Results 171 to 180 of about 1,204,389 (301)

Digital twins to accelerate target identification and drug development for immune‐mediated disorders

FEBS Open Bio, EarlyView.
Digital twins integrate patient‐derived molecular and clinical data into personalised computational models that simulate disease mechanisms. They enable rapid identification and validation of therapeutic targets, prediction of drug responses, and prioritisation of candidate interventions.
Anna Niarakis, Philippe Moingeon
wiley   +1 more source

Implications of DNA damage response and immunotherapy in tumor therapy. [PDF]

Cell Commun Signal
Li W, Li B, Cai C, Chen J, Li Y, Liang R, Zhao J.   +6 more
europepmc   +1 more source

Evolutionarily divergent DUF4465 domains have a common vitamin B12‐binding function

FEBS Open Bio, EarlyView.
We show that DUF4465 family proteins, widespread across bacteria from gut microbiomes, hydrothermal vents, and soil, share a common vitamin B12‐binding function. These augmented β‐jellyroll proteins bind vitamin B12 via extended loops. Our findings establish sequence‐diverse DUF4465 proteins as a widespread class of B12‐binding proteins, highlighting ...
Charlea Clarke, Michal Banasik, Rokas Juodeikis, Martin J. Warren, Richard W. Pickersgill   +4 more
wiley   +1 more source

Transcription activation mechanism of a noncanonical DNA damage response pathway by the WYL-activator, DriD. [PDF]

Sci Adv
Singh RR, Chinni A, Cannistraci E, Salinas R, Yadav S, Gozzi K, Schumacher MA.   +6 more
europepmc   +1 more source

Blood‐based proteomic profiling reveals context‐dependent changes in BCL2‐associated signaling during taxane therapy in breast cancer patients

FEBS Open Bio, EarlyView.
Chemotherapy side effects significantly impact cancer survivors' quality of life. Using protein levels in blood samples from breast cancer patients before and after 12 weeks of taxane treatment, we detected treatment‐dependent changes in calcium signaling and aging pathways associated with cancer recurrence.
Saira Munshani, Eiman Y. Ibrahim, Rozalyn L. Rodwin, Leah M. Ferrucci, Kim Blenman, Maryam Lustberg, Barbara E. Ehrlich   +6 more
wiley   +1 more source

Multiple myeloma risk linked to DNA damage response genes. [PDF]

J Hematol Oncol
Conry M, Ostrovnaya I, Kemel Y, Sinha S, Baughn LB, Avery B, Maclachlan K, Groner V, Banaszak L, Norman A, Boddicker NJ, Clay-Gilmour A, Kumar S, Kim E, Dandiker S, Waghmare M, Slager S, Sborov DW, Garber J, Brown EE, Hildebrandt M, Hari P, Camp N, Vachon C, Usmani S, Offit K, Joseph V.   +26 more
europepmc   +1 more source

Natural Products as Geroprotective Modulators in Diabetic Nephropathy: A Mechanistic Framework Integrating Aging Hallmarks and the AMPK–SIRT1–Nrf2 Axis

Aging and Cancer, EarlyView.
Natural products target the aging kidney in diabetic nephropathy by restoring the AMPK–SIRT1–Nrf2 axis, reducing oxidative stress, inflammation, fibrosis, and cellular senescence while enhancing mitochondrial biogenesis and antioxidant defenses.
Sherif Hamidu, Latif Adams, Eunice Ampem‐Danso, Justice Kumi, Abigail Aning, Fatima Hamidu, Mustapha Abdul Mumin Mohammed, Ayuba Nii Darku Ankrah, Seth Kwabena Amponsah   +8 more
wiley   +1 more source

Anti-Müllerian hormone ameliorates uterine DNA damage response and prevents pregnancy complications in doxorubicin-treated mice†. [PDF]

Biol Reprod
Nguyen NMP, Mermin-Bunnell AM, de Mattos K, Cleverdon J, Kano M, Chauvin M, Godin P, Kashiwagi A, Duong T, Nagykery N, Donahoe PK, Meinsohn MC, Pepin D.   +12 more
europepmc   +1 more source

Long‐Term Follow‐Up of Chemotherapy‐Associated Biological Aging in Women With Early Breast Cancer

Aging and Cancer, EarlyView.
Women threated with adjuvant chemotherapy for early breast cancer have sustained long‐term increase in p16INK4a,, a robust marker of cell senescence, suggesting a chemotherapy‐associated age acceleration. p16INK4a as well as other biomarkers may identify patients at greatest risk for senescence‐related diseases of aging.
Hyman B. Muss, Alexis C. Wardell, Allison M. Deal, Kirsten A. Nyrop, Allison Ross, Yara G. Abdou, Jeffrey D. Aldrich, Lisa A. Cary, E. Claire Dees, Katherine E. Reeder‐Hayes, Emily M. Ray, Natalia Mitin, Denis Tsygankov   +12 more
wiley   +1 more source

Synthetic lethality and DNA damage response targeting in cancer stem cells: a comprehensive review. [PDF]

Discov Oncol
Sayed U, Abdulsahib WK, Jasim IK, Malathi H, Nayak PP, Alex Anand D, Mukherjee G, Sinha A, Eshkaraev S.   +8 more
europepmc   +1 more source