Results 11 to 20 of about 5,940 (176)

The role of cysteines in the structure and function of OGG1 [PDF]

Journal of Biological Chemistry, 2021
8-Oxoguanine glycosylase (OGG1) is a base excision repair enzyme responsible for the recognition and removal of 8-oxoguanine, a commonly occurring oxidized DNA modification. OGG1 prevents the accumulation of mutations and regulates the transcription of various oxidative stress-response genes.
Katarina Wang, Marah Maayah, Joann B. Sweasy, Khadijeh S. Alnajjar   +3 more
openaire   +2 more sources

Association of base excision repair pathway genes OGG1 , XRCC1 and MUTYH polymorphisms and the level of 8-oxo-guanine with increased risk of colorectal cancer occurrence

International Journal of Occupational Medicine and Environmental Health, 2022
Objectives Reduced efficiency of DNA repair systems has long been a suspected factor in increasing the risk of cancer. In this work authors investigate influence of selected polymorphisms of DNA repair genes ( XRCC1 , OGG1 and MUTYH ) and level of ...
Jacek Kabziński, Ireneusz Majsterek
doaj   +1 more source

OGG1 in the Kidney: Beyond Base Excision Repair

Oxidative Medicine and Cellular Longevity, 2022
8‐Oxoguanine DNA glycosylase (OGG1) is a repair protein for 8‐oxoguanine (8‐oxoG) in eukaryotic atopic DNA. Through the initial base excision repair (BER) pathway, 8‐oxoG is recognized and excised, and subsequently, other proteins are recruited to complete the repair. OGG1 is primarily located in the cytoplasm and can enter the nucleus and mitochondria
Fan Zhao, Jiefu Zhu, Lang Shi, Xiongfei Wu   +3 more
openaire   +3 more sources

8-Oxoguanine DNA glycosylase (OGG1) deficiency increases susceptibility to obesity and metabolic dysfunction. [PDF]

PLoS ONE, 2012
Oxidative damage to DNA is mainly repaired via base excision repair, a pathway that is catalyzed by DNA glycosylases such as 8-oxoguanine DNA glycosylase (OGG1). While OGG1 has been implicated in maintaining genomic integrity and preventing tumorigenesis,
Harini Sampath, Vladimir Vartanian, M Rick Rollins, Kunihiko Sakumi, Yusaku Nakabeppu, R Stephen Lloyd   +5 more
doaj   +1 more source

Effect of single mutations in the OGG1 gene found in human tumors on the substrate specificity of the Ogg1 protein [PDF]

Nucleic Acids Research, 2000
We have investigated the effect of single amino acid substitutions of conserved arginines on the catalytic activities of the human Ogg1 protein (alpha-hOgg1-Ser(326)) (wild-type alpha-hOgg1). Mutant forms of hOgg1 with mutations Arg(46)-->Gln (alpha-hOgg1-Gln(46)) and Arg(154)-->His (alpha-hOgg1-His(154)) have previously been identified in human tumors.
M, Audebert, J P, Radicella, M, Dizdaroglu   +2 more
openaire   +2 more sources

Innate Immune Responses to RSV Infection Facilitated by OGG1, an Enzyme Repairing Oxidatively Modified DNA Base Lesions

Journal of Innate Immunity, 2022
The primary cause of morbidity and mortality from infection with respiratory syncytial virus (RSV) is the excessive innate immune response(s) (IIR) in which reactive oxygen species (ROS) play key role(s).
Xu Zheng, Ke Wang, Lang Pan, Wenjing Hao, Yaoyao Xue, Attila Bacsi, Spiros A. Vlahopoulos, Zsolt Radak, Tapas K. Hazra, Allan R. Brasier, Lloyd Tanner, Xueqing Ba, Istvan Boldogh   +12 more
doaj   +1 more source

The E3 Ubiquitin Ligase NEDD4L Targets OGG1 for Ubiquitylation and Modulates the Cellular DNA Damage Response

Frontiers in Cell and Developmental Biology, 2020
8-Oxoguanine DNA glycosylase (OGG1) is the major cellular enzyme required for the excision of 8-oxoguanine DNA base lesions in DNA through the base excision repair (BER) pathway, and therefore plays a major role in suppressing mutagenesis and in ...
Jonathan R. Hughes, Jason L. Parsons, Jason L. Parsons   +2 more
doaj   +1 more source

Oxidative DNA Damage Accelerates Skin Inflammation in Pristane-Induced Lupus Model

Frontiers in Immunology, 2020
Systemic Lupus Erythematosus (SLE) is a chronic inflammatory autoimmune disease in which type I interferons (IFN) play a key role. The IFN response can be triggered when oxidized DNA engages the cytosolic DNA sensing platform cGAS-STING, but the repair ...
Gantsetseg Tumurkhuu, Gantsetseg Tumurkhuu, Gantsetseg Tumurkhuu, Shuang Chen, Shuang Chen, Shuang Chen, Erica N. Montano, Erica N. Montano, Duygu Ercan Laguna, Duygu Ercan Laguna, Gabriela De Los Santos, Gabriela De Los Santos, Jeong Min Yu, Malcolm Lane, Michifumi Yamashita, Janet L. Markman, Luz P. Blanco, Mariana J. Kaplan, Kenichi Shimada, Kenichi Shimada, Kenichi Shimada, Timothy R. Crother, Timothy R. Crother, Timothy R. Crother, Mariko Ishimori, Mariko Ishimori, Daniel J. Wallace, Daniel J. Wallace, Caroline A. Jefferies, Caroline A. Jefferies, Moshe Arditi, Moshe Arditi, Moshe Arditi   +32 more
doaj   +1 more source

OGG1Polymorphisms and Breast Cancer Risk [PDF]

Cancer Epidemiology, Biomarkers & Prevention, 2006
AbstractThe role of oxidative stress in breast cancer risk is still unclear. OGG1 encodes an 8-oxoguanine DNA glycosylase/AP lyase that catalyzes the removal of 8-oxodeoxyguanosine from DNA. 8-Oxodeoxyguanosine, the most abundant lesion generated by oxidative stress, is highly mutagenic.
Pavel, Rossner, Mary Beth, Terry, Marilie D, Gammon, Fang Fang, Zhang, Susan L, Teitelbaum, Sybil M, Eng, Sharon K, Sagiv, Mia M, Gaudet, Alfred I, Neugut, Regina M, Santella   +9 more
openaire   +2 more sources

OGG1 deficiency alters the intestinal microbiome and increases intestinal inflammation in a mouse model.

PLoS ONE, 2020
OGG1-deficient (Ogg1-/-) animals display increased propensity to age-induced and diet-induced metabolic diseases, including insulin resistance and fatty liver.
Holly Simon, Vladimir Vartanian, Melissa H Wong, Yusaku Nakabeppu, Priyanka Sharma, R Stephen Lloyd, Harini Sampath   +6 more
doaj   +1 more source