Results 41 to 50 of about 1,287,961 (310)

O-GlcNAcylation at S659 enhances SARS-CoV-2 spike protein stability and pseudoparticle packaging efficiency

Microbiology Spectrum
The spike (S) protein of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) plays a crucial role in viral entry and pathogenesis, making it an important target for therapeutic strategies.
Ting Xu, Jie Li, Xiaoxuan Lu, Shuai Song, Shengnan Wang, Jing Li, Leiliang Zhang   +6 more
doaj   +1 more source

Anti-cancer immune responses to DNA damage response inhibitors: Molecular mechanisms and progress toward clinical translation

Frontiers in Oncology, 2022
DNA damage response inhibitors are widely used anti-cancer agents that have potent activity against tumor cells with deficiencies in various DNA damage response proteins such as BRCA1/2. Inhibition of other proteins in this pathway including PARP, DNA-PK,
Lindsey Carlsen, Lindsey Carlsen, Lindsey Carlsen, Lindsey Carlsen, Lindsey Carlsen, Wafik S. El-Deiry, Wafik S. El-Deiry, Wafik S. El-Deiry, Wafik S. El-Deiry, Wafik S. El-Deiry, Wafik S. El-Deiry   +10 more
doaj   +1 more source

Moving From Poly (ADP-Ribose) Polymerase Inhibition to Targeting DNA Repair and DNA Damage Response in Cancer Therapy.

Journal of Clinical Oncology, 2019
The DNA damage response (DDR) pathway coordinates the identification, signaling, and repair of DNA damage caused by endogenous or exogenous factors and regulates cell-cycle progression with DNA repair to minimize DNA damage being permanently passed ...
C. Gourley, J. Balmaña, J. Ledermann, V. Serra, R. Dent, S. Loibl, E. Pujade-Lauraine, S. Boulton   +7 more
semanticscholar   +1 more source

The nicotinamide hypothesis revisited—plant defense signaling integrating PARP, nicotinamide, nicotinic acid, epigenetics, and glutathione

FEBS Letters, EarlyView.
Nicotinamide (NIC) and nicotinic acid (NIA) are proposed as stress signaling compounds in plants. Oxidative stress may lead to single strand breaks (SSB) in DNA, which activate poly(ADP‐ribose) polymerase (PARP). NIC and NIA are then formed from NAD. NIC and NIA can promote epigenetic changes leading to the expression of defense genes specific for the ...
Torkel Berglund, Anna B. Ohlsson
wiley   +1 more source

DNA damage response inhibition at dysfunctional telomeres by modulation of telomeric DNA damage response RNAs

Nature Communications, 2017
The DNA damage response (DDR) involves site-specific small non-coding RNAs. Here the authors show that telomere dysfunction induces transcription of telomeric DNA damage response RNAs that are necessary for DDR activation, which can be specifically muted
Francesca Rossiello, Julio Aguado, Sara Sepe, Fabio Iannelli, Quan Nguyen, Sethuramasundaram Pitchiaya, Piero Carninci, Fabrizio d’Adda di Fagagna   +7 more
doaj   +1 more source

Single cis‐elements in brassinosteroid‐induced upregulated genes are insufficient to recruit both redox states of the BIL1/BZR1 DNA‐binding domain

FEBS Letters, EarlyView.
Phytohormone brassinosteroid‐induced gene regulation by the transcription factor BIL1/BZR1 involves redox‐dependent DNA‐binding alternation and interaction with the transcription factor PIF4. The reduced BIL1/BZR1 dimer binds preferred cis‐elements, while oxidation alters its oligomerization state and disrupts DNA‐binding ability.
Shohei Nosaki, Masae Ohtsuka, Takeshi Nakano, Masaru Tanokura, Takuya Miyakawa   +4 more
wiley   +1 more source

O-GlcNAcylation of YTHDF2 antagonizes ERK-dependent phosphorylation and inhibits lung carcinoma

Fundamental Research
The intracellular O-linked N-acetylglucosamine (O-GlcNAc) glycosylation mediates many signal transduction events and regulates tumorigenesis. Previously the RNA N6-methyladenosine (m6A) reader, YTH (YT521-B homology) domain 2 (YTHDF2), has been shown to ...
Jie Li, Wen Zhou, Jianzhi Zhang, Li Ma, Zhuan Lv, Yiqun Geng, Xing Chen, Jing Li   +7 more
doaj   +1 more source

A working model for cytoplasmic assembly of H/ACA snoRNPs

FEBS Letters, EarlyView.
Dyskerin is the component of nuclear H/ACA ribonucleoproteins (RNPs) endowed with pseudouridine synthase catalytic activity. Two isoforms of human dyskerin have been characterized: the abundant Iso1, mainly nuclear, and the shorter Iso3, mainly cytoplasmic but occasionally imported into nuclei.
Alberto Angrisani, Maria Furia
wiley   +1 more source

Curcumin-Mediated HDAC Inhibition Suppresses the DNA Damage Response and Contributes to Increased DNA Damage Sensitivity. [PDF]

PLoS ONE, 2015
Chemo- and radiotherapy cause multiple forms of DNA damage and lead to the death of cancer cells. Inhibitors of the DNA damage response are candidate drugs for use in combination therapies to increase the efficacy of such treatments.
Shu-Huei Wang, Pei-Ya Lin, Ya-Chen Chiu, Ju-Sui Huang, Yi-Tsen Kuo, Jen-Chine Wu, Chin-Chuan Chen   +6 more
doaj   +1 more source

Roles of DNA damage in renal tubular epithelial cells injury

Frontiers in Physiology, 2023
The prevalence of renal diseases including acute kidney injury (AKI) and chronic kidney disease (CKD) is increasing worldwide. However, the pathogenesis of most renal diseases is still unclear and effective treatments are still lacking.
Peipei Wang, Peipei Wang, Peipei Wang, Jing Ouyang, Jing Ouyang, Jing Ouyang, Zhanjun Jia, Zhanjun Jia, Zhanjun Jia, Aihua Zhang, Aihua Zhang, Aihua Zhang, Yunwen Yang, Yunwen Yang, Yunwen Yang   +14 more
doaj   +1 more source