Results 211 to 220 of about 94,067 (257)

Impact of influential data on screening epigenome-wide data. [PDF]

BMC Bioinformatics
Sultana S, Zhang H, Jiang Y, Abrar MNF, Arshad H, Xie L, Ray M.   +6 more
europepmc   +1 more source

The DNA (cytosine-5) methyltransferases [PDF]

Nucleic Acids Research, 1994
The m5C-MTases form a closely-knit family of enzymes in which common amino acid sequence motifs almost certainly translate into common structural and functional elements. These common elements are located predominantly in a single structural domain that performs the chemistry of the reaction.
Xiaodong Cheng, Saulius Klimasauskas, János Posfai   +2 more
exaly   +3 more sources

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Cytosine-5-methyltransferases add aldehydes to DNA

Nature Chemical Biology, 2009
Targeted methylation of cytosine residues by S-adenosylmethionine-dependent DNA methyltransferases modulates gene expression in vertebrates. Here we show that cytosine-5-methyltransferases catalyze reversible covalent addition of exogenous aliphatic aldehydes to their target residues in DNA, thus yielding corresponding 5-hydroxyalkylcytosines.
Zita Liutkevičiūtė, Gražvydas Lukinavičius, Dalia Daujotytė   +2 more
exaly   +4 more sources

Purification of human DNA (cytosine‐5‐)‐methyltransferase

Journal of Cellular Biochemistry, 1985
AbstractWe have developed a facile procedure for the purification of DNA methyltransferase activity from human placenta. The procedure avoids the isolation of nuclei and the dialysis and chromatography of large volumes. A purification of 38,000‐fold from the whole cell extract has been achieved.
K E, Zucker, A D, Riggs, S S, Smith
openaire   +2 more sources

Mammalian DNA (cytosine-5) methyltransferases and their expression

Clinical Immunology, 2003
Two classes of functional DNA (cytosine-5) methyltransferases have been discovered in mammals to date. One class methylates the unmodified DNA and is designated as the de novo enzyme, whereas the other maintains the methylation status of the daughter strand during DNA replication and thus is referred to as a maintenance DNA methyltransferase.
Sriharsa, Pradhan, Pierre-Olivier, Esteve   +1 more
openaire   +2 more sources

Recognition of foldback DNA by the human DNA (cytosine-5-) methyltransferase

Biochemistry, 1992
In order to specify the recognition requirements of the human DNA (cytosine-5-)-methyltransferase, two isomeric 48mers were synthesized so as to link a long block of DNA with a shorter complementary block of DNA through a tether consisting of five thymidine residues.
S S, Smith, R G, Lingeman, B E, Kaplan
openaire   +2 more sources

Plant cytosine-5 DNA methyltransferases: Structure, function, and molecular evolution

Genomics, 2007
A detailed analysis of the structure and function, along with evolutionary aspects, of the main plant cytosine-5 DNA methyltransferases (C5-MTases) is presented. The evolutionary relationships between the already known and four candidate plant C5-MTases identified in this work were investigated using the distance, maximum-parsimony, and maximum ...
Sophia Kossida
exaly   +4 more sources