Results 71 to 80 of about 1,287,961 (310)

The p53-caspase-2 axis in the cell cycle and DNA damage response [PDF]

, 2021
Yoon Lim, Loretta Dorstyn, Sharad Kumar
openalex   +1 more source

mTORC1 pathway in DNA damage response

Biopolymers and Cell, 2019
Living organisms have evolved various mechanisms to control their metabolism and response to various stresses, allowing them to survive and grow in different environments In eukaryotes, the highly conserved mechanistic target of rapamycin (mTOR ...
Yinxing Ma, L. Silveri, J. LaCava, Y. Vassetzky, S. Dokudovskaya, A. Mouche, Jérôme Archambeau, C. Ricordel, L. Chaillot, -. Nico, las Bigot, T. Guillaudeux, Muriel, Grenon, R. Pedeux   +14 more
semanticscholar   +1 more source

DNA Damage Response

Arteriosclerosis, Thrombosis and Vascular Biology, 2020
Vascular calcification is a ubiquitous pathology of aging. Oxidative stress, persistent DNA damage, and senescence are major pathways driving both cellular and tissue aging, and emerging evidence suggests that these pathways are activated, and even ...
M. Duer, Andrew M. Cobb, C. Shanahan
semanticscholar   +1 more source

The zinc finger domains of PARP‐1 are selectively and potently inhibited by the Au(I)‐based drugs sodium aurothiomalate and aurothioglucose

FEBS Letters, EarlyView.
PARP‐1 is a key enzyme in the DNA damage response, and its inhibition induces cancer cell death via synthetic lethality. Au(I)‐based drugs, such as aurothioglucose and sodium aurothiomalate, block PARP‐1's DNA‐dependent activity by targeting its zinc finger domains.
Uliana Bashtanova, Melinda Jane Duer
wiley   +1 more source

The Interplay Between the DNA Damage Response, RNA Processing and Extracellular Vesicles

Frontiers in Oncology, 2020
RNA processing was recently found to affect DNA damage response. The RNA processing factors THRAP3 and BCLAF1 play critical role in keeping DNA genomic stability by regulating the transcription, mRNA splicing and export of DNA repair proteins BRCA2 ...
Xiangbing Meng, Xiangbing Meng, Shujie Yang, Shujie Yang, Vanessa J. A. Camp   +4 more
doaj   +1 more source

Multidimensional OMICs reveal ARID1A orchestrated control of DNA damage, splicing, and cell cycle in normal‐like and malignant urothelial cells

Molecular Oncology, EarlyView.
Loss of the frequently mutated chromatin remodeler ARID1A, a subunit of the SWI/SNF cBAF complex, results in less open chromatin, alternative splicing, and the failure to stop cells from progressing through the cell cycle after DNA damage in bladder (cancer) cells. Created in BioRender. Epigenetic regulators, such as the SWI/SNF complex, with important
Rebecca M. Schlösser, Florian Krumbach, Eyleen Corrales, Geoffroy Andrieux, Christian Preisinger, Franziska Liss, Alexandra Golzmann, Melanie Boerries, Kerstin Becker, Ruth Knüchel, Stefan Garczyk, Bernhard Lüscher   +11 more
wiley   +1 more source

CHROMATIN STRUCTURE AND DNA DAMAGE RESPONSE

Паёми Сино, 2017
Genomic integrity is constantly exposed to the products of metabolic activities and environmental processes that can induce DNA damage. A well-organized network of signaling cascade, designated as DNA damage response (DDR), encompasses systems of damage ...
M.A. NORMATOVA
doaj   +1 more source

Virus DNA Replication and the Host DNA Damage Response.

Annual Review of Virology, 2018
Viral DNA genomes have limited coding capacity and therefore harness cellular factors to facilitate replication of their genomes and generate progeny virions.
M. Weitzman, Amélie Fradet-Turcotte
semanticscholar   +1 more source

Multi‐omic characterization of consensus molecular subtype 1 (CMS1) colorectal cancer with dampened immune response improves precision medicine

Molecular Oncology, EarlyView.
This study highlights the importance of multi‐omic analyses in characterizing colorectal cancers. Indeed, our analysis revealed a rare CMS1 exhibiting dampened immune activation, including reduced PD‐1 expression, moderate CD8+ T‐cell infiltration, and suppressed JAK/STAT pathway.
Livia Concetti, Manuel Scimeca, Julia Bischof, Jonathan Woodsmith, Massimiliano Agostini, Cristina Fiorani, Yufang Shi, Eleonora Candi, Gerry Melino, Alessandro Mauriello, Giuseppe S. Sica   +10 more
wiley   +1 more source

Damage-induced lncRNAs control the DNA damage response through interaction with DDRNAs at individual double-strand breaks

Nature Cell Biology, 2017
The DNA damage response (DDR) preserves genomic integrity. Small non-coding RNAs termed DDRNAs are generated at DNA double-strand breaks (DSBs) and are critical for DDR activation.
F. Michelini, S. Pitchiaya, V. Vitelli, Sheetal Sharma, Ubaldo Gioia, Fabio Pessina, Matteo Cabrini, Yejun Wang, Ilaria Capozzo, F. Iannelli, Valentina Matti, S. Francia, G. Shivashankar, N. Walter, F. d’Adda di Fagagna   +14 more
semanticscholar   +1 more source