Results 31 to 40 of about 5,940 (176)

Small molecule-mediated allosteric activation of the base excision repair enzyme 8-oxoguanine DNA glycosylase and its impact on mitochondrial function

Scientific Reports, 2022
8-Oxoguanine DNA glycosylase (OGG1) initiates base excision repair of the oxidative DNA damage product 8-oxoguanine. OGG1 is bifunctional; catalyzing glycosyl bond cleavage, followed by phosphodiester backbone incision via a β-elimination apurinic lyase ...
Gaochao Tian, Steven R. Katchur, Yong Jiang, Jacques Briand, Michael Schaber, Constantine Kreatsoulas, Benjamin Schwartz, Sara Thrall, Alicia M. Davis, Sam Duvall, Brett A. Kaufman, William L. Rumsey   +11 more
doaj   +1 more source

OGG1 competitive inhibitors show important off-target effects by directly inhibiting efflux pumps and disturbing mitotic progression

Frontiers in Cell and Developmental Biology, 2023
One of the most abundant DNA lesions induced by Reactive oxygen species (ROS) is 8-oxoG, a highly mutagenic lesion that compromises genetic instability when not efficiently repaired.
Xhaferr Tanushi, Xhaferr Tanushi, Guillaume Pinna, Guillaume Pinna, Marie Vandamme, Marie Vandamme, Capucine Siberchicot, Capucine Siberchicot, Ostiane D’Augustin, Ostiane D’Augustin, Ostiane D’Augustin, Anne-Marie Di Guilmi, Anne-Marie Di Guilmi, J. Pablo Radicella, J. Pablo Radicella, Bertrand Castaing, Rebecca Smith, Sebastien Huet, Sebastien Huet, François Leteurtre, François Leteurtre, Anna Campalans, Anna Campalans   +22 more
doaj   +1 more source

Induction of OGG1 Gene Expression by HIV-1 Tat [PDF]

Journal of Biological Chemistry, 2005
To identify the cellular gene target for Tat, we performed gene expression profile analysis and found that Tat up-regulates the expression of the OGG1 (8-oxoguanine-DNA glycosylase-1) gene, which encodes an enzyme responsible for repairing the oxidatively damaged guanosine, 8-oxo-7,8-dihydro-2'-deoxyguanosine (8-oxo-dG).
Kenichi, Imai, Kenji, Nakata, Kazuaki, Kawai, Takaichi, Hamano, Nan, Mei, Hiroshi, Kasai, Takashi, Okamoto   +6 more
openaire   +2 more sources

OGG1 co-inhibition antagonizes the tumor-inhibitory effects of targeting MTH1

Redox Biology, 2021
Cancer cells develop protective adaptations against oxidative DNA damage, providing a strong rationale for targeting DNA repair proteins. There has been a high degree of recent interest in inhibiting the mammalian Nudix pyrophosphatase MutT Homolog 1 ...
Ling Zhang, Laura Misiara, Govindi J. Samaranayake, Nisha Sharma, Dao M. Nguyen, Yu-Ki Tahara, Eric T. Kool, Priyamvada Rai   +7 more
doaj   +1 more source

Characterization of oxidative guanine damage and repair in mammalian telomeres. [PDF]

PLoS Genetics, 2010
8-oxo-7,8-dihydroguanine (8-oxoG) and 2,6-diamino-4-hydroxy-5-formamidopyrimidine (FapyG) are among the most common oxidative DNA lesions and are substrates for 8-oxoguanine DNA glycosylase (OGG1)-initiated DNA base excision repair (BER).
Zhilong Wang, David B Rhee, Jian Lu, Christina T Bohr, Fang Zhou, Haritha Vallabhaneni, Nadja C de Souza-Pinto, Yie Liu   +7 more
doaj   +1 more source

Impact of polymorphisms in base excision repair genes on seminal fluid parameters [PDF]

Exploration of Medicine
Aim: Abnormalities in sperm parameters can result from genetic variations in DNA repair genes. The base excision repair (BER) pathway is responsible for maintaining DNA integrity.
Mahmoud A. Hassouna, Mohammed J. Ashour, Hadeer N. Abuwarda, Mazen M. Alzaharna, Fadel A. Sharif   +4 more
doaj   +1 more source

Identification and characterization of OGG1 mutations in patients with Alzheimer's disease [PDF]

Nucleic Acids Research, 2007
Patients with Alzheimer's disease (AD) exhibit higher levels of 8-oxo-guanine (8-oxoG) DNA lesions in their brain, suggesting a reduced or defective 8-oxoG repair. To test this hypothesis, this study investigated 14 AD patients and 10 age-matched controls for mutations of the major 8-oxoG removal gene OGG1.
Mao, Guogen, Pan, Xiaoyu, Zhu, Bei-Bei, Zhang, Yanbin, Yuan, Fenghua, Huang, Jian, Lovell, Mark A., Lee, Maxwell P., Markesbery, William R., Li, Guo-Min, Gu, Liya   +10 more
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Cysteines of OGG1 are important for maintaining cellular homeostasis

The FASEB Journal, 2021
8‐oxoguanine glycosylase (OGG1) is a base excision repair enzyme that recognizes and excises 8‐oxoguanine, a commonly occurring oxidized DNA modification. OGG1 prevents the accumulation of mutations and regulates transcription of genes involved in inflammatory response, cancer growth, and angiogenesis.
Katarina Wang, Marah Maayah, Joann Sweasy, Khadijeh Alnajjar   +3 more
openaire   +1 more source

Substrate-specific binding of 8-oxoguanine DNA glycosylase 1 (OGG1) reprograms mucosal adaptations to chronic airway injury

Frontiers in Immunology, 2023
Recent advances have uncovered the non-random distribution of 7, 8-dihydro-8-oxoguanine (8-oxoGua) induced by reactive oxygen species, which is believed to have epigenetic effects.
Lang Pan, Spiros Vlahopoulos, Lloyd Tanner, Jesper Bergwik, Attila Bacsi, Zsolt Radak, Arne Egesten, Xueqing Ba, Allan R. Brasier, Istvan Boldogh   +9 more
doaj   +1 more source

Association of the OGG1 Ser326Cys polymorphism with tooth loss [PDF]

Journal of Clinical Laboratory Analysis, 2006
AbstractAlthough tooth loss is a serious health problem for elderly people, little is known about the genetic basis for susceptibility to it. In the present study we aimed to find a single nucleotide polymorphism (SNP) associated with tooth loss.
Yoshinori, Hasui, Yuichiro, Hamanaka, Naoko, Okayama, Yutaka, Suehiro, Fumihiko, Shinozaki, Yoshiya, Ueyama, Yuji, Hinoda   +6 more
openaire   +2 more sources