Results 11 to 20 of about 1,846,477 (392)
Biomolecules, 2021 DNA in our cells is constantly modified by internal and external factors [...]
Valentyn Oksenych, Denis E. Kainov
doaj +6 more sources
Radiation induced DNA damage responses [PDF]
Radiation Protection Dosimetry, 2006 The amazing feature of ionising radiation (IR) as a DNA damaging agent is the range of lesions it induces. Such lesions include base damage, single strand breaks (SSBs), double strand breaks (DSBs) of varying complexity and DNA cross links.
Jeggo, Penny, Löbrich, Markus
core +4 more sources
Autophagy in DNA Damage Response [PDF]
International Journal of Molecular Sciences, 2015 DNA damage response (DDR) involves DNA repair, cell cycle regulation and apoptosis, but autophagy is also suggested to play a role in DDR. Autophagy can be activated in response to DNA-damaging agents, but the exact mechanism underlying this activation ...
Elzbieta Pawlowska +4 more
core +5 more sources
DNA Damage Response Pathways in Dinoflagellates [PDF]
Microorganisms, 2019 Dinoflagellates are a general group of phytoplankton, ubiquitous in aquatic environments. Most dinoflagellates are non-obligate autotrophs, subjected to potential physical and chemical DNA-damaging agents, including UV irradiation, in the euphotic zone ...
Chongping Li, Joseph Tin Yum Wong
doaj +4 more sources
Cold Spring Harbor Perspectives in Biology, 2010 Structural changes to DNA severely affect its functions, such as replication and transcription, and play a major role in age-related diseases and cancer. A complicated and entangled network of DNA damage response (DDR) mechanisms, including multiple DNA repair pathways, damage tolerance processes, and cell-cycle checkpoints safeguard genomic integrity.
Giglia-Mari, G. +2 more
openaire +4 more sources
Engineering a DNA damage response without DNA damage [PDF]
Genome Biology, 2008 Recent work has achieved the feat of activating the DNA damage checkpoint in the absence of DNA damage, revealing the importance of protein-chromatin associations for the activation, amplification and maintenance of the DNA damage response.
Yeung, ManTek, Durocher, Daniel
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Experimental and Molecular Medicine, 2022 Antitumor therapeutic strategies that fundamentally rely on the induction of DNA damage to eradicate and inhibit the growth of cancer cells are integral approaches to cancer therapy.
Yasser Abuetabh +6 more
semanticscholar +1 more source
DNA Damage Tolerance Pathways in Human Cells: A Potential Therapeutic Target
Frontiers in Oncology, 2022 DNA lesions arising from both exogenous and endogenous sources occur frequently in DNA. During DNA replication, the presence of unrepaired DNA damage in the template can arrest replication fork progression, leading to fork collapse, double-strand break ...
Ashlynn Ai Li Ler +2 more
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Chromatin compartmentalization regulates the response to DNA damage
Nature, 2023 The DNA damage response is essential to safeguard genome integrity. Although the contribution of chromatin in DNA repair has been investigated^ 1 , 2 , the contribution of chromosome folding to these processes remains unclear^ 3 .
C. Arnould +17 more
semanticscholar +1 more source
Ribonucleotide triggered DNA damage and RNA-DNA damage responses [PDF]
RNA Biology, 2014 Research indicates that the transient contamination of DNA with ribonucleotides exceeds all other known types of DNA damage combined. The consequences of ribose incorporation into DNA, and the identity of protein factors operating in this RNA-DNA realm to protect genomic integrity from RNA-triggered events are emerging. Left unrepaired, the presence of
Bret D, Wallace, R Scott, Williams
openaire +2 more sources