Results 1 to 10 of about 976,410 (209)
Signal Transduction and Targeted Therapy, 2021 Genomic instability is the hallmark of various cancers with the increasing accumulation of DNA damage. The application of radiotherapy and chemotherapy in cancer treatment is typically based on this property of cancers.
Ruixue Huang, Ping-Kun Zhou
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DNA damage induced during mitosis undergoes DNA repair synthesis. [PDF]
PLoS ONE, 2020 Understanding the mitotic DNA damage response (DDR) is critical to our comprehension of cancer, premature aging and developmental disorders which are marked by DNA repair deficiencies.
Veronica Gomez Godinez +10 more
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H3K36me3, message from chromatin to DNA damage repair
Cell & Bioscience, 2020 Histone marks control many cellular processes including DNA damage repair. This review will focus primarily on the active histone mark H3K36me3 in the regulation of DNA damage repair and the maintenance of genomic stability after DNA damage.
Zhongxing Sun +6 more
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DNA Damage, Repair, and Cancer Metabolism
Frontiers in Oncology, 2018 Although there has been a renewed interest in the field of cancer metabolism in the last decade, the link between metabolism and DNA damage/DNA repair in cancer has yet to be appreciably explored.
Marc-Olivier Turgeon +3 more
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RNase H enables efficient repair of R-loop induced DNA damage [PDF]
eLife, 2016 R-loops, three-stranded structures that form when transcripts hybridize to chromosomal DNA, are potent agents of genome instability. This instability has been explained by the ability of R-loops to induce DNA damage. Here, we show that persistent R-loops
Jeremy D Amon, Douglas Koshland
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YTHDF1 promotes breast cancer cell growth, DNA damage repair and chemoresistance
Cell Death and Disease, 2022 Chemoresistance represents a major obstacle to the treatment of human cancers. Increased DNA repair capacity is one of the important mechanisms underlying chemoresistance.
Yu Sun +5 more
semanticscholar +1 more source
Loop extrusion as a mechanism for DNA damage repair foci formation
Nature, 2021 The repair of DNA double-strand breaks (DSBs) is essential for safeguarding genome integrity. When a DSB forms, the PI3K-related ATM kinase rapidly triggers the establishment of megabase-sized, chromatin domains decorated with phosphorylated histone H2AX
C. Arnould +12 more
semanticscholar +1 more source
Isolation of human and murine hematopoietic stem cells for DNA damage and DNA repair assays
STAR Protocols, 2021 Summary: Hematopoietic stem and progenitor cells (HSPCs) reside in the bone marrow and supply blood cells. Efficient methods for isolation of HSPCs are required. Here, we present protocols for the isolation of human and murine HSPCs using manual and FACS-
Alfredo Rodríguez +5 more
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Uncovering an allosteric mode of action for a selective inhibitor of human Bloom syndrome protein
eLife, 2021 BLM (Bloom syndrome protein) is a RECQ-family helicase involved in the dissolution of complex DNA structures and repair intermediates. Synthetic lethality analysis implicates BLM as a promising target in a range of cancers with defects in the DNA damage ...
Xiangrong Chen +13 more
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MRN complex is an essential effector of DNA damage repair
Journal of Zhejiang University SCIENCE B, 2021 Genome stability can be threatened by both endogenous and exogenous agents. Organisms have evolved numerous mechanisms to repair DNA damage, including homologous recombination (HR) and non-homologous end joining (NHEJ).
Shan Qiu, Jun Huang
semanticscholar +1 more source