Results 61 to 70 of about 288,493 (295)

Ethnic Differences in the Association Between SOD2 rs4880 and Hepatotoxicity in Pediatric Acute Lymphoblastic Leukemia: A Report From the REDIAL Consortium

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Treatment‐associated hepatotoxicity (TAH) is a common complication of pediatric acute lymphoblastic leukemia (ALL) treatment, but genetic risk factors remain poorly understood. We evaluated the SOD2 rs4880 variant in 544 children with ALL at Texas Children's Hospital. After adjusting for demographic and clinical covariates, the rs4880 C allele
Emily J. Mason, John P. Woodhouse, Joanna S. Yi, M. Monica Gramatges, Olga A. Taylor, Veronica A. Morales, Shalini Dhamodharan, Marley Roberts, Karen R. Rabin, Philip J. Lupo, Michael E. Scheurer, Van Huynh, Steven D. Mittelman, Etan Orgel, Austin L. Brown   +14 more
wiley   +1 more source

AthCNV: A Map of DNA Copy Number Variations in the Arabidopsis Genome [PDF]

The Plant Cell, 2020
Abstract Copy number variations (CNVs) greatly contribute to intraspecies genetic polymorphism and phenotypic diversity. Recent analyses of sequencing data for >1000 Arabidopsis (Arabidopsis thaliana) accessions focused on small variations and did not include CNVs.
Agnieszka Zmienko, Malgorzata Marszalek-Zenczak, Pawel Wojciechowski, Anna Samelak-Czajka, Magdalena Luczak, Piotr Kozlowski, Wojciech M. Karlowski, Marek Figlerowicz   +7 more
openaire   +2 more sources

A novel technique for measuring variations in DNA copy-number: competitive genomic polymerase chain reaction

BMC Genomics, 2007
Background Changes in genomic copy number occur in many human diseases including cancer. Characterization of these changes is important for both basic understanding and diagnosis of these diseases. Microarrays have recently become the standard technique
Nakagawara Akira, Kawamoto Shoko, Saito Sakae, Nakamura Yohko, Maekawa Kazunori, Iwao-Koizumi Kyoko, Kato Kikuya   +6 more
doaj   +1 more source

DNA rare copy number alterations in Reinke’s Edema

Brazilian Journal of Otorhinolaryngology, 2023
Introduction: Reinke’s Edema (RE) is a laryngeal lesion related to excessive tobacco smoking, voice overuse, and laryngopharyngeal reflux. Although the risk of malignancy has been considered low in literature, RE is classified among precancerous lesions.
Luis Eduardo Silva Móz, Regina Helena Garcia Martins, Rainer Marco Lopez Lapa, Rolando André Rios Villacis, Patricia Pintor dos Reis, Silvia Regina Rogatto   +5 more
doaj   +1 more source

Detection of copy number variations and their effects in Chinese bulls [PDF]

, 2014
BACKGROUND: Copy number variations (CNVs) are a main source of genomic structural variations underlying animal evolution and production traits. Here, with one pure-blooded Angus bull as reference, we describe a genome-wide analysis of CNVs based on ...
Chunlei Zhang, Chuzhao Lei, Congjun Li, Hong Chen, Jiajie Sun, Liangzhi Zhang, Mingjuan Yang, Shangang Jia, Xianyong Lan, Xin Zhao, Yang Zhou, Yao Xu, Yongzhen Huang   +12 more
core   +1 more source

Mapping the evolution of mitochondrial complex I through structural variation

FEBS Letters, EarlyView.
Respiratory complex I (CI) is crucial for bioenergetic metabolism in many prokaryotes and eukaryotes. It is composed of a conserved set of core subunits and additional accessory subunits that vary depending on the organism. Here, we categorize CI subunits from available structures to map the evolution of CI across eukaryotes. Respiratory complex I (CI)
Dong‐Woo Shin, Tingting Chen, James A. Letts   +2 more
wiley   +1 more source

Variations in ribosomal DNA copy numbers in a genome of Trichophyton interdigitale [PDF]

Mycoses, 2020
SummaryBackgroundRibosomal DNA (rDNA) reportedly has multiple copies in the fungal genome. The internal transcribed spacer (ITS) region in rDNA is useful for investigating relationships between close taxonomic relatives. Thus, ITS has been widely used as a target gene in medical mycology for the detection of pathogenic fungi and identification of ...
Tomoyuki Iwanaga, Kazushi Anzawa, Takashi Mochizuki   +2 more
openaire   +2 more sources

Mathematical analysis of copy number variation in a DNA sample using digital PCR on a nanofluidic device. [PDF]

PLoS ONE, 2008
Copy Number Variations (CNVs) of regions of the human genome have been associated with multiple diseases. We present an algorithm which is mathematically sound and computationally efficient to accurately analyze CNV in a DNA sample utilizing a ...
Simant Dube, Jian Qin, Ramesh Ramakrishnan   +2 more
doaj   +1 more source

Genomic variations associated with attenuation in Mycobacterium avium subsp paratuberculosis vaccine strains [PDF]

, 2013
BACKGROUND: Mycobacterium avium subspecies paratuberculosis (MAP) whole cell vaccines have been widely used tools in the control of Johne's disease in animals despite being unable to provide complete protection. Current vaccine strains derive from stocks
Bull, TJ, Greene, M, Linedale, R, McKendrick, IJ, Sales, J, Schock, A, Sharp, JM, Stevenson, K   +7 more
core   +1 more source

The newfound relationship between extrachromosomal DNAs and excised signal circles

FEBS Letters, EarlyView.
Extrachromosomal DNAs (ecDNAs) contribute to the progression of many human cancers. In addition, circular DNA by‐products of V(D)J recombination, excised signal circles (ESCs), have roles in cancer progression but have largely been overlooked. In this Review, we explore the roles of ecDNAs and ESCs in cancer development, and highlight why these ...
Dylan Casey, Zeqian Gao, Joan Boyes
wiley   +1 more source