Results 31 to 40 of about 1,846,477 (392)
Cell Reports, 2014 The R2TP cochaperone complex plays a critical role in the assembly of multisubunit machines, including small nucleolar ribonucleoproteins (snoRNPs), RNA polymerase II, and the mTORC1 and SMG1 kinase complexes, but the molecular basis of substrate ...
Zuzana Hořejší +9 more
doaj +1 more source
Medulloblastoma and the DNA Damage Response
Frontiers in Oncology, 2022 Medulloblastoma (MB) is the most common malignant brain tumor in children with standard of care consisting of surgery, radiation, and chemotherapy. Recent molecular profiling led to the identification of four molecularly distinct MB subgroups – Wingless (
Leon F. McSwain +9 more
doaj +1 more source
The DNA damage response acts as a safeguardagainst harmful DNA–RNA hybrids ofdifferent origins [PDF]
, 2019 Despite playing physiological roles in specific situations, DNA–RNA hybrids threat genome integrity. To investigate how cells do counteract spontaneous DNA–RNA hybrids, here we screen an siRNA library covering 240 human DNA damage response (DDR) genes ...
Aguilera López, Andrés +5 more
core +1 more source
Quantitative mechanisms of DNA damage sensing and signaling
, 2020 DNA damage occurs abundantly during normal cellular proliferation. This necessitates that cellular DNA damage response and checkpoint pathways monitor the cellular DNA damage load and that DNA damage signaling is quantitative.
Bantele, S., Pfander, B.
core +1 more source
Requirement of the FATC domain of protein kinase Tel1 for localization to DNA ends and target protein recognition [PDF]
, 2015 Two large phosphatidylinositol 3-kinase-related protein kinases (PIKKs), ATM and ATR, play a central role in the DNA damage response pathway. PIKKs contain a highly conserved extreme C-terminus called the FRAP-ATM-TRRAP-C-terminal (FATC) domain.
Ghosh, A. +5 more
core +1 more source
AsSIRTing the DNA damage response [PDF]
Trends in Cell Biology, 2008 In mammalian cells, changes in signaling networks and expressed proteins ensure the adequate detection and management of damaged macromolecules. Here, we review an emergent pathway of maintenance of homeostasis following genotoxic stress. The RNA-binding protein HuR associates with sirtuin (SIRT)1 mRNA and maintains constitutively elevated levels of ...
Myriam, Gorospe, Rafael, de Cabo
openaire +2 more sources
DNA-PKcs: A Multi-Faceted Player in DNA Damage Response
Frontiers in Genetics, 2020 DNA-dependent protein kinase catalytic subunit (DNA-PKcs) is a member of the phosphatidylinositol 3-kinase related kinase family, which can phosphorylate more than 700 substrates.
Xiaoqiao Yue +4 more
semanticscholar +1 more source
Transcriptional responses to DNA damage [PDF]
DNA Repair, 2019 In response to the threat of DNA damage, cells exhibit a dramatic and multi-factorial response spanning from transcriptional changes to protein modifications, collectively known as the DNA damage response (DDR). Here, we review the literature surrounding the transcriptional response to DNA damage.
Erica, Silva, Trey, Ideker
openaire +2 more sources
Autophagic Organelles in DNA Damage Response
Frontiers in Cell and Developmental Biology, 2021 Autophagy is an important subcellular event engaged in the maintenance of cellular homeostasis via the degradation of cargo proteins and malfunctioning organelles.
Jeongha Kim +7 more
doaj +1 more source
DNA damage and repair proteins in cellular response to sulfur mustard in Iranian veterans more than two decades after exposure [PDF]
, 2018 Delayed effects of sulfur mustard (SM) exposure on the levels of five important damage/repair proteins were investigated in 40 SM-exposed veterans of Iran-Iraq war and 35 unexposed controls.
Balali-Mood, Mahdi +7 more
core +2 more sources