Results 131 to 140 of about 44,346 (216)

Development of a Fully Automated, High‐Throughput Molecular Assay for Detection of Rat Hepatitis E Virus in Routine Diagnostics

Journal of Medical Virology, Volume 98, Issue 2, February 2026.
ABSTRACT Recently, cases of human infection with rat hepatitis E virus (ratHEV, Rocahepevirus ratti) have been reported worldwide. Due to the significant genetic differences between ratHEV and human HEV genotypes 1–4 (Paslahepevirus balayani), current HEV diagnostic assays are unable to detect ratHEV.
Jessica Panajotov, Katja Giersch, Lisa Sophie Pflüger, Dominik Nörz, Moritz Grunwald, Hui Ting Tang, Marco Kaiser, Sven Pischke, Rainer G. Ulrich, Susanne Pfefferle, Julian Schulze zur Wisch, Victor Max Corman, Martin Aepfelbacher, Reimar Johne, Marc Lütgehetmann   +14 more
wiley   +1 more source

Oxidative Stress: Molecular Mechanisms, Diseases, and Therapeutic Targets

MedComm, Volume 7, Issue 2, February 2026.
Oxidative stress occurs when the reactive oxygen species (ROS) production overwhelms the ROS scavenging, which lead to genomic instability, epigenetic regulation, proteostasis imbalance, and lipid peroxidation, subsequently causing the occurrence and development of numerous diseases. ABSTRACT Although the physiological level of reactive oxygen species (
Yi Qin, Chen Qian, Wenhao Li, Qihan Wang, Qifeng Sheng, Zheqing Chen, Wei Zhang, Wenming Li, Gaoran Ge, Zhanjun Yan, Dechun Geng   +10 more
wiley   +1 more source

A Novel Human Cellular System for Studying Normal Aging and for Anti‐Aging Discovery

Aging Cell, Volume 25, Issue 2, February 2026.
This study introduces a human cellular aging model using placental trophoblasts (hTSC‐STBs) that mimics key aging features like senescence and genomic instability. It aligns with human tissue aging and responds to anti‐aging treatments, offering a scalable platform to screen potential therapies and bridge lab findings to clinical applications ...
Zhen Feng, Cheuk Shuen Li, Haifeng Fu, Wenxin Jiang, Weiyu Zhang, Yingzhang Huang, Yunying Huang, Timothy Theodore Ka Ki Tam, Yang Li, Fang Liu, Liming Lu, Yin Lau Lee, William Shu Biu Yeung, Gordon Dougan, Pentao Liu   +14 more
wiley   +1 more source

Pulmonary Vascular Endothelial Cells in Lung Diseases: Mechanisms, Therapeutic Strategies, and Future Directions

Cell Proliferation, Volume 59, Issue 2, February 2026.
The pathogenic mechanisms of pulmonary vascular endothelial cells (VECs) in lung diseases and their multimodal therapeutic strategies. ABSTRACT Pulmonary vascular endothelial cells (VECs) are essential for the normal function of the lung, through maintaining vascular barrier integrity, regulating blood flow, and participating in inflammatory responses ...
Qianyue Liu, Hongshuai Zheng, Jing Liu, Ming Gao, Faquan Lin, Lin Liao   +5 more
wiley   +1 more source

Effect of prolonged voluntary wheel running on oxidative stress and defence mechanisms in cortex and hippocampus of healthy female rats

Experimental Physiology, Volume 111, Issue 2, Page 449-463, 1 February 2026.
Abstract Physical exercise promotes brain health and cognitive function possibly through mechanisms that include strengthened resistance to oxidative stress. However, limited research has explored the cumulative effects of regular voluntary exercise on both oxidative stress and defence mechanisms in hippocampus and cortex, two regions essential for ...
Camilla Myrup Holst, Iria Esperon‐Abril, Frederik Bryske Juhl, Jesper Emil Jakobsgaard, Jonas B. Kristiansen, Kristian Vissing, Tinna Stevnsner   +6 more
wiley   +1 more source

Molecular biology techniques as a tool for detection and characterisation of Mycobacterium avium subsp. paratuberculosis [PDF]

, 2002
Mycobacterium avium subsp. paratuberculosis (M. paratuberculosis) is the causative agent of paratuberculosis, also known as Johne’s disease, a chronic intestinal infection in cattle and other ruminants.
Englund, Stina
core  

Development of deaminase-free T-to-S base editor and C-to-G base editor by engineered human uracil DNA glycosylase

Nature Communications
DNA base editors enable direct editing of adenine (A), cytosine (C), or guanine (G), but there is no base editor for direct thymine (T) editing currently. Here we develop two deaminase-free glycosylase-based base editors for direct T editing (gTBE) and C
Huawei Tong, Haoqiang Wang, Xuchen Wang, Nana Liu, Guoling Li, Danni Wu, Yun Li, Ming Jin, Hengbin Li, Yinghui Wei, Tong Li, Yuan Yuan, Linyu Shi, Xuan Yao, Yingsi Zhou, Hui Yang   +15 more
doaj   +1 more source

DNA Repair in Mammalian Cells: Mismatched repair: variations on a theme [PDF]

, 2018
.: Complementary base pairing underlies the genetic template function of the DNA double helix. Therefore, to assure faithful DNA transactions, cells must adhere to a strict application of the Watson-Crick base pairing principle.Yet, mispairing does arise
Kunz, C., Saito, Y., Schär, P.
core  

The kinetics of uracil-N-glycosylase distribution inside replication foci

Scientific Reports
Mismatched nucleobase uracil is commonly repaired through the base excision repair initiated by DNA uracil glycosylases. The data presented in this study strongly indicate that the nuclear uracil-N-glycosylase activity and nuclear protein content in ...
Anna Ligasová, Ivo Frydrych, Barbora Piskláková, David Friedecký, Karel Koberna   +4 more
doaj   +1 more source

Efficient glycosylase-mediated base editing with minimal off-target effects in mammalian embryos

Genome Biology
Developing glycosylase-based base editors (gBEs) to broaden the editing scope is highly desirable for biomedical research and agricultural applications. However, the off-target effects and applicability of gBEs need further investigation.
Yinghui Wei, Xi Cao, Shuhong Huang, Yang Yue, Muhua Luo, Zujiang Liu, Bo Liu, Qijing Zhang, Yangsheng Wu, Liqin Wang, Jiapeng Lin, Yulin Chen, Wenxin Zheng, Weiwei Wu, Kun Xu, Xiaolong Wang   +15 more
doaj   +1 more source