Results 121 to 130 of about 43,780 (231)

Fatal Aortic Rupture at Term Pregnancy Caused by Vascular Ehlers–Danlos Syndrome Diagnosed by Postmortem Genetic Testing Using Formalin‐Fixed, Paraffin‐Embedded Tissue

Journal of Obstetrics and Gynaecology Research, Volume 52, Issue 5, May 2026.
ABSTRACT Vascular Ehlers–Danlos syndrome (vEDS) is a life‐threatening connective tissue disorder that often remains undiagnosed before pregnancy and carries a markedly high risk of maternal mortality. We report the case of a 34‐year‐old pregnant woman who experienced sudden abdominal pain at 39 weeks of gestation and died shortly after delivery ...
Mari Tadakawa, Tomomi Yamaguchi, Hasumi Tomita, Noriyoshi Mochii, Hirotaka Hamada, Mari Tsubata, Tomoki Kosho, Yoko Aoki, Masatoshi Saito   +8 more
wiley   +1 more source

Targeted DNA demethylation in human cells by fusion of a plant 5-methylcytosine DNA glycosylase to a sequence-specific DNA binding domain

Epigenetics, 2017
DNA methylation is a crucial epigenetic mark associated to gene silencing, and its targeted removal is a major goal of epigenetic editing. In animal cells, DNA demethylation involves iterative 5mC oxidation by TET enzymes followed by replication ...
Jara Teresa Parrilla-Doblas, Rafael R. Ariza, Teresa Roldán-Arjona   +2 more
doaj   +1 more source

8-oxoG DNA Glycosylase-1 Inhibition Sensitizes Neuro-2a Cells to Oxidative DNA Base Damage Induced by 900 MHz Radiofrequency Electromagnetic Radiation

Cellular Physiology and Biochemistry, 2015
Background/Aims: The purpose of this study was to explore the in vitro putative genotoxicity during exposure of Neuro-2a cells to radiofrequency electromagnetic fields (RF-EMFs) with or without silencing of 8-oxoG DNA glycosylase-1 (OGG1). Methods: Neuro-
Xiaoya Wang, Chuan Liu, Qinglong Ma, Wei Feng, Lingling Yang, Yonghui Lu, Zhou Zhou, Zhengping Yu, Wei Li, Lei Zhang   +9 more
doaj   +1 more source

Significance of tagl and mfd genes in the virulence of non-typeable Haemophilus infl uenzae [PDF]

, 2015
Non-typeable Haemophilus infl uenzae (NTHi) is an opportunist pathogen well adapted to the human upper respiratory tract and responsible for many respiratory diseases.
David Moranta, Denis A. Spricig, Jordi Barbé, José Antonio Bengoechea, Montserrat Llagostera, Pilar Cortés   +5 more
core   +1 more source

The PagDMG6341–PagWD40–PagPOLD4 Module Coordinates Base Excision Repair in ‘84K’ Poplar (Populus alba × P. glandulosa)

Plant Biotechnology Journal, Volume 24, Issue 5, Page 2956-2969, May 2026.
ABSTRACT Base excision repair (BER) is a critical pathway for repairing damaged DNA bases in cells; however, the mechanisms of protein recruitment and interaction in this pathway remain largely unexplored in higher plants. In this study, we used ‘84K’ poplar (Populus alba × P.
Aoyu Ling, Yijia Jin, Yufei Xia, Shenxiu Jiang, Jianghai Shu, Xiaotong Hu, Kang Du, Pingdong Zhang, Xiangyang Kang   +8 more
wiley   +1 more source

Mechanisms of DNA Damage Recognition by UDG and PARP1 in the Nucleosome

Biomolecules
The DNA base-excision repair (BER) pathway shares the second part of its enzymatic chain with the single-strand break (SSB) repair pathway. BER is initiated by a glycosylase, such as UDG, while SSBR is initiated by the multifunctional enzyme PARP1.
Safwen Ghediri, Parvathy A. P. Sarma, Vinnarasi Saravanan, Corinne Abbadie, Ralf Blossey, Fabrizio Cleri   +5 more
doaj   +1 more source

Pa-AGOG, the founding member of a new family of archaeal 8-oxoguanine DNA-glycosylases [PDF]

, 2017
Oxidative damage represents a major threat to genomic stability, as the major product of DNA oxidation, 8-oxoguanine (GO), frequently mispairs with adenine during replication.
Hunziker, P., Jiricny, J., Lingaraju, G M., Sartori, A A., Winkler, F K.   +4 more
core  

Cellular Levels of 8-Oxoguanine in either DNA or the Nucleotide Pool Play Pivotal Roles in Carcinogenesis and Survival of Cancer Cells [PDF]

8-Oxoguanine, a major oxidized base lesion formed by reactive oxygen species, causes G to T transversion mutations or leads to cell death in mammals if it accumulates in DNA.
Nakabeppu, Yusaku, 中別府, 雄作
core   +1 more source

Illuminating DNA repair in action: structural insights into a photocaged glycosylase complex

IUCrJ
Structural analysis of the co-crystal between human DNA glycosylase hOGG1 and a light-sensitive substrate analog highlights its utility as a platform for real-time observation of catalytic dynamics.
Michihiro Suga
doaj   +1 more source

Spectral Analysis of Protein-Protein Interactions in Drosophila melanogaster

, 2004
Within a case study on the protein-protein interaction network (PIN) of Drosophila melanogaster we investigate the relation between the network's spectral properties and its structural features such as the prevalence of specific subgraphs or duplicate ...
B. Bollobás, B. Bollobás, Christel Kamp, D. Cvetković, D. Cvetković, F. Chung, F. Chung, G. Amoutzias, Kim Christensen, M. Mihail, N. Biggs, S. Ohno   +11 more
core   +1 more source