Results 231 to 240 of about 95,440 (308)

A Review on Medicinal Chemistry and Biological Activity of Dihydropyrimidinones Against HIV

Archiv der Pharmazie, Volume 359, Issue 4, April 2026.
This article presents the latest advances in the development of dihydropyrimidinone (DHPM) derivatives as promising candidates against HIV. By exploring their interactions with essential viral targets and highlighting innovative compounds with potent antiviral activity, we provide an updated perspective on the opportunities for new antiretroviral ...
Debora I. Leite, Fernando B. Macedo, Murilo Marinho de C. Lima, Isabelle S. Brum, Jonathan Fragoso Miranda de Oliveira, Ana Clara S. Costa, Stella C. Duarte, Sarah Moon, Stefany de Castro B. Moura, Andressa P. de Oliveira, Nubia Boechat, Monica M. Bastos   +11 more
wiley   +1 more source

What is in a name? Rethinking SMUG1 in genome maintenance. [PDF]

NAR Cancer
Rudolfova N, Skjetne AM, Montaldo NP, Visnes T, Nilsen HL, Michel M.   +5 more
europepmc   +1 more source

Impact of influential data on screening epigenome-wide data. [PDF]

BMC Bioinformatics
Sultana S, Zhang H, Jiang Y, Abrar MNF, Arshad H, Xie L, Ray M.   +6 more
europepmc   +1 more source

Improved Messenger RNA Stability and Biocompatibility Through Self‐Gelatinizable Nucleic Acids

Biotechnology and Bioengineering, Volume 123, Issue 4, Page 1077-1086, April 2026.
ABSTRACT Recent advances in the chemical synthesis and modification of messenger RNA (mRNA) have generated growing interest in mRNA‐based therapeutics. However, the inherent instability of mRNA in vivo and during storage remains a major challenge, requiring the development of safe and effective delivery systems.
Takumi Tanifuji, Kosuke Kusamori, Chihiro Tanaka, Hideki Sakai, Shoko Itakura, Makiya Nishikawa   +5 more
wiley   +1 more source

Are i-Motif Structures in DNA Compatible with Cytosine-Ag(I)-Cytosine Base Pairs? [PDF]

Angew Chem Int Ed Engl
Seiffert V, López-Chamorro C, Barceló-Oliver M, Erbacher C, Karst U, Hebenbrock M, Kraatz HB, Galindo MA, Müller J.   +8 more
europepmc   +1 more source

Covalent Attachment of a Platinum(II) Complex inside DNA Duplexes

ChemistryEurope, Volume 4, Issue 4, April 2026.
Oxidative addition is used for the site‐specific incorporation of an organometallic PtII complex as an artificial nucleobase into a DNA duplex. The platination stabilizes the duplex and confers it with phosphorescence. An organometallic phosphorescent PtII complex is introduced into DNA duplexes via oxidative addition to a tailor‐made artificial ...
Tim Schäfer, Iván Maisuls, Felix Boisten, Marian Hebenbrock, Alexander Hepp, Cristian A. Strassert, Jens Müller   +6 more
wiley   +1 more source

Studies on copper (II) interaction with the (CCG)₁₂ repeats sequence: An insight into genomic instability in neurodegeneration. [PDF]

J Alzheimers Dis Rep
Emani LS, Rao JK, Dasappa JK, Narayan P, Mullur G, Avula P, Kosagisharaf JR.   +6 more
europepmc   +1 more source

Teriflunomide Attenuates Demyelination and Enhances Remyelination in Organotypic Brain Slice Cultures Through Modulation of Glial Cell Dynamics

CNS Neuroscience &Therapeutics, Volume 32, Issue 4, April 2026.
In an organotypic cerebellar slice culture (OSC) ex vivo demyelination model, teriflunomide has been shown to positively affect myelin preservation during demyelination and enhance remyelination. This is hypothesized as being achieved by modulating the dynamics of glial cells.
Jessica Kronenberg, Lara‐Jasmin Schröder, Henriette Reinsberg, Thomas Skripuletz, Sandra Heckers, Florian Hansmann, Wolfgang Baumgärtner, Martin Stangel, Viktoria Gudi   +8 more
wiley   +1 more source

Editing and synthetic engineering of chloroplast genomes. [PDF]

Plant Commun
Fu J, Zhang J.
europepmc   +1 more source

The First Complete Mitochondrial Genome of Common Hedge Blue Acytolepis puspa (Lepidoptera: Lycaenidae), and Comparative Genomic Analysis Within Polyommatinae

Ecology and Evolution, Volume 16, Issue 4, April 2026.
This study firstly reports the complete mitochondrial genome of Acytolepis puspa, providing an important mitogenomic reference for the previously unrepresented genus Acytolepis. ABSTRACT The butterfly genus Acytolepis (Lepidoptera: Lycaenidae: Polyommatinae) is widely distributed in the Indomalayan and Australasian realms.
Muyang Li, Dan Zhang, Jianping Zhang, Dongkai Liu, Xianfeng Yi, Ran Li   +5 more
wiley   +1 more source