Results 121 to 130 of about 739 (150)

DNA (cytosine-5)-methyltransferase 3B - [Isoform 1]

Targeted Protein Database, 2008
A DNMT3B (DNMT3B , DNA (cytos ine-5)methyltransferase 3B; Swiss-Prot accession number: Q9UBC3) gene deletion construct in which exons 16–19 were deleted was used to generate Dnmt3b-null ES cells and animals. The deleted region encodes the highly conserved PC (proline cysteine) and ENV (glutamic acid, asparagine, valine) motifs that are crucial for ...
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Impact of Cytosine 5-Halogens on the Interaction of DNA with Restriction Endonucleases and Methyltransferase

Chemical Research in Toxicology, 2006
Growing evidence from both prokaryotes and eukaryotes indicates that pyrimidine 5-methyl groups can have profound biological consequences that are mediated by the affinity of DNA-protein interactions. The presence of the 5-methyl group could potentially create a steric block preventing the binding of some proteins whereas the affinity of many other ...
Victoria, Valinluck, Winnie, Wu, Pingfang, Liu, Jonathan W, Neidigh, Lawrence C, Sowers   +4 more
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Regulation of Expression and Activity of DNA (Cytosine-5) Methyltransferases in Mammalian Cells

2011
Three active DNA (cytosine-5) methyltransferases (DNMTs) have been identified in mammalian cells, Dnmt1, Dnmt3a, and Dnmt3b. DNMT1 is primarily a maintenance methyltransferase, as it prefers to methylate hemimethylated DNA during DNA replication and in vitro. DNMT3A and DNMT3B are de novo methyltransferases and show similar activity on unmethylated and
Shannon R Morey, Kinney, Sriharsa, Pradhan   +1 more
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DNA (Cytosine-5) Methyltransferase Inhibitors: A Potential Therapeutic Agent for Schizophrenia

Molecular Pharmacology, 2007
In this issue of Molecular Pharmacology, Kundakovic et al. (p. 644) present compelling evidence suggesting that the promoters for reelin and GAD67 are coordinately regulated. The regulation occurs at the level of DNA (cytosine-5) methylation. Moreover, the authors present evidence suggesting that pharmacologic inhibition of DNA methyltransferase ...
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Biological Implications of the Mechanism of Action of Human DNA (Cytosine-5)methyltransferase

1994
Publisher Summary This chapter describes the enzymological boundaries of the phenomenon of human deoxyribonucleic acid (DNA) methylation, set by the specificity and mechanism of action of the human DNA methyltransferase(s). The formation of a tight, and presumably covalent, complex, between DNA, containing 5-azacytosine and DNA (cytosine-5 ...
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DNA (cytosine-5-)-methyltransferase

1996
Dietmar Schomburg, Dörte Stephan
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Recognition of structural perturbations in DNA by human DNA(cytosine-5)methyltransferase

Gene, 1988
D J, Baker, J L, Kan, S S, Smith
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DNA (cytosine-5-)-methyltransferase

2008
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Co-operation and communication between the human maintenance and de novo DNA (cytosine-5) methyltransferases

EMBO Journal, 2002
Gun-Do Kim, Sriharsa Pradhan
exaly  

DNA (cytosine-5)-methyltransferases in mouse cells and tissues. studies with a mechanism-based probe

Journal of Molecular Biology, 1997
Gregory Verdine, Jeffrey Yoder, Timothy Bestor   +2 more
exaly