Results 81 to 90 of about 373,621 (277)

A new model for ancient DNA decay based on paleogenomic meta-analysis [PDF]

, 2017
The persistence of DNA over archaeological and paleontological timescales in diverse environments has led to a revolutionary body of paleogenomic research, yet the dynamics of DNA degradation are still poorly understood.
Allentoft, Allentoft, Briggs, Campos, Cassidy, Dabney, Deagle, Demarchi, Dodt, Enk, Frantz, Gallego Llorente, Gamba, Gilbert, Grass, Green, Günther, Haak, Haber, Hansen, Hijmans, Hijmans, Hofman, Hofmanová, Jeong, Jónsson, Keller, Kistler, Kistler, Koslicki, Leonardi, Li, Li, Librado, Logan Kistler, Lynch, Martiniano, Matthew Collins, Miller, Olalde, Olalde, Oliver Smith, Orlando, Orlando, Ornstein, Ottoni, Paabo, Palkopoulou, Palmer, Park, Pedersen, Plummer, Poinar, Pääbo, R Development Core Team, Rasmussen, Rasmussen, Robin G. Allaby, Roselyn Ware, Sawyer, Schmitt, Schubert, Shapiro, Skoglund, Skoglund, Smith, Wade, Wales, Wang, Warinner, Weiß, Yoshida, Zhang   +72 more
core   +4 more sources

Reconstructing DNA replication kinetics from small DNA fragments [PDF]

Physical Review E, 2006
In higher organisms, DNA replicates simultaneously from many origins. Recent in vitro experiments have yielded large amounts of data on the state of replication of DNA fragments. From measurements of the time dependence of the average size of replicated and nonreplicated domains, one can estimate the rate of initiation of DNA replication origins, as ...
Haiyang, Zhang, John, Bechhoefer
openaire   +2 more sources

Sequence determinants of RNA G‐quadruplex unfolding by Arg‐rich regions

FEBS Letters, EarlyView.
We show that Arg‐rich peptides selectively unfold RNA G‐quadruplexes, but not RNA stem‐loops or DNA/RNA duplexes. This length‐dependent activity is inhibited by acidic residues and is conserved among SR and SR‐related proteins (SRSF1, SRSF3, SRSF9, U1‐70K, and U2AF1).
Naiduwadura Ivon Upekala De Silva, Puspa Kunwar, Md Ibnul Rifat Rahman, Joanna Koryo Kwao, Nathan Lehman, Zihan Zhang, Trenton Paul, Claire Cheng, Nicholas Truex, Hui‐Ting Lee, Jun Zhang   +10 more
wiley   +1 more source

Correlation of Sperm Parameters With Sperm DNA Damage or Sperm Nucleus Chromatin Status in Oligospermic Individuals Referred to Qom Jihad Daneshgahi Infertility Treatment Center in 2017 (Iran)

Majallah-i Dānishgāh-i ̒Ulūm-i Pizishkī-i Qum, 2021
Background and Objective: Although proper morphology and motility of sperm can be one of the most important factors influencing male fertility, however, these parameters cannot play a decisive role in the health of sperm DNA.
Atefeh Verdi, Mohammad Hossein Nasr-Esfahani, Mohsen Forozanfar, Marziyeh Tavalaee   +3 more
doaj  

Lower sperm DNA fragmentation after r-FSH administration in functional hypogonadotropic hypogonadism [PDF]

, 2013
PURPOSE: An observational clinical and molecular study was designed to evaluate the effects of the administration of recombinant human FSH on sperm DNA fragmentation in men with a non-classical form of hypogonadotropic hypogonadism and idiopathic ...
BOSCO, Liana, Brucculeri, AM, Cittadini, E, Longobardi, S, ROCCHERI, Maria Carmela, Ruvolo, G   +5 more
core   +1 more source

Structural instability impairs function of the UDP‐xylose synthase 1 Ile181Asn variant associated with short‐stature genetic syndrome in humans

FEBS Letters, EarlyView.
The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li, Pedro A. Sánchez‐Murcia, Bernd Nidetzky   +2 more
wiley   +1 more source

Molecular and fossil evidence place the origin of cichlid fishes long after Gondwanan rifting. [PDF]

, 2013
Cichlid fishes are a key model system in the study of adaptive radiation, speciation and evolutionary developmental biology. More than 1600 cichlid species inhabit freshwater and marginal marine environments across several southern landmasses.
Alex Dornburg, Benjamin P. Keck, C. Darrin Hulsey, Christopher H. Martin, Matt Friedman, Matt Friedman, Peter C. Wainwright, Ron I. Eytan, Thomas J. Near, Thomas J. Near   +9 more
core   +1 more source

Evidence based sperm DNA fragmentation [PDF]

Translational Andrology and Urology, 2017
Male factor infertility is an important and current issue in the field of human reproduction. The prevalence of male factor associated infertility is increasing with almost 50% of all cases of fertility treatments being linked to this factor (1). Moreover, the introduction of intracytoplasmic sperm injection (ICSI) in 1992 (2) offered, for patients ...
openaire   +2 more sources

β‐TrCP overexpression enhances cisplatin sensitivity by depleting BRCA1

Molecular Oncology, EarlyView.
Low levels of β‐TrCP (Panel A) allow the accumulation of BRCA1 and CtIP, which facilitate the repair of cisplatin‐induced DNA damage via homologous recombination (HR) and promote tumor cell survival. In contrast, high β‐TrCP expression (Panel B) leads to BRCA1 and CtIP degradation, impairing HR repair, resulting in persistent DNA damage and apoptosis ...
Rocío Jiménez‐Guerrero, Alejandro Belmonte‐Fernández, Mónica González‐Moreno, Laura Rodríguez‐Cordero, Begoña Pérez‐Valderrama, Joaquín Herrero‐Ruíz, Francisco Romero, Carmen Sáez, Miguel Á. Japón   +8 more
wiley   +1 more source

Role of alpha-tocopherol in counteracting DNA damage induced by Ochratoxin A in primary porcine fibroblasts

Italian Journal of Animal Science, 2010
Ochratoxin A is a mycotoxin responsible for disease states in both humans and animals. OTA mechanisms of action are numerous, including lipid peroxidation. Oxidative damage results in the modification of macromolecules (i.e.
Antonella Baldi, Luciano Pinotti, Luciana Rossi, Filippo Galante, Chiara Pecorini, Raffaella Rebucci, Federica Cheli, Eleonora Fusi   +7 more
doaj   +1 more source