Results 21 to 30 of about 98,603 (254)

Inhibition of Ebola Virus by Anti-Ebola miRNAs in silico

Journal of Infection in Developing Countries, 2016
Introduction: MicroRNAs (miRNAs) are small, noncoding RNA molecules that regulate transcriptional and posttranscriptional gene regulation of the organisms. miRNA provides immune defense when the body is faced with challenges intracellular agents.
Zhabiz Golkar, Roshan Battaria, Donald G Pace, Omar Bagasra   +3 more
doaj   +1 more source

Promoter opening by sigma(54) and sigma(70) RNA polymerases: sigma factor-directed alterations in the mechanism and tightness of control.

Genes & Development, 2000
Transcription control at the melting step is not yet understood. Here, band shift, cross-linking, and transcription experiments on diverse DNA probes were used with two bacterial RNA polymerase holoenzymes that differ in how they regulate melting.
Yuli Guo, C. M. Lew, J. Gralla
semanticscholar   +1 more source

Evolution of Complex RNA Polymerases: The Complete Archaeal RNA Polymerase Structure

PLoS Biology, 2009
The archaeal RNA polymerase (RNAP) shares structural similarities with eukaryotic RNAP II but requires a reduced subset of general transcription factors for promoter-dependent initiation.
Y. Korkhin, U. Unligil, O. Littlefield, P. J. Nelson, D. Stuart, P. Sigler, S. Bell, N. Abrescia   +7 more
semanticscholar   +1 more source

Ancient and novel small RNA pathways compensate for the loss of piRNAs in multiple independent nematode lineages.

PLoS Biology, 2015
Small RNA pathways act at the front line of defence against transposable elements across the Eukaryota. In animals, Piwi interacting small RNAs (piRNAs) are a crucial arm of this defence.
Peter Sarkies, Murray E Selkirk, John T Jones, Vivian Blok, Thomas Boothby, Bob Goldstein, Ben Hanelt, Alex Ardila-Garcia, Naomi M Fast, Phillip M Schiffer, Christopher Kraus, Mark J Taylor, Georgios Koutsovoulos, Mark L Blaxter, Eric A Miska   +14 more
doaj   +1 more source

Atypical DNA methylation of genes encoding cysteine-rich peptides in Arabidopsis thaliana

BMC Plant Biology, 2012
Background In plants, transposons and non-protein-coding repeats are epigenetically silenced by CG and non-CG methylation. This pattern of methylation is mediated in part by small RNAs and two specialized RNA polymerases, termed Pol IV and Pol V, in a ...
You Wanhui, Tyczewska Agata, Spencer Matthew, Daxinger Lucia, Schmid Marc W, Grossniklaus Ueli, Simon Stacey A, Meyers Blake C, Matzke Antonius JM, Matzke Marjori   +9 more
doaj   +1 more source

Structure and mechanism of the plant RNA polymerase V

Science, 2023
In addition to the conserved RNA polymerases I to III (Pols I to III) in eukaryotes, two atypical polymerases, Pols IV and V, specifically produce noncoding RNA in the RNA-directed DNA methylation pathway in plants.
Guohui Xie, Xuan Du, Hongmiao Hu, Sisi Li, Xiaofeng Cao, S. Jacobsen, Jiamu Du   +6 more
semanticscholar   +1 more source

Structure and RNA template requirements of Arabidopsis RNA-DEPENDENT RNA POLYMERASE 2

Proceedings of the National Academy of Sciences of the United States of America, 2021
Significance RDR2 is critical for siRNA-directed DNA methylation in Arabidopsis, functioning in physical association with DNA-dependent Pol IV to synthesize the second strands of double-stranded siRNA precursors.
Akihito Fukudome, Jasleen Singh, Vibhor Mishra, E. Reddem, Francisco Martínez-Márquez, S. Wenzel, Rui Yan, M. Shiozaki, Zhiheng Yu, J. Wang, Y. Takagi, C. Pikaard   +11 more
semanticscholar   +1 more source

Distinct transcriptional responses of RNA polymerases I, II and III to aptamers that bind TBP

Nucleic Acids Research, 2005
The TATA-binding protein (TBP) is a general factor that is involved in transcription by all three types of nuclear RNA polymerase. To delineate the roles played by the DNA-binding surface of TBP in these transcription reactions, we used a set of RNA ...
Xiaochun Fan, Hua Shi, J. Lis
semanticscholar   +1 more source

Crosstalk between the ribosome quality control‐associated E3 ubiquitin ligases LTN1 and RNF10

FEBS Letters, EarlyView.
Loss of the E3 ligase LTN1, the ubiquitin‐like modifier UFM1, or the deubiquitinating enzyme UFSP2 disrupts endoplasmic reticulum–ribosome quality control (ER‐RQC), a pathway that removes stalled ribosomes and faulty proteins. This disruption may trigger a compensatory response to ER‐RQC defects, including increased expression of the E3 ligase RNF10 ...
Yuxi Huang, Satoshi Hashimoto, Sota Ito, Chisato Kikuguchi, Miho Hoshi, Kiyoshi Yamaguchi, Yoichi Furukawa, Toru Suzuki, Toshifumi Inada   +8 more
wiley   +1 more source

Interplay between circadian and other transcription factors—Implications for cycling transcriptome reprogramming

FEBS Letters, EarlyView.
This perspective highlights emerging insights into how the circadian transcription factor CLOCK:BMAL1 regulates chromatin architecture, cooperates with other transcription factors, and coordinates enhancer dynamics. We propose an updated framework for how circadian transcription factors operate within dynamic and multifactorial chromatin landscapes ...
Xinyu Y. Nie, Jerome S. Menet
wiley   +1 more source