OGG1 Inhibitor TH5487 Alters OGG1 Chromatin Dynamics and Prevents Incisions [PDF]
Biomolecules, 2020 8-oxoguanine DNA glycosylase (OGG1) is the main DNA glycosylase responsible for the excision of 7,8-dihydro-8-oxoguanine (8-oxoG) from duplex DNA to initiate base excision repair.
Bishoy M F Hanna +2 more
exaly +5 more sources
OGG1 in Lung—More than Base Excision Repair
Antioxidants, 2022 As the organ executing gas exchange and directly facing the external environment, the lungs are challenged continuously by various stimuli, causing the disequilibration of redox homeostasis and leading to pulmonary diseases.
Yang Xiang, Yang Xiang, Pan Lang
exaly +5 more sources
NEIL1 and NEIL2 Are Recruited as Potential Backup for OGG1 upon OGG1 Depletion or Inhibition by TH5487 [PDF]
International Journal of Molecular Sciences, 2021 DNA damage caused by reactive oxygen species may result in genetic mutations or cell death. Base excision repair (BER) is the major pathway that repairs DNA oxidative damage in order to maintain genomic integrity. In mammals, eleven DNA glycosylases have been reported to initiate BER, where each recognizes a few related DNA substrate lesions with some ...
Bishoy M F Hanna +2 more
exaly +5 more sources
CDK7 as a Potential Exploratory Biomarker for Distinguishing Acute Myocardial Infarction Subtypes via DDR Pathways: Evidence From a Bangladeshi Cohort. [PDF]
Clin CardiolDifferential expression of DNA damage response genes was evaluated in Bangladeshi AMI patients. CDK7 showed significantly higher expression in NSTEMI compared to STEMI, while ATM, OGG1, and NBN showed no subtype‐specific differences, highlighting potential transcriptional heterogeneity between AMI subtypes.
Ripon RH +6 more
europepmc +2 more sources
OGG1 is a novel prognostic indicator in acute myeloid leukaemia [PDF]
Oncogene, 2009 OGG1 (8-oxoguanine DNA glycosylase) constitutes a key component of the DNA base excision repair pathway, catalysing the removal of 8-oxoguanine nucleotides from DNA, thereby suppressing mutagenesis and cell death. We found that OGG1 expression was significantly downregulated by the RUNX1-ETO fusion protein product of the t(8;21) chromosome ...
Alex Tonks, A K Burnett, Darley R L
exaly +3 more sources
Molecular Duality of OGG1: From Genomic Guardian to Redox-Sensitive Modulator in Diseases [PDF]
AntioxidantsInflammation, malignant tumors, and age-related disorders are all associated with oxidative DNA damage. 8-oxoguanine DNA glycosylase 1 (OGG1), which recognizes and repairs intracellular oxidative damage, was initially thought to play a pivotal role in ...
Ranwei Zhong +4 more
doaj +2 more sources
OGG1 Preserves Endothelial-Dependent Vasodilation and Regulates the Frequency and Spatial Area of Endothelial Calcium Signals [PDF]
BiomoleculesEndothelial calcium dysregulation underlies impairments in endothelial-dependent vasodilation (EDV), contributing to vascular disease progression. Repletion of 8-oxoguanine DNA glycosylase (OGG1), an enzyme involved in base excision repair, has been ...
Takreem Aziz +4 more
doaj +2 more sources
Curcumin Attenuates Aroclor 1254-Induced Oxidative, Genotoxic, and Apoptotic Alterations in HepG2 Cells. [PDF]
J Biochem Mol ToxicolIn HepG2 cells, Aroclor 1254 induced oxidative stress, DNA damage, apoptosis, and mutagenicity; co‐treatment with curcumin restored antioxidant defenses (GSH/thiols; SOD, CAT, GPx, GR, TrxR), reduced ROS and comet/8‐OHdG readouts, and attenuated caspase activation, demonstrating curcumin's hepatoprotective and genoprotective modulation of PCB toxicity.
Erkekoğlu P +3 more
europepmc +2 more sources
Oxidatively damaged DNA in DNA repair-deficient and ethanol-exposed fetal brains induces gene dysregulation and mitochondrial dysfunction associated with neurodevelopmental disorders [PDF]
Redox BiologyOxidatively damaged DNA caused by reactive oxygen species (ROS) in the fetal brain contributes to neurodevelopmental disorders (NDDs), but the mechanism is unclear.
Ashley P. Cheng +6 more
doaj +2 more sources
DNA glycosylases Ogg1 and Mutyh influence gene expression of PRC2 targets associated with cognition [PDF]
Cellular and Molecular Life SciencesBase excision repair, initiated by DNA glycosylases, preserves genomic integrity by removing damaged bases. DNA glycosylases Ogg1 and Mutyh were shown to alter the hippocampal transcriptome independently of DNA damage repair.
Andreas Abentung +7 more
doaj +2 more sources