Results 61 to 70 of about 1,030,824 (346)

Repair, abort, ignore? Strategies for dealing with UV damage [PDF]

, 2011
DNA repair is a prominent member of the nuclear transactions triad (replication, transcription, and repair). Sophisticated mechanisms govern the cellular process of decision-making (to repair or not to repair, to proceed with cell cycle or not and ...
Khalil, Hilal S., Tummala, Hemanth, Zhelev, Nikolai   +2 more
core   +3 more sources

BRCA1 heterozygosity promotes DNA damage-induced senescence in a sex-specific manner following repeated mild traumatic brain injury

Frontiers in Neuroscience, 2023
Emerging evidence suggests cellular senescence, as a consequence of excess DNA damage and deficient repair, to be a driver of brain dysfunction following repeated mild traumatic brain injury (rmTBI).
Emily Leung, Emily Leung, Daria Taskina, Nicole Schwab, Nicole Schwab, Lili-Naz Hazrati, Lili-Naz Hazrati   +6 more
doaj   +1 more source

Repairing DNA damage in chromatin

Biochimie, 2003
Understanding how DNA repair processes occur in vivo when access to DNA is hindered by chromatin structural organisation is a current challenge. In general terms, the following sequence of events has to be considered within a chromatin environment: (i) finding a lesion (ii) repairing this lesion, and (iii) full restoration of a functional chromatin ...
Gontijo, A, Green, C, Almouzni, G
openaire   +2 more sources

Contribution of DNA repair and cell cycle checkpoint arrest to the maintenance of genomic stability [PDF]

, 2006
DNA damage response mechanisms encompass pathways of DNA repair, cell cycle checkpoint arrest and apoptosis. Together, these mechanisms function to maintain genomic stability in the face of exogenous and endogenous DNA damage.
Ahnesorg, Buck, Calsou, Chappell, Chun, Cui, Difilippantonio, Dore, Fernandez-Capetillo, Frank, Gao, Gladdy, Hefferin, Hirao, Jeggo, Jeggo, Kemp, Kuhne, Kurz, Lavin, Lee, Liu, Lobrich, Lukas, Ma, Markus Löbrich, Moshous, Moshous, Nick McElhinny, Penny A. Jeggo, Poinsignon, Riballo, Rooney, Rothkamm, Stankovic, Stankovic, Terzoudi, Walker, Wang, Weterings, Wyman, Zhang   +41 more
core   +1 more source

The Histone-Fold Protein CHRAC14 Influences Chromatin Composition in Response to DNA Damage

Cell Reports, 2014
Summary: Chromatin reorganization and the incorporation of specific histone modifications during DNA damage response are essential steps for the successful repair of any DNA lesion.
Veena Mathew, Anne-Laure Pauleau, Natascha Steffen, Andrea Bergner, Peter B. Becker, Sylvia Erhardt   +5 more
doaj   +1 more source

DNA Repair Pathways in Cancer Therapy and Resistance

Frontiers in Pharmacology, 2021
DNA repair pathways are triggered to maintain genetic stability and integrity when mammalian cells are exposed to endogenous or exogenous DNA-damaging agents.
Lan-ya Li, Lan-ya Li, Yi-di Guan, Xi-sha Chen, Jin-ming Yang, Yan Cheng   +5 more
doaj   +1 more source

Only complete rejoining of DNA strand breaks after UVC allows K562 cell proliferation and DMSO induction of erythropoiesis [PDF]

, 2008
DNA strand breaks are early intermediates of the repair of UVC-induced DNA damage, however, since they severely impair cellular activities, their presence should be limited in time.
AVALLONE, BICE, FORESTI, MAGDA
core   +1 more source

A methylation-phosphorylation switch determines Plk1 kinase activity and function in DNA damage repair

Science Advances, 2019
Two types of small-group modifications on Plk1 control its activity and its cellular functions. Polo-like kinase 1 (Plk1) is a crucial regulator of cell cycle progression; but the mechanism of regulation of Plk1 activity is not well understood.
Weizhe Li, Hong-Yan Wang, Xiaolu Zhao, Hongguo Duan, Binghua Cheng, Yafei Liu, Mengjie Zhao, Wen-Jie Shu, Yuchao Mei, Zengqi Wen, Mingliang Tang, Lin Guo, Guohong Li, Qiang Chen, Xiaoqi Liu, Hai-Ning Du   +15 more
semanticscholar   +1 more source

Jianpi-yangwei decoction inhibits DNA damage repair in the drug resistance of gastric cancer by reducing FEN1 expression

BMC Complementary Medicine and Therapies, 2020
Background Flap Endonuclease 1(FEN1) has been considered as a new tumor marker in recent years and Jianpi Yangwei Decoction (JPYW) is a basic Traditional Chinese Medicine (TCM) for the treatment of gastric cancer.
Wenjie Huang, Huijuan Tang, Fang Wen, Xiaona Lu, Qingpei Li, Peng Shu   +5 more
doaj   +1 more source

DNA repair: How yeast repairs radical damage [PDF]

Current Biology, 1996
Cloning of the OGG1 gene from Saccharomyces cerevisiae has revealed that DNA glycosylases are not necessarily conserved throughout phylogeny, yet there is a DNA-repair protein superfamily with a wide substrate specificity found from bacteria to man.
openaire   +2 more sources