Results 191 to 200 of about 96,036 (271)

Dual DNA demethylation mechanisms implement epigenetic memory driven by the pioneer factor PAX7. [PDF]

Sci Adv
Harris J, Mayran A, Gouhier A, Gauthier Y, Sleiman NH, Merabet S, Dukatz M, Bashtrykov P, Jeltsch A, Djambazian H, Chen SH, Balsalobre A, Drouin J.   +12 more
europepmc   +1 more source

Mitophagy and Ubiquitination Coordinate Context‐Specific Mitochondrial Quality Control and EMT/MET Plasticity to Drive Cancer Cell Invasion

Advanced Science, Volume 13, Issue 16, 18 March 2026.
Metastatic invasion emerges when tumor‐intrinsic programs and microenvironmental forces converge on mitochondrial quality control. A context‐stratified framework links mtROS, mtDNA integrity, mechanics and nutrient/oxygen cues to fission–fusion remodeling, mtUPR and mitophagy.
Bin‐Hsu Mao, Bo‐Kai Su, Ying‐Jan Wang, Ting‐Yuan Tu   +3 more
wiley   +1 more source

CCNY-mediated phosphorylation and TET2-BACH1-driven DNA demethylation activate PRC1 to augment NSCLC progression. [PDF]

J Exp Clin Cancer Res
Huang D, Chu X, Wu C, Wang X, Shi M, Chen X, Lyu Y, Li D, Gu X.   +8 more
europepmc   +1 more source

DNA Demethylation In Vitro [PDF]

Cell, 1998
openaire   +1 more source

Gut Microbiota‐Non‐Coding RNA Axis in Immune Modulation and Disease: From Mechanisms to Clinical Translation

Advanced Science, Volume 13, Issue 16, 18 March 2026.
ABSTRACT Immune homeostasis is indispensable for preserving organismal integrity, orchestrated through complex molecular networks encompassing immune cell dynamics, microbial cues, and epigenetic regulation. Among these, the gut microbiota‐non‐coding RNA (ncRNA) axis has recently garnered substantial attention as a multifaceted modulator of host ...
Bonan Chen, Guoming Chen, Xieyuan Leng, Qianfan Li, Wenhao Wu, Wenqiu Wu, Zixuan Liu, Zilan Zhong, Xiaohong Zheng, Wei Kang, Fazheng Ren, Yigan Zhang, Juan Chen   +12 more
wiley   +1 more source

PROSER1 modulates DNA demethylation through dual mechanisms to prevent syndromic developmental malformations. [PDF]

Genes Dev
Fleming A, Knatko EV, Li X, Zoch A, Heckhausen Z, Stransky S, Brenes AJ, Sidoli S, Hajkova P, O'Carroll D, Rasmussen KD.   +10 more
europepmc   +2 more sources

5-Hydroxymethylcytosine: Far Beyond the Intermediate of DNA Demethylation. [PDF]

Int J Mol Sci
Zheng K, Lyu Z, Chen J, Chen G.
europepmc   +1 more source

The role of vitamin D receptor signaling in hair follicle health and alopecia: Current understanding and therapeutic implications

Journal of Cell Communication and Signaling, Volume 20, Issue 1, March 2026.
The vitamin D receptor (VDR) regulates hair follicle biology through ligand‐dependent and ligand‐independent mechanisms by heterodimerizing with retinoid X receptor, recruiting coactivator complexes, and activating target genes including Wnt inhibitors, hair keratins, and cell cycle regulators.
Liancheng Guan, Fan Yang, Meijuan Li, Yujia Chen, Zexin Zhao, Hongxia Li, Deping Luo, Qian Li, Yunzhi Chen   +8 more
wiley   +1 more source

Anticancer effects of zinc ion-mediated DNA demethylation in oesophageal squamous cell carcinoma. [PDF]

Front Pharmacol
Zhou B, Wang C, Huang Y, Yang X, Ye T, Shen L, Lv Q, Mao W, Zhao A.   +8 more
europepmc   +1 more source

ALKBH3 suppresses ischemia/reperfusion‐induced PANoptosis by regulating the ZBED6/STAT1/AIM2 axis through m1A demethylation

Clinical and Translational Medicine, Volume 16, Issue 3, March 2026.
ALKBH3 alleviates myocardial ischemia/reperfusion injury by suppressing PANoptosis. ALKBH3 promotes ZBED6 translation via mRNA m1A demethylation. ZBED6 promotes the interaction between STAT1 and NEDD4L to facilitate STAT1 ubiquitination and subsequent degradation.
Hongtao Diao, Chunlei Wang, Yuting Xiong, Qiaoyue Zhao, Xinyue Zhang, Xiaohui Qi, Yuan Zou, Jiaxuan Li, Linghua Zeng, Wei Si, Feng Zhang, Ping Pang, Ning Wang, Yu Bian, Baofeng Yang   +14 more
wiley   +1 more source