Results 121 to 130 of about 94,067 (257)

Transgenic selection and underlying mechanisms in apicomplexan parasites

The FEBS Journal, EarlyView.
Transgenic selection markers have driven genetic engineering in apicomplexans, enabling precise, iterative experiments. This review discusses mechanistic details of drug selection markers, strategies for marker recycling, and practical considerations for several clinically relevant parasites.
Swaroop Peddiraju, Rakhee Lohia, Nishith Gupta   +2 more
wiley   +1 more source

Gene Editing for Haemophilia—The Next Frontier

Haemophilia, EarlyView.
ABSTRACT The recently approved haemophilia A and B gene therapies via adeno‐associated virus (AAV) showed a promising therapeutic response after a single injection, but there are still limitations, including the potential loss of transgene expression and restriction in adults.
Mirko Pinotti, Gregory A. Newby, Sundar Selvaraj, Steven W. Pipe   +3 more
wiley   +1 more source

Design, Synthesis, and Evaluation of a Novel Phenanthrene Derivative as a Potential DNA Intercalator. [PDF]

ACS Chem Biol
Bouz G, Quaglia G, Latterini L, Barta P, Jand'ourek O, Konečná K, Ősterreicher J, Naesens L, Persoons L, Storch J, Panov I.   +10 more
europepmc   +1 more source

Molecular Characterisation of Orf Virus in Goats From Eastern Türkiye. [PDF]

Vet Med Sci
This study provides the molecular characterisation of Orf virus (ORFV) strains circulating in Türkiye. Phylogenetic analysis of F1L, B2L, and VIR genes reveals high genetic similarity with Asian and global isolates, highlighting the importance of multi‐gene analysis in monitoring viral outbreaks and understanding disease origins.
Özbek R, Ilgın M, Can-Şahna K.
europepmc   +2 more sources

Transcriptomic and proteomic signatures underlying nymphal adaptation and foam production in the forage pest Mahanarva spectabilis

Insect Molecular Biology, EarlyView.
RNA‐seq and Batelli gland proteomics of fifth‐instar Mahanarva spectabilis nymphs reveal transcripts and proteins associated with xylem feeding, foam production and environmental interaction. Functional annotation identified genes involved in osmoregulation, detoxification, chemosensation and stress responses, while proteomic analysis confirmed ...
Monique da Silva Bonjour, Angelo José Rinaldi, Eulálio Gutemberg Dias dos Santos, Gabriely Teixeira Bhering Faria, Ana Márcia Escocard de Azevedo Manhães, Jorge Fernando Pereira, Alexander Machado Auad, Maria Goreti de Almeida Oliveira, Humberto Josué de Oliveira Ramos   +8 more
wiley   +1 more source

Hydropathy Landscapes of Histone-DNA Interactions in Chromatin Building Blocks. [PDF]

J Phys Chem B
Mandal R, Noel AC, Baur AM, Nangia S.
europepmc   +1 more source

DNA (cytosine-5-)-methyltransferase 3α ( DNMT3A ) [PDF]

Science-Business eXchange, 2014
openaire   +1 more source

Genome assembly of Elcysma westwoodi provides insights into host‐plant cyanogenic glucoside detoxification and chemical defence gene evolution

Insect Molecular Biology, EarlyView.
A chromosome‐level genome of Elcysma westwoodi was assembled. The genome encodes 272 detoxification‐related genes. A single‐copy bCAS was retained for cyanide detoxification. CYP405A and CYP332A were recruited into cyanogenic defence evolution. UGT33A retained a conserved GT‐B fold and catalytic domains.
Minyoung Choi, Murtaza Khan, Juil Kim
wiley   +1 more source

Peptide-directed folding of the elusive RNA i-motif. [PDF]

Chem Sci
Cox LB, Thordarson P, Rizzuto FJ.
europepmc   +1 more source

Cytosolic delivery of bacterial metabolites by riboflavin transporters promotes MR1 antigen presentation and MAIT cell recognition

Immunology &Cell Biology, EarlyView.
VitBAg antigen presentation is promoted through a cytosolic pathway that reaches ligand‐receptive MR1 to present to MAIT cells, like the riboflavin transport pathway. Riboflavin solute carrier transporters can promote this MR1 presentation, but they are not essential for this role, suggesting redundant pathways to uptake VitBAg.
Sebastian Cruz‐Gomez, Hui Jing Lim, Brunda Nijagal, Yuting Yang, Nicole Lau, Jeffrey YW Mak, David P Fairlie, Hayley Newton, Mariolina Salio, Jose A Villadangos, Hamish EG McWilliam   +10 more
wiley   +1 more source