Results 101 to 110 of about 1,564,144 (179)

1,N2-ethenoguanine, a mutagenic DNA adduct, is a primary substrate of Escherichia coli mismatch-specific uracil-DNA glycosylase and human alkylpurine-DNA-N-glycosylase

, 2002
The promutagenic and genotoxic exocyclic DNA adduct 1,N2-ethenoguanine (1,N2-εG) is a major product formed in DNA exposed to lipid peroxidation-derived aldehydes in vitro.
Saparbaev, Murat, Sophie Langouët, Jacques Laval, Elder, Rhoderick, Peter Guengerich, F., Murat Saparbaev, Elder, Rhoderick H., Cyril V. Privezentzev, Hongliang Cai, Rhoderick H. Elder, Privezentzev, Cyril V., Laval, Jacques, Langouët, Sophie, Cai, Hongliang, F. Peter Guengerich, Privezentzev, Cyril V, Saparbaev, Murat K, Elder, Rhoderick H, Guengerich, F Peter   +18 more
core   +1 more source

Structural and Dynamic Features of the Recognition of 8-oxoguanosine Paired with an 8-oxoG-clamp by Human 8-oxoguanine-DNA Glycosylase

Current Issues in Molecular Biology
8-oxoguanine (oxoG) is formed in DNA by the action of reactive oxygen species. As a highly mutagenic and the most common oxidative DNA lesion, it is an important marker of oxidative stress. Human 8-oxoguanine-DNA glycosylase (OGG1) is responsible for its
Maria V. Lukina, Polina V. Zhdanova, Vladimir V. Koval   +2 more
doaj   +1 more source

Uracil-DNA glycosylase activities in hyperthermophilic micro-organisms

, 1996
Hyperthermophiles exist in conditions which present an increased threat to the informational integrity of their DNA, particularly by hydrolytic damage.
Savva, Renos, Pearl, L.H., Koulis, A., Cowan, D.A.   +3 more
core   +1 more source

Supplemental Figure for "Mitochondrial 8-Oxoguanine DNA Glycosylase Mitigates Alveolar Epithelial Cell PINK1 Deficiency, Mitochondrial DNA damage, Apoptosis and Lung Fibrosis"

, 2020
Supplemental Figure for "Mitochondrial 8-Oxoguanine DNA Glycosylase Mitigates Alveolar Epithelial Cell PINK1 Deficiency, Mitochondrial DNA damage, Apoptosis and Lung Fibrosis"
Anjana Yeldandi (8474597), David W. Kamp (7573508), Cara J. Gottardi (250271), Anna P. Lam (8474623), Moises Selman (3449249), Lyudmila Rachek (8474595), Paul Cheresh (8474553), Raul Piseaux Aillon (8474599), Mark Ciesielski (8474602), Renea P. Jablonski (8474575), Karen Ridge (8474605), Viswanathan Natarajan (307479), Seokjo Kim (8474567), Annie Pardo (29364)   +13 more
core   +1 more source

Activity-Based DNA-Gold Nanoparticle Probe as Colorimetric Biosensor for DNA Methyltransferase/Glycosylase Assay

, 2016
We have developed a novel biosensor platform for colorimetric detection of active DNA methyltransferase/glycosylase based on terminal protection of the DNA-gold nanoparticle (AuNP) probes by mechanistically covalent trapping of target enzymes.
Jian-Hui Jiang (12075), Zhan Wu (1572667), Hao Tang (44155), Li-Juan Tang (1869292), Zhen-Kun Wu (1851058)   +4 more
core   +1 more source

Identification of human herpesvirus 6 uracil-DNA glycosylase

, 1994
Uracil-DNA glycosylase encoded in many species functions as a DNA repair enzyme that removes uracil residues from DNA. To investigate he potential function of uracil-DNA glycosylase ncoded by human herpes-virus 6 (HHV-6), we sequenced a DNA clone (pSTY09)
Yuji Isegawa, Shigeo Sato, Takeshi Yamamoto, Koichi Yamanishi   +3 more
core  

A DNA glycosylase from Pyrobaculum aerophilum with an 8-oxoguanine binding mode and a noncanonical helix-hairpin-helix structure

, 2005
Studies of DNA base excision repair (BER) pathways in the hyperthermophilic crenarchaeon Pyrobaculum aerophilum identified an 8-oxoguanine-DNA glycosylase, Pa-AGOG (archaeal GO glycosylase), with distinct functional characteristics. Here, we describe its
Sartori, Alessandro A; https://orcid.org/, Kostrewa, D, Jiricny, J, Prota, A E, Winkler, F K, Lingaraju, G M, Sartori, Alessandro A. (author), Prota, Andrea E. (author), Winkler, Fritz K. (author), Jiricny, Josef (author), Winkler FK, Lingaraju GM, Kostrewa, Dirk (author), Lingaraju, Gondichatnahalli M. (author), Prota AE, Sartori AA, Kostrewa D, Jiricny J   +17 more
core   +1 more source

Mechanisms of DNA Damage Recognition by UDG and PARP1 in the Nucleosome

Biomolecules
The DNA base-excision repair (BER) pathway shares the second part of its enzymatic chain with the single-strand break (SSB) repair pathway. BER is initiated by a glycosylase, such as UDG, while SSBR is initiated by the multifunctional enzyme PARP1.
Safwen Ghediri, Parvathy A. P. Sarma, Vinnarasi Saravanan, Corinne Abbadie, Ralf Blossey, Fabrizio Cleri   +5 more
doaj   +1 more source

Release of sulfur mustard-modified DNA bases by Escherichia coli 3-methyladenine DNA glycosylase II

, 2008
The toxic effects of sulfur mustard have been attributed to DNA modification with the formation of 7-hydroxyethylthioethyl guanine, 3-hydroxyethylthioethyl adenine and the cross-link, di-(2-guanin-7-yl-ethyl)sulfide.
Matijasevic, Zdenka, Stering, Allen, Niu, Tian-Qi, Austin-Ritchie, Paula, Ludlum, David B.   +4 more
core   +1 more source

Physical association of the 2,6-diamino-4-hydroxy-5N-formamidopyrimidine-DNA glycosylase of Escherichia coli and an activity nicking DNA at apurinic/apyrimidinic sites.

, 1989
The 2,6-diamino-4-hydroxy-5N-formamidopyrimidine (Fapy)-DNA glycosylase of Escherichia coli, which is coded for by the fpg gene, excises purine bases with ring-opened imidazoles.
Laval, J, O'Connor, TR
core   +1 more source