Results 161 to 170 of about 671,892 (268)

CSF Levels of NPTX2 Are Associated With Less Brain Atrophy Over Time in Cognitively Unimpaired Individuals

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Introduction Neuronal pentraxin 2 (NPTX2) is a synaptic protein involved in synaptic plasticity and regulation of neuronal excitability. Lower baseline cerebrospinal fluid (CSF) NPTX2 levels have been shown to be associated with an earlier onset of mild cognitive impairment (MCI), a pre‐dementia syndrome, even after CSF Alzheimer's Disease (AD)
Juan P. Vazquez, Corinne Pettigrew, Yuxin Zhu, Claire Anderson, Guray Erus, Christos Davatzikos, Michael Miller, Abhay Moghekar, Sungtaek Oh, Chan‐Hyun Na, Marilyn Albert, Paul Worley, Anja Soldan   +12 more
wiley   +1 more source

Table S4 from E2F1-Associated Purine Synthesis Pathway Is a Major Component of the MET-DNA Damage Response Network

Michaela Poliaková Turan, Rahel Riedo, Matúš Medo, Chiara Pozzato, Manja Friese‐Hamim, Jonas P. Koch, Si’Ana A. Coggins, Qun Li, Baek Kim, Joachim Albers, Daniel M. Aebersold, Nicola Zamboni, Yitzhak Zimmer, Michaela Medová   +13 more
openalex   +1 more source

Lack of DNA Damage Response at Low Radiation Doses in Adult Stem Cells Contributes to Organ Dysfunction [PDF]

, 2018
Peter W. Nagle, Nynke A. Hosper, Lara Barazzuol, Anne L. Jellema, Mirjam Baanstra, Marc‐Jan van Goethem, S. Brandenburg, U. Giesen, Johannes A. Langendijk, Peter van Luijk, Robert P. Coppes   +10 more
openalex   +1 more source

Telomeric DNA damage response mediates neurotoxicity of Aβ42 oligomers in Alzheimer's disease. [PDF]

EMBO J
Sepe S, Rey F, Mancheno-Ferris A, Bigi A, Fani G, Damiani D, Cabrini M, Marinelli E, Aguado J, Contu L, di Lillo A, Boggio S, Tavella S, Rosso I, Gustincich S, Chiti F, d'Adda di Fagagna F.   +16 more
europepmc   +1 more source

Nationwide Characterization of MFN2‐Related CMT in 176 Japanese Patients: Clinical and Genetic Insights

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background Mitofusin 2 (MFN2) is a major causative gene for axonal Charcot – Marie – Tooth disease type 2A (CMT2A), with a wide phenotypic spectrum. Comprehensive large ‐ scale genotype – phenotype association studies are essential for understanding disease pathogenesis and improved clinical management.
Masahiro Ando, Yujiro Higuchi, Jun‐Hui Yuan, Akiko Yoshimura, Chikashi Yano, Takahiro Hobara, Fumikazu Kojima, Yu Hiramatsu, Satoshi Nozuma, Tomonori Nakamura, Yusuke Sakiyama, Jun Mitsui, Shoji Tsuji, Hiroshi Takashima   +13 more
wiley   +1 more source

Programmed cell death 6, a novel p53‐responsive gene, targets to the nucleus in the apoptotic response to DNA damage [PDF]

, 2012
K. Suzuki, Nurmaa K. Dashzeveg, Zheng‐Guang Lu, Naoe Taira, Yoshio Miki, Kiyotsugu Yoshida   +5 more
openalex   +1 more source

Impact of APOE ε4 Genotype Load on Cognitive Function and Lipid Metabolism in Patients With Cerebral Small Vessel Disease

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background Apolipoprotein ε4 (APOE ε4) is a potent genetic risk factor for Alzheimer's disease (AD). However, its role in cerebral small vessel disease (CSVD) remains unclear. Given the clinical and pathological similarities between CSVD and AD, this study aimed to investigate the associations of APOE ε4 gene dosage with cognitive function and
Tingru Jin, Haocheng Yang, Feng Liu, Sihao Lin, Junru Hu, Jian Wang, Yulan Gou   +6 more
wiley   +1 more source

DNA damage response and hematological malignancy [PDF]

, 2017
Masatoshi Takagi
openalex   +1 more source

IFI16 Enhances Chemosensitivity of Breast Cancer Cells by Inhibiting DNA Damage Response. [PDF]

Biomol Ther (Seoul)
Ka NL, Lim GY, Kim SS, Lee MO.
europepmc   +1 more source

RAB39B Related Parkinsonism in an Italian Family: A Unique Use of Advanced Therapies

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Parkinson's disease (PD) is a neurodegenerative disorder that may sometimes be caused by deleterious genetic variants. Among them, RAB39B polymorphisms are known as rare causes of early‐onset PD associated with intellectual disability (Waisman's syndrome).
Caterina Del Regno, Giovanni Ermanis, Christian Lettieri, Andrea Bernardini, Gaia Pellitteri, Enrico Belgrado, Elena Betto, Gian Luigi Gigli, David De Monte, Marco Domenico Scanni, Marco Mucchiut, Giuseppe Damante, Mariarosaria Valente, Francesco Janes   +13 more
wiley   +1 more source