Results 111 to 120 of about 1,564,144 (179)

Purification and characterization of human 3-methyladenine-DNA glycosylase

, 1993
A human cDNA coding sequence for a 3-methyladenine-DNA glycosylase was expressed in Escherichia coli. In addition to the full-length 3-methyladenine-DNA glycosylase coding sequence, two other sequences (resulting from differential RNA splicing and the ...
Connor, Timothy R O’, Timothy R.O’ Connor   +1 more
core   +1 more source

The ‘very moment’ when UDG recognizes a flipped-out uracil base in dsDNA

Scientific Reports
Uracil-DNA glycosylase (UDG) is the first enzyme in the base-excision repair (BER) pathway, acting on uracil bases in DNA. How UDG finds its targets has not been conclusively resolved yet.
Vinnarasi Saravanan, Nessim Raouraoua, Guillaume Brysbaert, Stefano Giordano, Marc F. Lensink, Fabrizio Cleri, Ralf Blossey   +6 more
doaj   +1 more source

Illuminating DNA repair in action: structural insights into a photocaged glycosylase complex

IUCrJ
Structural analysis of the co-crystal between human DNA glycosylase hOGG1 and a light-sensitive substrate analog highlights its utility as a platform for real-time observation of catalytic dynamics.
Michihiro Suga
doaj   +1 more source

Crystal structure of the Lactococcus lactis formamidopyrimidine-DNA glycosylase bound to an abasic site analogue-containing DNA

, 2002
International audienceThe formamidopyrimidine-DNA glycosylase (Fpg, MutM) is a bifunctional base excision repair enzyme (DNA glycosylase/AP lyase) that removes a wide range of oxidized purines, such as 8-oxoguanine and imidazole ring-opened purines, from
Castaing, Bertrand, Pereira de Jésus, Karine, Zelwer, Charles, Serre, Laurence, Boiteux, Serge   +4 more
core   +1 more source

8oxoG:A Is Structurally Accommodated in the Nucleosome Core Particle, Yet Inaccessible to MUTYH-Initiated DNA Repair

Biomolecules
Eukaryotic genomic DNA is packaged into chromatin as nucleosomes, where it remains susceptible to reactive oxygen species (ROS) that generate the mutagenic lesion 8-oxo-7,8-dihydroguanine (8oxoG).
Abigayle F. Vito, Justin A. Ling, Julia C. Ferrara, Caleb S. Jacques, Natacha Gillet, Roy González-Alemán, Yuya Qiu, Mohammad Hashemian, Carlos H. Trasviña-Arenas, Sheila S. David, Sarah Delaney, Emmanuelle Bignon, Bret D. Freudenthal   +12 more
doaj   +1 more source

Analysis of an Anomalous Mutant of MutM DNA Glycosylase Leads to New Insights into the Catalytic Mechanism

, 2016
Analysis of an Anomalous Mutant of MutM DNA Glycosylase Leads to New Insights into the Catalytic ...
Martin Karplus (28062), Gregory L. Verdine (11056), Kwangho Nam (1318347)   +2 more
core   +1 more source

The role of uracil-dna glycosylase and folate in the repair of dna [PDF]

, 2012
Role of Uracil DNA-Glycosylase and Folate In the Repair of Oxidative Damage By Sarah Dubaisi May2012 Advisor: Dr. Diane Cabelof Major: Nutrition and Food Science Degree: Masters of Science The impact of DNA damage on genomic integrity has been widely ...
Dubaisi, Sarah Talal
core  

Development of deaminase-free T-to-S base editor and C-to-G base editor by engineered human uracil DNA glycosylase

Nature Communications
DNA base editors enable direct editing of adenine (A), cytosine (C), or guanine (G), but there is no base editor for direct thymine (T) editing currently. Here we develop two deaminase-free glycosylase-based base editors for direct T editing (gTBE) and C
Huawei Tong, Haoqiang Wang, Xuchen Wang, Nana Liu, Guoling Li, Danni Wu, Yun Li, Ming Jin, Hengbin Li, Yinghui Wei, Tong Li, Yuan Yuan, Linyu Shi, Xuan Yao, Yingsi Zhou, Hui Yang   +15 more
doaj   +1 more source

Inhibitor of the uracil-dna glycosylase enzyme and uses thereof

, 2009
Titular: consejo superior de Investigaciones Científicas (CSIC)This invention relates to a protein that inhibits the viral uracil DNA glycosylase (UDG) enzyme and the use thereof as a therapeutic agent, in particular, as an antiviral agentPeer ...
Bravo, Alicia, Salas, Margarita, Serrano-Heras, Gemma   +2 more
core  

A novel uracil‐DNA glycosylase family related to the helix–hairpin–helix DNA glycosylase superfamily [PDF]

, 2003
Cytosine bases can be deaminated spontaneously to uracil, causing DNA damage. Uracil-DNA glycosylase (UDG), a ubiquitous uracil-excising enzyme found in bacteria and eukaryotes, is one of the enzymes that repair this kind of DNA damage.
황기철, 오재원, 장양수
core