Results 51 to 60 of about 96,036 (271)
Domain Model Explains Propagation Dynamics and Stability of Histone H3K27 and H3K36 Methylation Landscapes [PDF]
, 2020 Chromatin states must be maintained during cell proliferation to uphold cellular identity and genome integrity. Inheritance of histone modifications is central in this process. However, the histone modification landscape is challenged by incorporation of
Alabert +58 more
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TET2 inhibits differentiation of embryonic stem cells but does not overcome methylation-induced gene silencing [PDF]
, 2014 TET2 is a methylcytosine dioxygenase that is frequently mutated in myeloid malignancies, notably myelodysplasia and acute myeloid leukemia. TET2 catalyses the conversion of 5′-methylcytosine to 5′-hydroxymethylcytosine within DNA and has been implicated ...
Chevassut, Timothy +2 more
core +3 more sources
Methylation status of Dnmt1 promoter depends on poly(ADP-ribosy)lation [PDF]
, 2007 Research is focused on CpG islands and on the mechanism that poly(ADP-ribosyl)ation uses to defend the unmethylated state of these important DNA sequences which are located in the promoter regions of the housekeeping genes having a role of transcription ...
Zampieri, Michele
core +1 more source
The Emerging Role of Ten-Eleven Translocation 1 in Epigenetic Responses to Environmental Exposures. [PDF]
, 2020 Mounting evidence from epidemiological studies and animal models has linked exposures to environmental factors to changes in epigenetic markers, especially in DNA methylation.
Brown, Anthony P, Ji, Hong, Zhu, Tao
core
DNA Methylation and Demethylation in Arabidopsis [PDF]
The Arabidopsis Book, 2008 Writing about a biological subject based on one species can limit the scope of the discussion, but in the case of DNA methylation and Arabidopsis, the restriction is entirely appropriate. Unlike many other popular model organisms, Arabidopsis has retained and embellished a multi-layered methylation system that contributes to gene and transposon ...
Mary, Gehring, Steven, Henikoff
openaire +2 more sources
BioChem, 2022 Three forms of methylated cytosines are present in the eukaryotic genome: 3-methylcytosine, 4-methylcytosine and 5-methylcytosine. 3-methylcytosines create methyl lesions, which impair local DNA function and flexibility, resulting in replication and ...
Aninda Sundar Dey
doaj +1 more source
TGF-β Drives DNA Demethylation [PDF]
Molecular Cell, 2012 In this issue of Molecular Cell, Thillainadesan et al. (2012) provide evidence that Smad proteins promote locus-specific active DNA demethylation as part of the transforming growth factor β (TGF-β) transcriptional response.
openaire +2 more sources
Genome-wide DNA demethylation in mammals [PDF]
Genome Biology, 2010 The cytidine deaminase AID and elongator-complex proteins contribute to the extensive removal of DNA methylation in mammalian primordial germ cells and in the paternal pronucleus of the zygote.
Sanz, Lionel A +2 more
openaire +2 more sources
Molecular Oncology, EarlyView.Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon +13 more
wiley +1 more source
Epigenetic modification of gene expression in cancer cells by terahertz demethylation
Scientific Reports, 2023 Terahertz (THz) radiation can affect the degree of DNA methylation, the spectral characteristics of which exist in the terahertz region. DNA methylation is an epigenetic modification in which a methyl (CH3) group is attached to cytosine, a nucleobase in ...
Hwayeong Cheon +4 more
doaj +1 more source