Methylation-sensitive expression of a DNA demethylase gene serves as an epigenetic rheostat. [PDF]
PLoS Genetics, 2015 Genomes must balance active suppression of transposable elements (TEs) with the need to maintain gene expression. In Arabidopsis, euchromatic TEs are targeted by RNA-directed DNA methylation (RdDM).
Ben P Williams +3 more
doaj +7 more sources
Molecular mechanisms and biological functions of active DNA demethylation in plants [PDF]
Epigenetics & ChromatinDNA methylation is a conserved epigenetic modification that plays important roles in silencing transposable elements, regulating gene expression, and maintaining genome stability.
Ruixian Zhu, Yan Xue, Weiqiang Qian
doaj +2 more sources
Allele-specific DNA demethylation editing leads to stable upregulation of allele-specific gene expression [PDF]
iScienceSummary: Epigenome editing is an emerging technology that allows to rewrite epigenome states and reprogram gene expression. Here, we have developed allele-specific DNA demethylation editing at gene promoters containing an SNP by sgRNA/dCas9 mediated ...
Nivethika Rajaram +3 more
doaj +2 more sources
Induction of DNA Demethylation: Strategies and Consequences [PDF]
EpigenomesDNA methylation is an important epigenetic modification with a plethora of effects on cells, ranging from the regulation of gene transcription to shaping chromatin structure.
Pietro Salvatore Carollo, Viviana Barra
doaj +2 more sources
Poly(ADP-ribosyl)ation acts in the DNA demethylation of mouse primordial germ cells also with DNA damage-independent roles. [PDF]
PLoS ONE, 2012 Poly(ADP-ribosyl)ation regulates chromatin structure and transcription driving epigenetic events. In particular, Parp1 is able to directly influence DNA methylation patterns controlling transcription and activity of Dnmt1.
Fabio Ciccarone +7 more
doaj +9 more sources
TNC upregulation promotes glioma tumourigenesis through TDG-mediated active DNA demethylation [PDF]
Cell Death DiscoveryGliomas represent the most predominant primary malignant tumor in central nervous system. Thymine DNA glycosylase (TDG) is a central component in active DNA demethylation.
Hongyu Xu +10 more
doaj +2 more sources
Temporally discordant chromatin accessibility and DNA demethylation define short- and long-term enhancer regulation during cell fate specification [PDF]
Cell ReportsSummary: Chromatin and DNA modifications mediate the transcriptional activity of lineage-specifying enhancers, but recent work challenges the dogma that joint chromatin accessibility and DNA demethylation are prerequisites for transcription.
Lindsey N. Guerin +10 more
doaj +2 more sources
Active DNA demethylation upstream of rod-photoreceptor fate determination is required for retinal development. [PDF]
PLoS BiologyRetinal cell fate specification from multipotent retinal progenitors is governed by dynamic changes in chromatin structure and gene expression. Methylation at cytosines in DNA (5mC) is actively regulated for proper control of gene expression and ...
Ismael Hernández-Núñez +10 more
doaj +2 more sources
Targeted DNA Demethylation: Vectors, Effectors and Perspectives [PDF]
Biomedicines, 2023 Aberrant DNA hypermethylation at regulatory cis-elements of particular genes is seen in a plethora of pathological conditions including cardiovascular, neurological, immunological, gastrointestinal and renal diseases, as well as in cancer, diabetes and ...
Naohiro Yano, Alexey V. Fedulov
doaj +2 more sources
Hypoxia-induced genome-wide DNA demethylation by DNMT3A and EMT of cancer cells [PDF]
Cellular & Molecular Biology LettersBackground Despite the comprehensive advancement in the field of cancer therapeutics, there remains an urgent need to identify new pathophysiological mechanisms that can be targeted in isolation or in combination with existing therapeutic regimens.
Biswanath Chatterjee +10 more
doaj +2 more sources