Results 51 to 60 of about 125,484 (288)

Copy number variations in urine cell-free DNA from bladder neoplasm patients

Molecular and Cellular Probes
Bladder cancer is a common malignancy, and its diagnosis is based on invasive procedures such as cystoscopy. Genetic aberrations play an important role in the development of many diseases, including bladder cancer.
Cuello Garcia Haider, Qichao Wang, Guangyue Wang, Yinfeng Wang, Yutong Fu, Zhoufan Zhang, Changling Cao, Fengcheng Xue, Haitao Liu, Qian Wang, Jie Zhou, Tingya Jiang, Jingyi Cao, Yang Zhou   +13 more
doaj   +1 more source

DNA copy number changes define spatial patterns of heterogeneity in colorectal cancer [PDF]

, 2017
Genetic heterogeneity between and within tumours is a major factor determining cancer progression and therapy response. Here we examined DNA sequence and DNA copy-number heterogeneity in colorectal cancer (CRC) by targeted high-depth sequencing of 100 ...
Mamlouk, Soulafa, Sers, Christine [u. v. m.], Heim, Daniel, Aust, Daniela, Oliveira, Cristiano, Melching, Friederike, Childs, Liam Harold   +6 more
core   +6 more sources

Circos plot of somatic mutations, copy number variations, transcriptome expression, and structural variations. [PDF]

, 2013
From inside to out, structural variations (purple and orange), copy number variations (gain in dark red, loss in dark blue, mRNA expression (up in gold, down in olive), differentially expressed microRNAs (up in red, down in green), DNA methylation with ...
Jihae Seo (279951), Sang Cheol Kim (137613), Pora Kim (6055), So-Jung Choi (279961), Jinseon Lee (279957), Sanghyuk Lee (6060), Namshin Kim (6056), Yeonhwa Jung (279955), Jiwoong Kim (279952), Wankyu Kim (279962), Sooyoung Cho (279948), Byungwook Lee (23910), Jaesang Kim (181982), Sangeun Kang (279959), Jinah Park (45976), Sujin Bae (279960), Jehwan Park (279950), Jungho Han (279958), Yeonjoo Jung (279947), Jin Ok Yang (216197), Jhingook Kim (225926), Seongjin Park (279953), Jong-Eun Lee (225501), Juhee Keum (279956), Chaehwa Seo (279949), Sujin Kim (225506), Insu Jang (279954), Kyoohyoung Rho (145991)   +27 more
core   +1 more source

Copy number variation of ribosomal DNA and Pokey transposons in natural populations of Daphnia [PDF]

Mobile DNA, 2012
Despite their ubiquity and high diversity in eukaryotic genomes, DNA transposons are rarely encountered in ribosomal DNA (rDNA). In contrast, R-elements, a diverse group of non-LTR retrotransposons, specifically target rDNA. Pokey is a DNA transposon that targets a specific rDNA site, but also occurs in many other genomic locations, unlike R-elements ...
Eagle Shannon HC, Crease Teresa J
openaire   +3 more sources

Transferrin receptor 1‐mediated iron uptake supports thermogenic activation in human cervical‐derived adipocytes

FEBS Letters, EarlyView.
In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai, Mizuki Seo, Gyath Karadsheh, Fachrur Rizal Mahendra, Máté Á Demény, Ferenc Győry, János András Mótyán, László Fésüs, Endre Kristóf, Rini Arianti   +9 more
wiley   +1 more source

DNA copy number profiling using single-cell sequencing. [PDF]

, 2018
Currently, there is a lack of software for detecting copy number variations and constructing copy number profile for the whole genome from single-cell DNA sequencing data, which are often of low coverage and high technical noises. Here we introduce a new
Wang, Xuefeng, Zhang, Nancy R, Chen, Hao
core   +1 more source

Nanopore sequencing from liquid biopsy: analysis of copy number variations from cell-free DNA of lung cancer patients [PDF]

, 2021
In the “precision oncology” era the characterization of tumor genetic features is a pivotal step in cancer patients’ management. Liquid biopsy approaches, such as analysis of cell-free DNA from plasma, represent a powerful and noninvasive strategy to ...
Conticello S. G., Munagala U., Martignano F., Magi A., Semeraro R., Petrini I., Del Re M., Mingrino A., Crucitta S.   +8 more
core   +1 more source

Sequential Model Selection-Based Segmentation to Detect DNA Copy Number Variation [PDF]

Biometrics, 2016
Summary Array-based CGH experiments are designed to detect genomic aberrations or regions of DNA copy-number variation that are associated with an outcome, typically a state of disease. Most of the existing statistical methods target on detecting DNA copy number variations in a single sample or array.
Hu, Jianhua, Zhang, Liwen, Wang, Huixia Judy   +2 more
openaire   +3 more sources

Epigenetic blind spots – the role of DNA methylation dynamics in stem cell‐based models of embryogenesis

FEBS Letters, EarlyView.
Embryo‐like structures (stembryos) are an innovative tool, but they are hindered by experimental variability and limited developmental potential. DNA methylation is crucial for mammalian development, but its status in stembryo models is poorly characterized.
Sara Canil, Anna Corrà, Annalisa Scapolatiello, Chengxiang Qiu, Gianluca Amadei   +4 more
wiley   +1 more source

The role of genomic Copy Number Variation (CNV) in osteoporosis [PDF]

, 2012
Copy number variation (CNV) is a relatively novel source of genetic variation, involving the duplication or deletion of segments of genomic DNA (gDNA) sequence, thereby changing the original number of DNA copies.
Connolly, Kate
core   +1 more source