlow, Daley, Darren Thompson, DeFazio, Della, Dominguez, Emsley, Garcia-Diaz, Gavin C. Fox, Gong, Gong, Ito, Iyer, Jones, Krejci, La Fortelle, Lao-Sirieix, Lao-Sirieix, Lipps, Luis Blanco, Ma, Ma, Mahajan, Matsumoto, McCoy, Murshudov, Nick McElhinney, Nick McElhinny, Nick McElhinny, Nigel C. Brissett, Paula Andrade, Paull, Picher, Pitcher, Pitcher, Potterton, Potterton, Powell, Prasad, Ramsden, Raquel Juarez, Robert S. Pitcher, Ruiz, Rydberg, Singhal, Steitz, Tseng, Weller, Wilson, Winn, Wu, Zhang, Zhu   +59 more
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Antibodies to the DNA-directed RNA polymerase II subunit RPB1 occur with highest frequency in centenarians [PDF]

Immunity & Ageing, 2016
Recently, phage display technology has made it possible to define the circulating repertoire of humoral immunity. This study was designed to define the circulating antibodies specific to centenarians.We used a phage-displayed combinatorial peptide library to screen for peptides (YSATLRY and YSPTLFY) that preferentially react with the IgG fraction of ...
Han, Jungwon, Park, So-Hyun, Kim, Dong-Jo, Kim, Hyori, Choi, Yoon-Ho, Lee, Jong-Hyuk, Park, Sang Chul, Chung, Junho   +7 more
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RNA-directed DNA methylation involves co-transcriptional small-RNA-guided slicing of polymerase V transcripts in Arabidopsis. [PDF]

, 2018
Small RNAs regulate chromatin modifications such as DNA methylation and gene silencing across eukaryotic genomes. In plants, RNA-directed DNA methylation (RdDM) requires 24-nucleotide small interfering RNAs (siRNAs) that bind to ARGONAUTE 4 (AGO4) and ...
Chory, Joanne, Duttke, Sascha H, Feng, Suhua, Gallego-Bartolome, Javier, Groth, Martin, Hetzel, Jonathan, Jacobsen, Steven E, Kuo, Hsuan Yu, Liu, Wanlu, Wang, Zonghua, Zhai, Jixian, Zhong, Zhenhui   +11 more
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DNA-directed DNA Polymerase Activity in Oncogenic RNA Viruses

Nature, 1970
Besides having RNA-dependent DNA polymerase activity, oncogenic RNA viruses possess a DNA-directed DNA polymerase which is distinguished from previously described enzymes of this type in preferring double-stranded DNA as template and yielding a principally double-stranded product.
Spiegelman, S., Burny, Arsène, Das, M R, Keydar, J., Schlom, J., Travnicek, M., Watson, Kenneth M.   +6 more
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