Results 41 to 50 of about 1,846,477 (392)
Neurology, 2018 An estimated 105 DNA lesions occur daily in the mammalian genome as a consequence of spontaneous decay, replication errors, and cell metabolism, including reactive oxygen species produced by the mitochondria. Oxidative stress is a major mechanism of DNA damage in the nervous system.
E. Coon, E. Benarroch
semanticscholar +3 more sources
Tyrosine dephosphorylation of H2AX modulates apoptosis and survival decisions. [PDF]
, 2009 Life and death fate decisions allow cells to avoid massive apoptotic death in response to genotoxic stress. Although the regulatory mechanisms and signalling pathways controlling DNA repair and apoptosis are well characterized, the precise molecular ...
Cook, Peter J +5 more
core +2 more sources
CRISPR–Cas9 genome editing induces a p53-mediated DNA damage response
Nature Medicine, 2018 Here, we report that genome editing by CRISPR–Cas9 induces a p53-mediated DNA damage response and cell cycle arrest in immortalized human retinal pigment epithelial cells, leading to a selection against cells with a functional p53 pathway.
E. Haapaniemi +4 more
semanticscholar +1 more source
Bacterial Genotoxin-Induced DNA Damage and Modulation of the Host Immune Microenvironment
Toxins, 2020 Bacterial genotoxins (BTGX) induce DNA damage, which results in senescence or apoptosis of the target cells if not properly repaired. Three BTGXs have been identified: the cytolethal distending toxin (CDT) family produced by several Gram-negative ...
Océane C.B. Martin, Teresa Frisan
doaj +1 more source
P53 aggregation, interactions with tau, and impaired DNA damage response in Alzheimer’s disease
Acta Neuropathologica Communications, 2020 The transcription factor, p53, is critical for many important cellular functions involved in genome integrity, including cell cycle control, DNA damage response, and apoptosis.
K. Farmer +5 more
semanticscholar +1 more source
The concerted roles of FANCM and Rad52 in the protection of common fragile sites
Nature Communications, 2018 Fanconi anemia core proteins have been linked to common fragile site stability. Here the authors shed light into the role of FANCM in common fragile site protection by suppressing double-strand break formation and mitotic recombination.
Hailong Wang +5 more
doaj +1 more source
RTEL1 Inhibits Trinucleotide Repeat Expansions and Fragility
Cell Reports, 2014 Human RTEL1 is an essential, multifunctional helicase that maintains telomeres, regulates homologous recombination, and helps prevent bone marrow failure.
Aisling Frizzell +6 more
doaj +1 more source
Arabidopsis RecQl4A suppresses homologous recombination and modulates DNA damage responses [PDF]
, 2005 The DNA damage response and DNA recombination are two interrelated mechanisms involved in maintaining the integrity of the genome, but in plants they are poorly understood.
Bachrati +64 more
core +3 more sources
Long noncoding RNA SNHG12 integrates a DNA-PK–mediated DNA damage response and vascular senescence
Science Translational Medicine, 2020 Deficiency of lncRNA SNHG12 impairs DNA damage repair in the vessel wall and predisposes to vascular senescence and atherosclerosis. A senescent lnc to atherosclerosis DNA damage and senescence are thought to enhance atherosclerotic lesion formation ...
S. Haemmig +22 more
semanticscholar +1 more source
MicroRNAs, damage levels, and DNA damage response control
Trends in Genetics, 2021 DNA damage-inducible miRNAs are likely to be functional in the DNA damage response. This response can elicit damage resolution and cell survival or apoptosis. The current, albeit incomplete, picture suggests that miRNAs can affect cell fate via modulation of key response proteins, but the question is, who's in charge?
Hartwig Visser, Adam D. Thomas
openaire +2 more sources