Results 41 to 50 of about 96,036 (271)

DNA methylation dynamics in aging: How far are we from understanding the mechanisms? [PDF]

, 2018
DNA methylation is currently the most promising molecular marker for monitoring aging and predicting life expectancy. However, the mechanisms underlying age-related DNA methylation changes remain mostly undiscovered.Here we discuss the current knowledge ...
Caiafa, Paola, Ciccarone, Fabio, Tagliatesta, Stefano, Zampieri, Michele   +3 more
core   +1 more source

DNA methylation and DNA methyltransferases [PDF]

, 2017
The prevailing views as to the form, function, and regulation of genomic methylation patterns have their origin many years in the past, at a time when the structure of the mammalian genome was only dimly perceived, when the number of protein-encoding ...
Bestor, Timothy H, Boulard, Mathieu, Edwards, John R, Yarychkivska, Olya   +3 more
core   +3 more sources

DEMETER plant DNA demethylase induces antiviral response by interferon signalling in animal cells

Scientific Reports, 2017
DNA methylation is a prominent epigenetic modification in plants and animals regulated by similar mechanisms but the process of DNA demethylation is profoundly different.
Young Geun Mok, Ki Young Choi, Seung Hwan Hong, Jin Hoe Huh   +3 more
doaj   +1 more source

NEIL1 and NEIL2 DNA glycosylases protect neural crest development against mitochondrial oxidative stress

eLife, 2019
Base excision repair (BER) functions not only in the maintenance of genomic integrity but also in active DNA demethylation and epigenetic gene regulation.
Dandan Han, Lars Schomacher, Katrin M Schüle, Medhavi Mallick, Michael U Musheev, Emil Karaulanov, Laura Krebs, Annika von Seggern, Christof Niehrs   +8 more
doaj   +1 more source

Age-associated alterations in DNA methylation and expression of methyltransferase and demethylase genes in Arabidopsis thaliana

Biologia Plantarum, 2016
Little is known about the contributions of DNA methylation/demethylation to plant aging and senescence. We used Arabidopsis thaliana to study how increasing age of an annual plant species influences DNA methylation.
Z. V. Ogneva, A. S. Dubrovina, K. V. Kiselev   +2 more
doaj   +1 more source

Eicosapentaenoic acid induces DNA demethylation in carcinoma cells through a TET1-dependent mechanism [PDF]

, 2018
In cancer cells, global genomic hypomethylation is found together with localized hypermethylation of CpG islands within the promoters and regulatory regions of silenced tumor suppressor genes.
Billi, Monia, Cannarile, Lorenza, Ceccarelli, Veronica, Grignani, Francesco, Ottini, Laura, Riccardi, Carlo, Ronchetti, Simona, Talesa, Vincenzo Nicola, Valentini, Virginia, Vecchini, Alba   +9 more
core   +1 more source

Epigenetic Regulation of Genomic Stability by Vitamin C

Frontiers in Genetics, 2021
DNA methylation plays an important role in the maintenance of genomic stability. Ten-eleven translocation proteins (TETs) are a family of iron (Fe2+) and α-KG -dependent dioxygenases that regulate DNA methylation levels by oxidizing 5-methylcystosine ...
John P. Brabson, John P. Brabson, Tiffany Leesang, Tiffany Leesang, Sofia Mohammad, Luisa Cimmino, Luisa Cimmino   +6 more
doaj   +1 more source

Decitabine impact on the endocytosis regulator RhoA, the folate carriers RFC1 and FOLR1, and the glucose transporter GLUT4 in human tumors. [PDF]

, 2014
BackgroundIn 31 solid tumor patients treated with the demethylating agent decitabine, we performed tumor biopsies before and after the first cycle of decitabine and used immunohistochemistry (IHC) to assess whether decitabine increased expression of ...
A Kumari, AS Yang, C Festuccia, C Zeller, CA Stidley, CJ Piyathilake, D Ma, D Matei, D Shang, DJ Stewart, DJ Stewart, DJ Stewart, DJ Stewart, DJ Stewart, DJ Stewart, DW Shen, E Gordian, E San Jose-Eneriz, EA Braga, F Crea, F Fang, H Iwata, H Kantarjian, H Kroeger, HM Kantarjian, J Charlet, J Shia, JA Plumb, JP Issa, JP Issa, JS Kim, K Ghoshal, K Onda, K Ramachandran, K Tikoo, KY Tse, L Ding, L Rothem, MA Kane, ML Orta, NH Nabilsi, R Zhao, RH Finnell, S Fu, S Vijayaraghavalu, SB Baylin, SS Muerkoster, T Tanaka, TB Lee, VF Chekhun, X Chang, XJ Liang, Y Li, Y Oki, Y Zhang, ZG Liu   +55 more
core   +2 more sources

Fine mapping and characterization of RLL6 locus required for anti-silencing of a transgene and DNA demethylation in Arabidopsisthaliana

Frontiers in Genetics, 2022
DNA methylation patterns in plants are dynamically shaped by the antagonistic actions of DNA methylation and demethylation pathways. Although the DNA methylation pathway has been well studied, the DNA demethylation pathway, however, are not fully ...
Xiangyu Wang, Min Wang, Jie Dai, Qianqian Wang, Honggui La   +4 more
doaj   +1 more source

DNA Hydroxymethylation at the Interface of the Environment and Nonalcoholic Fatty Liver Disease. [PDF]

, 2019
Non-alcoholic fatty liver disease (NAFLD) is one of the most prevalent forms of chronic liver disorders among adults, children, and adolescents, and a growing epidemic, worldwide.
Besaratinia, Ahmad, Tommasi, Stella
core   +1 more source