Results 71 to 80 of about 1,204,389 (301)

A metabolic map of the DNA damage response identifies PRDX1 in the control of nuclear ROS scavenging and aspartate availability

Molecular Systems Biology, 2023
While cellular metabolism impacts the DNA damage response, a systematic understanding of the metabolic requirements that are crucial for DNA damage repair has yet to be achieved. Here, we investigate the metabolic enzymes and processes that are essential
Amandine Moretton, Savvas Kourtis, Antoni Gañez Zapater, Chiara Calabrò, Maria Lorena Espinar Calvo, Frédéric Fontaine, Evangelia Darai, Etna Abad Cortel, Samuel Block, Laura Pascual‐Reguant, Natalia Pardo‐Lorente, Ritobrata Ghose, Matthew G Vander Heiden, Ana Janic, André C Müller, Joanna I Loizou, Sara Sdelci   +16 more
doaj   +1 more source

Roles of DNA damage in renal tubular epithelial cells injury

Frontiers in Physiology, 2023
The prevalence of renal diseases including acute kidney injury (AKI) and chronic kidney disease (CKD) is increasing worldwide. However, the pathogenesis of most renal diseases is still unclear and effective treatments are still lacking.
Peipei Wang, Peipei Wang, Peipei Wang, Jing Ouyang, Jing Ouyang, Jing Ouyang, Zhanjun Jia, Zhanjun Jia, Zhanjun Jia, Aihua Zhang, Aihua Zhang, Aihua Zhang, Yunwen Yang, Yunwen Yang, Yunwen Yang   +14 more
doaj   +1 more source

Cell Death Response to DNA Damage. [PDF]

, 2019
The cell death response to DNA damage is discussed in this Perspectives piece with cancer as the backdrop because DNA damaging agents (DDA) are widely used to treat cancer.
Wang, Jean YJ
core   +1 more source

Co-transcriptional R-loops are the main cause of estrogen-induced DNA damage. [PDF]

, 2016
The hormone estrogen (E2) binds the estrogen receptor to promote transcription of E2-responsive genes in the breast and other tissues. E2 also has links to genomic instability, and elevated E2 levels are tied to breast cancer.
Bocek, Michael, Chédin, Frédéric, Cimprich, Karlene A, Crossley, Madzia P, Sanz, Lionel A, Sollier, Julie, Stork, Caroline Townsend, Swigut, Tomek   +7 more
core   +3 more sources

Inhibiting stearoyl‐CoA desaturase suppresses bone metastatic prostate cancer by modulating cellular stress, mTOR signaling, and DNA damage response

FEBS Letters, EarlyView.
Bone metastasis in prostate cancer (PCa) patients is a clinical hurdle due to the poor understanding of the supportive bone microenvironment. Here, we identify stearoyl‐CoA desaturase (SCD) as a tumor‐promoting enzyme and potential therapeutic target in bone metastatic PCa.
Alexis Wilson, Mackenzie K Herroon, Shane Mecca, Laimar C Garmo, Jacob Lindquist, Shrila Rajendran, Steve M. Patrick, Izabela Podgorski   +7 more
wiley   +1 more source

Curcumin-Mediated HDAC Inhibition Suppresses the DNA Damage Response and Contributes to Increased DNA Damage Sensitivity. [PDF]

PLoS ONE, 2015
Chemo- and radiotherapy cause multiple forms of DNA damage and lead to the death of cancer cells. Inhibitors of the DNA damage response are candidate drugs for use in combination therapies to increase the efficacy of such treatments.
Shu-Huei Wang, Pei-Ya Lin, Ya-Chen Chiu, Ju-Sui Huang, Yi-Tsen Kuo, Jen-Chine Wu, Chin-Chuan Chen   +6 more
doaj   +1 more source

Structural biology of ferritin nanocages

FEBS Letters, EarlyView.
Ferritin is a conserved iron‐storage protein that sequesters iron as a ferric mineral core within a nanocage, protecting cells from oxidative damage and maintaining iron homeostasis. This review discusses ferritin biology, structure, and function, and highlights recent cryo‐EM studies revealing mechanisms of ferritinophagy, cellular iron uptake, and ...
Eloise Mastrangelo, Flavio Di Pisa
wiley   +1 more source

Wild-type p53-induced phosphatase 1 down-regulation promotes apoptosis by activating the DNA damage-response pathway in amyotrophic lateral sclerosis

Neurobiology of Disease, 2020
Accumulation of DNA damage has been detected in the spinal cord of patients as well as in the G93A mouse model of amyotrophic lateral sclerosis (ALS).
Yue-Qing Yang, Yong-Hui Zheng, Chun-Ting Zhang, Wei-Wei Liang, Shu-Yu Wang, Xu-Dong Wang, Ying Wang, Tian-Hang Wang, Hong-Quan Jiang, Hong-Lin Feng   +9 more
doaj   +1 more source

DNA damage response and hematological malignancy [PDF]

International Journal of Hematology, 2017
DNA damage is a serious threat to cellular homeostasis. Damaged DNA leads to genomic instability, mutation, senescence, and/or cell death. DNA damage triggers a cellular response called the DNA damage response (DDR), followed by activation of the DNA repair machinery. DDR both maintains cellular homeostasis and prevents cancer development.
openaire   +3 more sources

Contribution of DNA repair and cell cycle checkpoint arrest to the maintenance of genomic stability [PDF]

, 2006
DNA damage response mechanisms encompass pathways of DNA repair, cell cycle checkpoint arrest and apoptosis. Together, these mechanisms function to maintain genomic stability in the face of exogenous and endogenous DNA damage.
Ahnesorg, Buck, Calsou, Chappell, Chun, Cui, Difilippantonio, Dore, Fernandez-Capetillo, Frank, Gao, Gladdy, Hefferin, Hirao, Jeggo, Jeggo, Kemp, Kuhne, Kurz, Lavin, Lee, Liu, Lobrich, Lukas, Ma, Markus Löbrich, Moshous, Moshous, Nick McElhinny, Penny A. Jeggo, Poinsignon, Riballo, Rooney, Rothkamm, Stankovic, Stankovic, Terzoudi, Walker, Wang, Weterings, Wyman, Zhang   +41 more
core   +1 more source