Results 61 to 70 of about 976,559 (349)
Biophysical Reports, 2021 Mapping DNA damage and its repair has immense potential in understanding environmental exposures, their genotoxicity, and their impact on human health.
Noa Gilat +6 more
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DNA Repair by Reversal of DNA Damage [PDF]
Cold Spring Harbor Perspectives in Biology, 2013 Endogenous and exogenous factors constantly challenge cellular DNA, generating cytotoxic and/or mutagenic DNA adducts. As a result, organisms have evolved different mechanisms to defend against the deleterious effects of DNA damage. Among these diverse repair pathways, direct DNA-repair systems provide cells with simple yet efficient solutions to ...
Chengqi, Yi, Chuan, He
openaire +3 more sources
The Histone-Fold Protein CHRAC14 Influences Chromatin Composition in Response to DNA Damage
Cell Reports, 2014 Summary: Chromatin reorganization and the incorporation of specific histone modifications during DNA damage response are essential steps for the successful repair of any DNA lesion.
Veena Mathew +5 more
doaj +1 more source
Frontiers in Neuroscience, 2023 Emerging evidence suggests cellular senescence, as a consequence of excess DNA damage and deficient repair, to be a driver of brain dysfunction following repeated mild traumatic brain injury (rmTBI).
Emily Leung +6 more
doaj +1 more source
Effects of an Unusual Poison Identify a Lifespan Role for Topoisomerase 2 in Saccharomyces Cerevisiae [PDF]
, 2017 A progressive loss of genome maintenance has been implicated as both a cause and consequence of aging. Here we present evidence supporting the hypothesis that an age-associated decay in genome maintenance promotes aging in Saccharomyces cerevisiae (yeast)
Baxter, Bonnie +13 more
core +2 more sources
Repairing DNA damage in chromatin
Biochimie, 2003 Understanding how DNA repair processes occur in vivo when access to DNA is hindered by chromatin structural organisation is a current challenge. In general terms, the following sequence of events has to be considered within a chromatin environment: (i) finding a lesion (ii) repairing this lesion, and (iii) full restoration of a functional chromatin ...
Gontijo, A, Green, C, Almouzni, G
openaire +2 more sources
DNA Repair Pathways in Cancer Therapy and Resistance
Frontiers in Pharmacology, 2021 DNA repair pathways are triggered to maintain genetic stability and integrity when mammalian cells are exposed to endogenous or exogenous DNA-damaging agents.
Lan-ya Li +5 more
doaj +1 more source
The Adaptive Significance of Natural Genetic Variation in the DNA Damage Response of Drosophila melanogaster. [PDF]
, 2016 Despite decades of work, our understanding of the distribution of fitness effects of segregating genetic variants in natural populations remains largely incomplete. One form of selection that can maintain genetic variation is spatially varying selection,
Begun, David J +3 more
core +4 more sources
Regulation of murine NK cell exhaustion through the activation of the DNA damage repair pathway.
JCI Insight, 2019 NK cell exhaustion (NCE) due to sustained proliferation results in impaired NK cell function with loss of cytokine production and lytic activity. Using murine models of chronic NK cell stimulation, we have identified a phenotypic signature of NCE ...
Maite Álvarez +7 more
semanticscholar +1 more source
DNA repair: How yeast repairs radical damage [PDF]
Current Biology, 1996 Cloning of the OGG1 gene from Saccharomyces cerevisiae has revealed that DNA glycosylases are not necessarily conserved throughout phylogeny, yet there is a DNA-repair protein superfamily with a wide substrate specificity found from bacteria to man.
openaire +2 more sources