Results 71 to 80 of about 1,846,477 (392)

O-GlcNAcylation at S659 enhances SARS-CoV-2 spike protein stability and pseudoparticle packaging efficiency

Microbiology Spectrum
The spike (S) protein of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) plays a crucial role in viral entry and pathogenesis, making it an important target for therapeutic strategies.
Ting Xu, Jie Li, Xiaoxuan Lu, Shuai Song, Shengnan Wang, Jing Li, Leiliang Zhang   +6 more
doaj   +1 more source

Anti-cancer immune responses to DNA damage response inhibitors: Molecular mechanisms and progress toward clinical translation

Frontiers in Oncology, 2022
DNA damage response inhibitors are widely used anti-cancer agents that have potent activity against tumor cells with deficiencies in various DNA damage response proteins such as BRCA1/2. Inhibition of other proteins in this pathway including PARP, DNA-PK,
Lindsey Carlsen, Lindsey Carlsen, Lindsey Carlsen, Lindsey Carlsen, Lindsey Carlsen, Wafik S. El-Deiry, Wafik S. El-Deiry, Wafik S. El-Deiry, Wafik S. El-Deiry, Wafik S. El-Deiry, Wafik S. El-Deiry   +10 more
doaj   +1 more source

Modulation of gene expression in endothelial cells in response to high LET nickel ion irradiation [PDF]

, 2014
Ionizing radiation can elicit harmful effects on the cardiovascular system at high doses. Endothelial cells are critical targets in radiation-induced cardiovascular damage.
Aerts, An, Baatout, Sarah, Beck, Michaël, De Vos, Winnok, Dieriks, Birger, Ernst, Eric, Janssen, Ann, Lambert, Charles, Lee, Ryonfa, Michaux, Arlette, Moreels, Marjan, Neefs, Mieke, Quintens, Roel, Rombouts, Charlotte, Tabury, Kevin, Van Oostveldt, Patric   +15 more
core   +1 more source

Hematopoietic (stem) cells—The elixir of life?

FEBS Letters, EarlyView.
The aging of HSCs (hematopoietic stem cells) and the blood system leads to the decline of other organs. Rejuvenating aged HSCs improves the function of the blood system, slowing the aging of the heart, kidney, brain, and liver, and the occurrence of age‐related diseases.
Emilie L. Cerezo, Jonah Anderson, Emilie Dinh Vedrenne, Noël Yeh Martín, Jette Lengefeld   +4 more
wiley   +1 more source

DNA damage response inhibition at dysfunctional telomeres by modulation of telomeric DNA damage response RNAs

Nature Communications, 2017
The DNA damage response (DDR) involves site-specific small non-coding RNAs. Here the authors show that telomere dysfunction induces transcription of telomeric DNA damage response RNAs that are necessary for DDR activation, which can be specifically muted
Francesca Rossiello, Julio Aguado, Sara Sepe, Fabio Iannelli, Quan Nguyen, Sethuramasundaram Pitchiaya, Piero Carninci, Fabrizio d’Adda di Fagagna   +7 more
doaj   +1 more source

Mice lacking NF-κB1 exhibit marked DNA damage responses and more severe gastric pathology in response to intraperitoneal tamoxifen administration [PDF]

, 2017
Tamoxifen (TAM) has recently been shown to cause acute gastric atrophy and metaplasia in mice. We have previously demonstrated that the outcome of Helicobacter felis infection, which induces similar gastric lesions in mice, is altered by deletion of ...
A Iannetti, A Rehemtulla, AB Rogers, B Bang, C Van Themsche, CA Duckworth, CY Wang, DH Phillips, DY Graham, F Liu, J Burclaff, JB Saenz, JG Fox, JM Williams, K Ijiri, M Sigal, M Yu, MD Burkitt, MD Burkitt, MD Burkitt, N Novac, P Correa, R Hu, R Poltz, SMC Przemeck, WJ Huh, X Wang, Y Wang, YJ Merga   +28 more
core   +1 more source

The Caenorhabditis elegans DPF‐3 and human DPP4 have tripeptidyl peptidase activity

FEBS Letters, EarlyView.
The dipeptidyl peptidase IV (DPPIV) family comprises serine proteases classically defined by their ability to remove dipeptides from the N‐termini of substrates, a feature that gave the family its name. Here, we report the discovery of a previously unrecognized tripeptidyl peptidase activity in DPPIV family members from two different species.
Aditya Trivedi, Rajani Kanth Gudipati
wiley   +1 more source

O-GlcNAcylation of YTHDF2 antagonizes ERK-dependent phosphorylation and inhibits lung carcinoma

Fundamental Research
The intracellular O-linked N-acetylglucosamine (O-GlcNAc) glycosylation mediates many signal transduction events and regulates tumorigenesis. Previously the RNA N6-methyladenosine (m6A) reader, YTH (YT521-B homology) domain 2 (YTHDF2), has been shown to ...
Jie Li, Wen Zhou, Jianzhi Zhang, Li Ma, Zhuan Lv, Yiqun Geng, Xing Chen, Jing Li   +7 more
doaj   +1 more source

Curcumin-Mediated HDAC Inhibition Suppresses the DNA Damage Response and Contributes to Increased DNA Damage Sensitivity. [PDF]

PLoS ONE, 2015
Chemo- and radiotherapy cause multiple forms of DNA damage and lead to the death of cancer cells. Inhibitors of the DNA damage response are candidate drugs for use in combination therapies to increase the efficacy of such treatments.
Shu-Huei Wang, Pei-Ya Lin, Ya-Chen Chiu, Ju-Sui Huang, Yi-Tsen Kuo, Jen-Chine Wu, Chin-Chuan Chen   +6 more
doaj   +1 more source

High atomic weight, high-energy radiation (HZE) induces transcriptional responses shared with conventional stresses in addition to a core "DSB" response specific to clastogenic treatments. [PDF]

, 2014
Plants exhibit a robust transcriptional response to gamma radiation which includes the induction of transcripts required for homologous recombination and the suppression of transcripts that promote cell cycle progression.
Britt, Anne B, Conklin, Phillip A, Culligan, Kevin M, Huefner, Neil D, Missirian, Victor   +4 more
core   +2 more sources