Results 11 to 20 of about 976,559 (349)
DNA damage, homology-directed repair, and DNA methylation.
PLoS Genetics, 2007 To explore the link between DNA damage and gene silencing, we induced a DNA double-strand break in the genome of Hela or mouse embryonic stem (ES) cells using I-SceI restriction endonuclease. The I-SceI site lies within one copy of two inactivated tandem
Concetta Cuozzo +13 more
doaj +8 more sources
DNA Damage, Mutagenesis, and DNA Repair [PDF]
Journal of Nucleic Acids, 2010 This special issue of the Journal of Nucleic Acids is dedicated to DNA damage and two important biological consequences provoked by such damage: lesion repair and lesion-induced mutagenesis. These phenomena have attracted broad interest among a large community of scientists that cross disciplines from mathematics, physics, chemistry, and biology to ...
Ashis Basu +3 more
doaj +3 more sources
Nature, 2003 The aesthetic appeal of the DNA double helix initially hindered notions of DNA mutation and repair, which would necessarily interfere with its pristine state. But it has since been recognized that DNA is subject to continuous damage and the cell has an arsenal of ways of responding to such injury.
Michaela Cichon +2 more
+6 more sources
Radiobiology Summaries: DNA Damage and Repair [PDF]
Clinical Oncology, 2021 No abstract available.
Chalmers, A.J., Carruthers, R.D.
openaire +3 more sources
DNA methyltransferases, DNA damage repair, and cancer. [PDF]
Advances in Experimental Medicine and Biology, 2013 The maintenance DNA methyltransferase (DNMT) 1 and the de novo methyltransferases DNMT3A and DNMT3B are all essential for mammalian development. DNA methylation, catalyzed by the DNMTs, plays an important role in maintaining genome stability. Aberrant expression of DNMTs and disruption of DNA methylation patterns are closely associated with many forms ...
Bilian Jin, K. Robertson
semanticscholar +3 more sources
PTEN in DNA damage repair [PDF]
Cancer Letters, 2012 The ability of DNA repair in a cell is vital to its genomic integrity and thus to the normal functioning of an organism. Phosphatase and tensin homolog (PTEN) is a well-established tumor suppressor gene that induces apoptosis and controls cell growth by inhibiting the PI3K/AKT pathway.
Mei, Ming, Yu-Ying, He
openaire +2 more sources
Research progress on the role and mechanism of DNA damage repair in germ cell development
Frontiers in Endocrinology, 2023 In the complex and dynamic processes of replication, transcription, and translation of DNA molecules, a large number of replication errors or damage can occur which lead to obstacles in the development process of germ cells and result in a decreased ...
Yan Wang +9 more
doaj +1 more source
Cohesin causes replicative DNA damage by trapping DNA topological stress [PDF]
, 2020 DNA topological stress inhibits DNA replication fork (RF) progression and contributes to DNA replication stress. In Saccharomyces cerevisiae, we demonstrate that centromeric DNA and the rDNA array are especially vulnerable to DNA topological stress ...
Baxter, Jonathan +2 more
core +1 more source
DNA Damage Repair and Current Therapeutic Approaches in Gastric Cancer: A Comprehensive Review
Frontiers in Genetics, 2022 DNA in cells is frequently damaged by endogenous and exogenous agents. However, comprehensive mechanisms to combat and repair DNA damage have evolved to ensure genomic stability and integrity.
Menghui Wang, Chuan Xie
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Cooperation of the ATM and Fanconi Anemia/BRCA Pathways in Double-Strand Break End Resection
Cell Reports, 2020 Summary: Cells deficient in ataxia telangiectasia mutated (ATM) are hypersensitive to ionizing radiation and other anti-cancer agents that induce double-strand DNA breaks. ATM inhibitors may therefore sensitize cancer cells to these agents.
Mu-Yan Cai +9 more
doaj +1 more source