Results 121 to 130 of about 1,846,477 (392)

BRIT1/MCPH1 links chromatin remodelling to DNA damage response [PDF]

, 2009
To detect and repair damaged DNA, DNA damage response proteins need to overcome the barrier of condensed chromatin to gain access to DNA lesions1. ATP-dependent chromatin remodeling is one of the fundamental mechanisms used by cells to relax chromatin in
AA Goodarzi, AA Sartori, AJ Morrison, AJ Pierce, Andrew P. Jackson, AP Jackson, B Chai, CL Peterson, CWM Roberts, Eun-Kyoung Yim, GJ Narlikar, GK Alderton, Guang Peng, H van Attikum, Hui Dai, Ineke van der Burgt, J Chen, JA Martens, JH Park, JL Wood, JL Wood, K Nakanishi, Kaiyi Li, L Zou, LA Boyer, Mei-Ren Pan, ML Phelan, MR Lieber, P Sung, R Rai, R Scully, Ruozhen Hu, S Matsuoka, Shiaw-Yih Lin, SY Lin, SY Lin, T Tsukuda, TK Pandita, U Rass, X Xu, X Yu, Y Ziv   +41 more
core   +2 more sources

DNA Damage Response and Oxidative Stress in Systemic Autoimmunity

International Journal of Molecular Sciences, 2019
The DNA damage response and repair (DDR/R) network, a sum of hierarchically structured signaling pathways that recognize and repair DNA damage, and the immune response to endogenous and/or exogenous threats, act synergistically to enhance cellular ...
V. Souliotis, N. Vlachogiannis, M. Pappa, A. Argyriou, Panagiotis A. Ntouros, P. Sfikakis   +5 more
semanticscholar   +1 more source

PARP inhibitors elicit distinct transcriptional programs in homologous recombination competent castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
PARP inhibitors are used to treat a small subset of prostate cancer patients. These studies reveal that PARP1 activity and expression are different between European American and African American prostate cancer tissue samples. Additionally, different PARP inhibitors cause unique and overlapping transcriptional changes, notably, p53 pathway upregulation.
Moriah L. Cunningham, Jasibel Vasquez‐Gonzalez, Samantha M. Barnada, Salome Tchotorlishvili, Latese Jones, Ryan Maguire, Genevieve Lewis, Kinza Rizwan, Jenny Deng, Salma Koachar, Drithi Patel, Hailey Shankle, Tessa Mulders, Namra Ajmal, Charalambos Solomides, Emad S. Alnemri, Teresa F. Alnemri, Ayesha A. Shafi, Leonard G. Gomella, Wm Kevin Kelly, Steven B. McMahon, Matthew J. Schiewer   +21 more
wiley   +1 more source

The Histone-Fold Protein CHRAC14 Influences Chromatin Composition in Response to DNA Damage

Cell Reports, 2014
Summary: Chromatin reorganization and the incorporation of specific histone modifications during DNA damage response are essential steps for the successful repair of any DNA lesion.
Veena Mathew, Anne-Laure Pauleau, Natascha Steffen, Andrea Bergner, Peter B. Becker, Sylvia Erhardt   +5 more
doaj   +1 more source

Absence of ERK5/MAPK7 delays tumorigenesis in Atm-/- mice [PDF]

, 2017
Ataxia-telangiectasia mutated (ATM) is a cell cycle checkpoint kinase that upon activation by DNA damage leads to cell cycle arrest and DNA repair or apoptosis.
Angulo Ibáñez, María, Espel Masferrer, Enric, Granados Jaén, Alba, Reina del Pozo, Manuel, Rovira Clavé, Xavier, Soriano Zaragoza, Francesc X. (Francesc Xavier), Vasquez Gamez, Celina Paola   +6 more
core   +1 more source

Adenosine‐to‐inosine editing of miR‐200b‐3p is associated with the progression of high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
A‐to‐I editing of miRNAs, particularly miR‐200b‐3p, contributes to HGSOC progression by enhancing cancer cell proliferation, migration and 3D growth. The edited form is linked to poorer patient survival and the identification of novel molecular targets.
Magdalena Niemira, Anna Skwarska, Karolina Chwialkowska, Agnieszka Ostrowska, Gabriela Sokolowska, Anna Zeller, Anna Erol, Andrzej Eljaszewicz, Bartosz Hanczaruk, Anna Michalska‐Falkowska, Agnieszka Tarasik, Joanna Reszec‐Gielazyn, Pawel Knapp, Marcin Moniuszko, Adam Kretowski   +14 more
wiley   +1 more source

Induction of Stress Granule Assembly is Essential for the Orchestration of DNA Damage Response [PDF]

, 2008
DNA damage provokes several responses including DNA repair, cell cycle regulation and apoptosis that collectively represent the DNA damage response (DDR).
Nicole S. Verkaik, Stephan Persengiev
core   +1 more source

Beyond DNA repair: DNA-PK function in cancer. [PDF]

, 2014
UNLABELLED: The DNA-dependent protein kinase (DNA-PK) is a pivotal component of the DNA repair machinery that governs the response to DNA damage, serving to maintain genome integrity.
Goodwin, Jonathan F, Knudsen, Karen E
core   +1 more source

Preserving genome integrity and function: the DNA damage response and histone modifications

Critical reviews in biochemistry and molecular biology, 2019
Modulation of chromatin templates in response to cellular cues, including DNA damage, relies heavily on the post-translation modification of histones.
Jae Jin Kim, S. Lee, K. Miller
semanticscholar   +1 more source

Integrated genomic and proteomic profiling reveals insights into chemoradiation resistance in cervical cancer

Molecular Oncology, EarlyView.
A comprehensive genomic and proteomic analysis of cervical cancer revealed STK11 and STX3 as a potential biomarkers of chemoradiation resistance. Our study demonstrated EGFR as a therapeutic target, paving the way for precision strategies to overcome treatment failure and the DNA repair pathway as a critical mechanism of resistance.
Janani Sambath, Irene A. George, Srikanth S. Manda, Prasanth Ariyannur, Ekta R. Dhawale, Raja Sekhar Kommu, Rajan Datar, Darshana Patil, Vinita Trivedi, Manisha Singh, Kumar Prabhash, Sewanti Limaye, Richa Chauhan, Prashant Kumar   +13 more
wiley   +1 more source