Results 1 to 10 of about 1,030,705 (227)
Signal Transduction and Targeted Therapy, 2021 Genomic instability is the hallmark of various cancers with the increasing accumulation of DNA damage. The application of radiotherapy and chemotherapy in cancer treatment is typically based on this property of cancers.
Ruixue Huang, Ping-Kun Zhou
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DNA damage induced during mitosis undergoes DNA repair synthesis. [PDF]
PLoS ONE, 2020 Understanding the mitotic DNA damage response (DDR) is critical to our comprehension of cancer, premature aging and developmental disorders which are marked by DNA repair deficiencies.
Veronica Gomez Godinez +10 more
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DNA Damage, Mutagenesis, and DNA Repair [PDF]
Journal of Nucleic Acids, 2010 This special issue of the Journal of Nucleic Acids is dedicated to DNA damage and two important biological consequences provoked by such damage: lesion repair and lesion-induced mutagenesis. These phenomena have attracted broad interest among a large community of scientists that cross disciplines from mathematics, physics, chemistry, and biology to ...
Ashis Basu +3 more
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H3K36me3, message from chromatin to DNA damage repair
Cell & Bioscience, 2020 Histone marks control many cellular processes including DNA damage repair. This review will focus primarily on the active histone mark H3K36me3 in the regulation of DNA damage repair and the maintenance of genomic stability after DNA damage.
Zhongxing Sun +6 more
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DNA Damage, Repair, and Cancer Metabolism
Frontiers in Oncology, 2018 Although there has been a renewed interest in the field of cancer metabolism in the last decade, the link between metabolism and DNA damage/DNA repair in cancer has yet to be appreciably explored.
Marc-Olivier Turgeon +3 more
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RNase H enables efficient repair of R-loop induced DNA damage [PDF]
eLife, 2016 R-loops, three-stranded structures that form when transcripts hybridize to chromosomal DNA, are potent agents of genome instability. This instability has been explained by the ability of R-loops to induce DNA damage. Here, we show that persistent R-loops
Jeremy D Amon, Douglas Koshland
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DNA Methyltransferases, DNA Damage Repair, and Cancer [PDF]
Advances in Experimental Medicine and Biology, 2012 The maintenance DNA methyltransferase (DNMT) 1 and the de novo methyltransferases DNMT3A and DNMT3B are all essential for mammalian development. DNA methylation, catalyzed by the DNMTs, plays an important role in maintaining genome stability. Aberrant expression of DNMTs and disruption of DNA methylation patterns are closely associated with many forms ...
Bilian, Jin, Keith D, Robertson
openaire +3 more sources
Nature, 2003 The aesthetic appeal of the DNA double helix initially hindered notions of DNA mutation and repair, which would necessarily interfere with its pristine state. But it has since been recognized that DNA is subject to continuous damage and the cell has an arsenal of ways of responding to such injury.
Michaela Cichon +2 more
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YTHDF1 promotes breast cancer cell growth, DNA damage repair and chemoresistance
Cell Death and Disease, 2022 Chemoresistance represents a major obstacle to the treatment of human cancers. Increased DNA repair capacity is one of the important mechanisms underlying chemoresistance.
Yu Sun +5 more
semanticscholar +1 more source
Loop extrusion as a mechanism for DNA damage repair foci formation
Nature, 2021 The repair of DNA double-strand breaks (DSBs) is essential for safeguarding genome integrity. When a DSB forms, the PI3K-related ATM kinase rapidly triggers the establishment of megabase-sized, chromatin domains decorated with phosphorylated histone H2AX
C. Arnould +12 more
semanticscholar +1 more source