Results 111 to 120 of about 95,440 (308)

Elevated 5hmC levels characterize DNA of the cerebellum in Parkinson’s disease

npj Parkinson's Disease, 2017
5-methylcytosine and the oxidation product 5-hydroxymethylcytosine are two prominent epigenetic variants of the cytosine base in nuclear DNA of mammalian brains.
Reinhard Stöger, Paula J. Scaife, Freya Shephard, Lisa Chakrabarti   +3 more
doaj   +1 more source

A multi-parametric flow cytometric assay to analyze DNA–protein interactions [PDF]

, 2012
Interactions between DNA and transcription factors (TFs) guide cellular function and development, yet the complexities of gene regulation are still far from being understood.
Ana Arbab, David K. Gifford, Er Rolfe, Hyunjii Cho, Joel M. Chick, John Peter Van Hoff, P. Alex, Richard I. Sherwood, Richard L. Maas, Shaun Mahony, Steven P. Gygi, Viveca W. S. Morris   +11 more
core   +2 more sources

Combinatorial expression of glial transcription factors induces Schwann cell‐specific gene expression in mouse embryonic fibroblasts

Developmental Dynamics, EarlyView.
Abstract Background Schwann cells provide peripheral nerve trophic support, myelinate axons, and assist in repair. However, Schwann cell repair capacity is limited by chronic injury, disease, and aging. Schwann cell reprogramming is a cellular conversion strategy that could provide a renewable cell supply to repair injured nerves.
Lauren Belfiore, Anjali Balakrishnan, Yacine Touahri, Dawn Zinyk, Humna Noman, Satoshi Okawa, Jeff Biernaskie, Carol Schuurmans   +7 more
wiley   +1 more source

Accurate estimation of 5-methylcytosine in mammalian mitochondrial DNA

Scientific Reports, 2018
Whilst 5-methylcytosine (5mC) is a major epigenetic mark in the nuclear DNA in mammals, whether or not mitochondrial DNA (mtDNA) receives 5mC modification remains controversial.
Shigeru Matsuda, Takehiro Yasukawa, Yuriko Sakaguchi, Kenji Ichiyanagi, Motoko Unoki, Kazuhito Gotoh, Kei Fukuda, Hiroyuki Sasaki, Tsutomu Suzuki, Dongchon Kang   +9 more
doaj   +1 more source

DNA methylation and cognitive functioning in healthy older adults [PDF]

, 2017
Long-term supplementation with folic acid may improve cognitive performance in older individuals. The relationship between folate status and cognitive performance might be mediated by changes in methylation capacity, as methylation reactions are ...
de Groot, Renate H. M., Durga, Jane, Jolles, Jelle, Kok, Frans J., Schiepers, Olga J. G., van Boxtel, Martin P. J., Verhoef, Petra   +6 more
core  

Effects of Particulate Matter on Genomic DNA Methylation Content and iNOS Promoter Methylation [PDF]

, 2011
Background: Altered patterns of gene expression mediate the effects of particulate matter (PM) on human health, but mechanisms through which PM modifies gene expression are largely undetermined.Objectives We aimed at identifying short- and long-term ...
Apostoli, Pietro, Baccarelli, Andrea, Bertazzi, Pier Alberto, Bollati, Valentina, Bonzini, Matteo, Cantone, Laura, Hou, Lifang, Marinelli, Barbara, Pegoraro, Valeria, Rizzo, Giovanna, Schwartz, Joel David, Tarantini, Letizia   +11 more
core   +1 more source

Codelivery of Genistein and miRNA-29b to A549 Cells Using Aptamer-Hybrid Nanoparticle Bioconjugates. [PDF]

, 2019
This study aimed to evaluate the anti-cancer effect of a combination therapy of miRNA-29b and genistein loaded in mucin-1 (MUC 1)-aptamer functionalized hybrid nanoparticles in non-small cell lung cancer (NSCLC) A549 cell line. Genistein-miRNA-29b-loaded
Sacko, Koita, Shoyele, Sunday A., Thangavel, Karthik   +2 more
core   +1 more source

Semi-quantitative proteomics of mammalian cells upon short-term exposure to nonionizing electromagnetic fields [PDF]

, 2017
The potential effects of non-ionizing electromagnetic fields (EMFs), such as those emitted by power-lines (in extremely low frequency range), mobile cellular systems and wireless networking devices (in radio frequency range) on human health have been ...
Bezstarosti, K. (Karel), Dekkers, D.H. (Dick), Demmers, J.A.A. (Jeroen), Eppink, B. (Berina), Kanaar, R. (Roland), Kuzniar, A. (Arnold), Laffeber, C., Lebbink, J.H.G. (Joyce), Woelders, H. (Henri), Zwamborn, A.P.M. (Adrianus)   +9 more
core   +1 more source

Beyond “you are what you eat”: Unlocking gut microbiota‐mediated biotransformation of dietary phytochemicals

iMetaOmics, EarlyView.
The “efficacy paradox” of phytochemicals, low bioavailability yet significant health benefits, is associated with gut microbiota, which biotransforms dietary precursors into bioactive metabolites, enabling systemic effects. Thus, health outcomes of diet depend not just on intake “the rainbow”, but on gut microbial metabolism, redefining “you are what ...
Peng Yang, Ren‐You Gan
wiley   +1 more source

In silico analysis of regulatory and structural motifs of the ovine HSP90AA1 gene [PDF]

, 2016
Gene promoters are essential regions of DNA where the transcriptional molecular machinery to produce RNA molecules is recruited. In this process, DNA epigenetic modifications can acquire a fundamental role in the regulation of gene expression.
Calvo Lacosta, Jorge Hugo, González, Carmen, Salces Ortiz, Judit, Serrano, Mª Magdalena   +3 more
core   +1 more source