Results 11 to 20 of about 54,243 (194)

Increased Chlormethine-Induced DNA Double-Stranded Breaks in Malignant T Cells from Mycosis Fungoides Skin Lesions

JID Innovations, 2022
Mycosis fungoides (MF) is a type of cutaneous T-cell lymphoma. Chlormethine (CL) is recommended as first-line therapy for MF, with a major purpose to kill tumor cells through DNA alkylation.
Yun-Tsan Chang, Desislava Ignatova, Wolfram Hoetzenecker, Steve Pascolo, Christina Fassnacht, Emmanuella Guenova   +5 more
doaj   +1 more source

The SAGA Deubiquitination Module Promotes DNA Repair and Class Switch Recombination through ATM and DNAPK-Mediated γH2AX Formation

Cell Reports, 2016
Summary: Class switch recombination (CSR) requires activation-induced deaminase (AID) to instigate double-stranded DNA breaks at the immunoglobulin locus.
Shaliny Ramachandran, Dania Haddad, Conglei Li, Michael X. Le, Alexanda K. Ling, Clare C. So, Rajeev M. Nepal, Jennifer L. Gommerman, Kefei Yu, Troy Ketela, Jason Moffat, Alberto Martin   +11 more
doaj   +1 more source

Suboptimal extracellular pH values alter DNA damage response to induced double‐strand breaks

FEBS Open Bio, 2018
Conditions leading to unrepaired DNA double‐stranded breaks are potent inducers of genetic instability. Systemic conditions may lead to fluctuation of hydrogen ions in the cellular microenvironment, and we show that small variations in extracellular pH ...
Julien Massonneau, Camille Ouellet, Fabrice Lucien, Claire M. Dubois, Jessica Tyler, Guylain Boissonneault   +5 more
doaj   +1 more source

TUNEL Labeling to Detect Double-stranded DNA Breaks in Caenorhabditis elegans Gonads

Bio-Protocol, 2022
Analysis of DNA double strand breaks (DSBs) is important for understanding dyshomeostasis within the nucleus, impaired DNA repair mechanisms, and cell death. In the C.
Peter Kropp, Kyle Rhodehouse, Andy Golden   +2 more
doaj   +1 more source

Stitching up broken DNA ends by FANCA

Molecular & Cellular Oncology, 2018
RAD52 rejoins resected broken DNA ends by mediating single-strand annealing. Our recent work elucidates that FANCA, a Fanconi anemia protein, also directly repairs double-strand breaks (DSBs) by catalyzing annealing of single-stranded DNA.
Anna Palovcak, Wenjun Liu, Fenghua Yuan, Yanbin Zhang   +3 more
doaj   +1 more source

Oxidative stress-induced DNA damage and repair in human peripheral blood mononuclear cells: protective role of hemoglobin. [PDF]

PLoS ONE, 2013
BACKGROUND:DNA repair is a cellular defence mechanism responding to DNA damage caused in large part by oxidative stress. There is a controversy with regard to the effect of red blood cells on DNA damage and cellular response.
Anat Gafter-Gvili, Boris Zingerman, Benaya Rozen-Zvi, Yaacov Ori, Hefziba Green, Ido Lubin, Tsipora Malachi, Uzi Gafter, Michal Herman-Edelstein   +8 more
doaj   +1 more source

Inactivation of nuclear GSK3β by Ser389 phosphorylation promotes lymphocyte fitness during DNA double-strand break response

Nature Communications, 2016
Double stranded DNA breaks are generated during rearrangements of lymphocyte antigen receptors. Here the authors show that the DNA breaks induce phosphorylation of nuclear GSK3β at Ser389/Thr390, protecting the activated lymphocytes from necroptosis ...
Tina M. Thornton, Pilar Delgado, Liang Chen, Beatriz Salas, Dimitry Krementsov, Miriam Fernandez, Santiago Vernia, Roger J. Davis, Ruth Heimann, Cory Teuscher, Michael S. Krangel, Almudena R. Ramiro, Mercedes Rincón   +12 more
doaj   +1 more source

Structural basis for the inhibition of RecBCD by Gam and its synergistic antibacterial effect with quinolones

eLife, 2016
Our previous paper (Wilkinson et al, 2016) used high-resolution cryo-electron microscopy to solve the structure of the Escherichia coli RecBCD complex, which acts in both the repair of double-stranded DNA breaks and the degradation of bacteriophage DNA ...
Martin Wilkinson, Luca A Troman, Wan AK Wan Nur Ismah, Yuriy Chaban, Matthew B Avison, Mark S Dillingham, Dale B Wigley   +6 more
doaj   +1 more source

Reparative properties of human glioblastoma cells after single exposure to a wide range of X-ray doses

Frontiers in Oncology, 2022
Radiation therapy induces double-stranded DNA breaks in tumor cells, which leads to their death. A fraction of glioblastoma cells repair such breaks and reinitiate tumor growth.
Galina Pavlova, Galina Pavlova, Galina Pavlova, Alexandra Belyashova, Ekaterina Savchenko, Dmitri Panteleev, Dzhirgala Shamadykova, Anna Nikolaeva, Svetlana Pavlova, Alexander Revishchin, Denis Golbin, Alexander Potapov, Natalia Antipina, Andrey Golanov   +13 more
doaj   +1 more source

Reciprocal regulation of RIG-I and XRCC4 connects DNA repair with RIG-I immune signaling

Nature Communications, 2021
The RNA-sensing pathway has been associated with type I interferon (IFN) production induced by DNA damaging agents. Here the authors reveal that RIG-I, a cytosolic RNA sensor that recognizes RNA virus and initiates IFN signaling, is recruited to double ...
Guijie Guo, Ming Gao, Xiaochen Gao, Bibo Zhu, Jinzhou Huang, Xinyi Tu, Wootae Kim, Fei Zhao, Qin Zhou, Shouhai Zhu, Zheming Wu, Yuanliang Yan, Yong Zhang, Xiangyu Zeng, Qian Zhu, Ping Yin, Kuntian Luo, Jie Sun, Min Deng, Zhenkun Lou   +19 more
doaj   +1 more source