Spaceborne and spaceborn: Physiological aspects of pregnancy and birth during interplanetary flight
Experimental Physiology, EarlyView.Abstract Crewed interplanetary return missions that are on the planning horizon will take years, more than enough time for initiation and completion of a pregnancy. Pregnancy is viewed as a sequence of processes – fertilization, blastocyst formation, implantation, gastrulation, placentation, organogenesis, gross morphogenesis, birth and neonatal ...
Arun V. Holden
wiley +1 more source
Computational and Systems Oncology, Volume 6, Issue 1, December 2026.ABSTRACT Resistance to chemotherapy, which is demonstrated in almost every patient with advanced‐stage lung cancer (ALC), underscores an urgent need to unravel the underlying molecular mechanisms and identify novel strategies to overcome drug resistance. In the present study, an attempt was made to identify epigenetic targets and modulators that can be
Okibur Rahman +2 more
wiley +1 more source
Advances in gene therapy for mitochondrial genetic disorders: current status and clinical implementation challenges. [PDF]
J Transl MedLyu L, Qie B, He Y, Chen F, Liu B.
europepmc +1 more source
International Journal of Cancer, Volume 158, Issue 7, Page 1821-1835, 1 April 2026.What's new? Most patients with ovarian cancer (OC) relapse after first‐line chemotherapy, and prognosis with second‐line treatment depends largely on the platinum‐free interval. However, reliable biomarkers to predict response to second‐line therapy remain lacking.
Muhammad Habiburrahman +7 more
wiley +1 more source
Mitochondrial Base Editing of the m.8993T>G Mutation Restores Bioenergetics and Neural Differentiation in Patient iPSCs. [PDF]
Genes (Basel)Yin L, Yin A, Jones M.
europepmc +1 more source
International Journal of Cancer, Volume 158, Issue 6, Page 1489-1497, 15 March 2026.What's new? Breast cancer results from a combination of genetic and environmental causes, and the cumulative effect of stressful life events may be a contributing factor. Here, the authors analyzed data from cohort and twin‐pair studies including 36 years of follow‐up to find out how stressful life events affect breast cancer risk. They found that even
Elissar Azzi +5 more
wiley +1 more source
Electronic and Optical Sensitivity of Aluminum-Doped Boron Phosphide Monolayers for DNA Base Detection: A First-Principles Study. [PDF]
ACS OmegaYe S, Yeh CH.
europepmc +1 more source
Prostaglandin D2 Synthase Controls Schwann Cells Metabolism and Peripheral Myelin Homeostasis
Glia, Volume 74, Issue 3, March 2026.Prostaglandin D2 Synthase (L‐PGDS) controls PPNS myelin lipids’ composition and Schwann cells energetic metabolism In the absence of L‐PGDS Schwann cells turn to acetate as the main energetic source. These metabolic changes result in ketone bodies production to preserve neuronal survival.
Amelia Trimarco +16 more
wiley +1 more source
Unnatural Amino Acid and Emerging Chemistry Approaches to Map RNA–Protein Interactions
Angewandte Chemie, Volume 138, Issue 6, 2 February 2026.This review highlights emerging chemistries for mapping RNA–protein interactions, including genetically encoded unnatural amino acids, novel photocrosslinkers, and non‐photoactivatable crosslinking systems. We compare their mechanisms, reactivity and applications, outlining how these next‐generation tools enable higher‐resolution, site‐specific ...
Eryn Lundrigan +3 more
wiley +2 more sources
Tuning i-motif folding and stability with acyclic phosphonate-linked (ZNA) cytidine residues. [PDF]
RSC AdvDerden M +8 more
europepmc +1 more source