Results 231 to 240 of about 94,067 (257)

DNA (cytosine-5)-methyltransferase 3B - [Isoform 1]

Targeted Protein Database, 2008
A DNMT3B (DNMT3B , DNA (cytos ine-5)methyltransferase 3B; Swiss-Prot accession number: Q9UBC3) gene deletion construct in which exons 16–19 were deleted was used to generate Dnmt3b-null ES cells and animals. The deleted region encodes the highly conserved PC (proline cysteine) and ENV (glutamic acid, asparagine, valine) motifs that are crucial for ...
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Regulation of Expression and Activity of DNA (Cytosine-5) Methyltransferases in Mammalian Cells

2011
Three active DNA (cytosine-5) methyltransferases (DNMTs) have been identified in mammalian cells, Dnmt1, Dnmt3a, and Dnmt3b. DNMT1 is primarily a maintenance methyltransferase, as it prefers to methylate hemimethylated DNA during DNA replication and in vitro. DNMT3A and DNMT3B are de novo methyltransferases and show similar activity on unmethylated and
Shannon R Morey, Kinney, Sriharsa, Pradhan   +1 more
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DNA (Cytosine-5) Methyltransferase Inhibitors: A Potential Therapeutic Agent for Schizophrenia

Molecular Pharmacology, 2007
In this issue of Molecular Pharmacology, Kundakovic et al. (p. 644) present compelling evidence suggesting that the promoters for reelin and GAD67 are coordinately regulated. The regulation occurs at the level of DNA (cytosine-5) methylation. Moreover, the authors present evidence suggesting that pharmacologic inhibition of DNA methyltransferase ...
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Biological Implications of the Mechanism of Action of Human DNA (Cytosine-5)methyltransferase

1994
Publisher Summary This chapter describes the enzymological boundaries of the phenomenon of human deoxyribonucleic acid (DNA) methylation, set by the specificity and mechanism of action of the human DNA methyltransferase(s). The formation of a tight, and presumably covalent, complex, between DNA, containing 5-azacytosine and DNA (cytosine-5 ...
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DNA (cytosine-5-)-methyltransferase

1996
Dietmar Schomburg, Dörte Stephan
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Recognition of structural perturbations in DNA by human DNA(cytosine-5)methyltransferase

Gene, 1988
D J, Baker, J L, Kan, S S, Smith
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Co-operation and communication between the human maintenance and de novo DNA (cytosine-5) methyltransferases

EMBO Journal, 2002
Richard J Roberts, Sriharsa Pradhan
exaly  

DNA (cytosine-5)-methyltransferases in mouse cells and tissues. studies with a mechanism-based probe

Journal of Molecular Biology, 1997
Jeffrey A Yoder, Gregory L Verdine, Timothy H Bestor   +2 more
exaly  

On the mechanism of inhibition of DNA-cytosine methyltransferases by cytosine analogs

Cell, 1983
Daniel V Santi, Philip J Barr
exaly  

Gilbert's conjecture: the search for DNA (cytosine-5) demethylases and the emergence of new functions for eukaryotic DNA (cytosine-5) methyltransferases.

Journal of molecular biology, 2000
In 1985 Walter Gilbert challenged members of the DNA methylation community assembled at a National Institutes of Health meeting organized by Giulio Cantoni and Ahron Razin with the following words: "The most exciting aspect about the methyl groups on DNA is the thought that they might provide a locally inherited change in a DNA structure.
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